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Title:
Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes | Nature Medicine
Description:
By implementing the conditions for orthotopic implantation of different types of human breast tumors, the authors have created a publicly available bank of new mouse models that more faithfully recreate individual tumor properties and provide individualized information about tumor behavior and prognosis. Development and preclinical testing of new cancer therapies is limited by the scarcity of in vivo models that authentically reproduce tumor growth and metastatic progression. We report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. These tumor grafts illustrate the diversity of human breast cancer and maintain essential features of the original tumors, including metastasis to specific sites. Co-engraftment of primary human mesenchymal stem cells maintains phenotypic stability of the grafts and increases tumor growth by promoting angiogenesis. We also report that tumor engraftment is a prognostic indicator of disease outcome for women with newly diagnosed breast cancer; orthotopic breast tumor grafting is a step toward individualized models for tumor growth, metastasis and prognosis. This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of breast cancer.
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Keywords {π}
cancer, pubmed, article, breast, google, scholar, cas, nature, tumor, central, metastasis, models, cells, utah, human, stem, access, usa, institute, welm, cell, huntsman, growth, university, supplementary, content, data, research, salt, lake, city, cookies, disease, nat, mouse, gene, res, department, privacy, information, medicine, grafts, pathology, development, preclinical, tumors, open, clin, alw, journal,
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nature portfolio permissions reprints privacy policy advertising cancer research social media nod/scid-related strains author information authors nature 464 nature 456 nature 449 nature 406 nature triple-negative breast cancer node-negative breast cancer anticancer drug development author correspondence nod/scid/Ξ³ springerlink instant access permissions human breast cancer primary xenograft model mesenchymal stem cells regional human breast tumors human breast tumours breast cancer metastasis breast cancer based cancer stem cells breast tumor subtypes efficient tumour formation tumor grafts derived personal data huntsman cancer foundation breast cancer res breast tumor growth huntsman cancer institute privacy mammary stem cells cancer gene discovery development competing financial interests gene expression imposed gene-expression signature gene expression patterns cervical cancer enables data protection medical oncology division explore content subscription content
Questions {β}
- Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
- Models of breast cancer: quo vadis, animal modeling?
- Triple-negative breast cancer: disease entity or title of convenience?
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