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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
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  12. Libraries
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  14. CDN Services

We began analyzing https://www.nature.com/articles/ni1496, but it redirected us to https://www.nature.com/articles/ni1496. The analysis below is for the second page.

Title[redir]:
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells | Nature Immunology
Description:
Interleukin 17 (IL-17)–producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.

Matching Content Categories {📚}

  • Science
  • Education
  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 9,135,289 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, google, scholar, cas, cells, nature, interleukin, immunol, nat, differentiation, human, helper, cell, access, med, content, immunology, factor, dendritic, exp, transforming, growth, producing, production, arthritis, development, cookies, factorβ, autoimmune, mice, receptor, inflammatory, immunity, research, privacy, acostarodriguez, ilproducing, expression, monocytes, activation, inflammation, cytokine, essential, data, information, journal, lanzavecchia, sallusto, distinct, open,

Topics {✒️}

nature portfolio permissions reprints privacy policy granulocyte/macrophage colony-stimulating factor author information authors advertising transforming growth factor-β social media research nature 445 nature 441 nature antonio lanzavecchia & federica sallusto il-17-secreting t-helper phenotype nf-κb signal pathway acute tnbs-induced colitis hu-pbl-scid mice data protection content development personal data springerlink instant access interleukin-1β converting enzyme il-1 receptor antagonist lung cxc chemokine antigen-presenting cell production permissions spontaneous development il-18-stimulated gadd45β required transcription factor rorγt article acosta-rodriguez il-23-mediated il-17 production inflammatory bowel disease ifn-γ production cell-mediated colitis mediate autoimmune encephalomyelitis card9-dependent coupling remote control mechanism privacy competing financial interests tlr activation triggers clinical immunology il-17 receptor signaling joint autoimmune inflammation inflammatory chemokine transport issue learn helmut horten foundation pathogenic effector th17 conventional dendritic cells antigen-presenting cells dendritic langerhans cells

Schema {🗺️}

WebPage:
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         headline:Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
         description:Interleukin 17 (IL-17)–producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
         datePublished:2007-08-05T00:00:00Z
         dateModified:2007-08-05T00:00:00Z
         pageStart:942
         pageEnd:949
         sameAs:https://doi.org/10.1038/ni1496
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            Immunology
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      headline:Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
      description:Interleukin 17 (IL-17)–producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
      datePublished:2007-08-05T00:00:00Z
      dateModified:2007-08-05T00:00:00Z
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         name:Institute for Research in Biomedicine, Bellinzona, Switzerland
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               type:PostalAddress
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               name:Institute for Research in Biomedicine, Bellinzona, Switzerland
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Social Networks {👍}(1)

External Links {🔗}(204)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

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CDN Services {📦}

  • Crossref

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