
NATURE . COM {
}
Title:
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells | Nature Immunology
Description:
Interleukin 17 (IL-17)–producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Social Networks
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$521,200 per month
Estimations show Nature.com's display ad online revenue falls between $347,485 and $955,583 per month.
Keywords {🔍}
article, google, scholar, cas, cells, nature, interleukin, immunol, nat, differentiation, human, helper, cell, access, med, content, immunology, factor, dendritic, exp, transforming, growth, producing, production, arthritis, development, cookies, factorβ, autoimmune, mice, receptor, inflammatory, immunity, research, privacy, acostarodriguez, ilproducing, expression, monocytes, activation, inflammation, cytokine, essential, data, information, journal, lanzavecchia, sallusto, distinct, open,
Topics {✒️}
nature portfolio permissions reprints privacy policy granulocyte/macrophage colony-stimulating factor author information authors advertising transforming growth factor-β social media research nature 445 nature 441 nature antonio lanzavecchia & federica sallusto il-17-secreting t-helper phenotype nf-κb signal pathway acute tnbs-induced colitis hu-pbl-scid mice data protection content development personal data springerlink instant access interleukin-1β converting enzyme il-1 receptor antagonist lung cxc chemokine antigen-presenting cell production permissions spontaneous development il-18-stimulated gadd45β required transcription factor rorγt article acosta-rodriguez il-23-mediated il-17 production inflammatory bowel disease ifn-γ production cell-mediated colitis mediate autoimmune encephalomyelitis card9-dependent coupling remote control mechanism privacy competing financial interests tlr activation triggers clinical immunology il-17 receptor signaling joint autoimmune inflammation inflammatory chemokine transport issue learn helmut horten foundation pathogenic effector th17 conventional dendritic cells antigen-presenting cells dendritic langerhans cells
Schema {🗺️}
WebPage:
mainEntity:
headline:Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17âproducing human T helper cells
description:Interleukin 17 (IL-17)âproducing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
datePublished:2007-08-05T00:00:00Z
dateModified:2007-08-05T00:00:00Z
pageStart:942
pageEnd:949
sameAs:https://doi.org/10.1038/ni1496
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig6_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Eva V Acosta-Rodriguez
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Giorgio Napolitani
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
type:Person
name:Antonio Lanzavecchia
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
type:Person
name:Federica Sallusto
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17âproducing human T helper cells
description:Interleukin 17 (IL-17)âproducing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-β and IL-6 and the transcription factor RORγt. We report here that for human naive CD4+ T cells, RORγt expression and TH-17 polarization were induced by IL-1β and enhanced by IL-6 but were suppressed by transforming growth factor-β and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced TH-17 priming, and this function correlated with antigen-presenting cell production of IL-1β and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human TH-17 cells and emphasize an important difference in the requirements for the differentiation of TH-17 cells in humans and mice.
datePublished:2007-08-05T00:00:00Z
dateModified:2007-08-05T00:00:00Z
pageStart:942
pageEnd:949
sameAs:https://doi.org/10.1038/ni1496
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_Article_BFni1496_Fig6_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Eva V Acosta-Rodriguez
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Giorgio Napolitani
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
type:Person
name:Antonio Lanzavecchia
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
type:Person
name:Federica Sallusto
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Eva V Acosta-Rodriguez
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
name:Giorgio Napolitani
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
name:Antonio Lanzavecchia
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
name:Federica Sallusto
affiliation:
name:Institute for Research in Biomedicine
address:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
name:Institute for Research in Biomedicine, Bellinzona, Switzerland
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(108)
- How much revenue does https://link.springer.com/article/10.1038/ni1496?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle generate?
- Get to know what's the income of https://doi.org/10.1038%2Fni1261
- How much does http://scholar.google.com/scholar_lookup?&title=A%20distinct%20lineage%20of%20CD4%20T%20cells%20regulates%20tissue%20inflammation%20by%20producing%20interleukin%2017&journal=Nat.%20Immunol.&doi=10.1038%2Fni1261&volume=6&pages=1133-1141&publication_year=2005&author=Park%2CH make?
- How much does https://doi.org/10.1038%2Fni1254 pull in monthly?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Interleukin%2017-producing%20CD4%2B%20effector%20T%20cells%20develop%20via%20a%20lineage%20distinct%20from%20the%20T%20helper%20type%201%20and%202%20lineages&journal=Nat.%20Immunol.&doi=10.1038%2Fni1254&volume=6&pages=1123-1132&publication_year=2005&author=Harrington%2CLE?
- Financial intake of https://doi.org/10.1146%2Fannurev.immunol.25.022106.141557
- How much income is http://scholar.google.com/scholar_lookup?&title=IL-17%20family%20cytokines%20and%20the%20expanding%20diversity%20of%20effector%20T%20cell%20lineages&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.25.022106.141557&volume=25&pages=821-852&publication_year=2007&author=Weaver%2CCT&author=Hatton%2CRD&author=Mangan%2CPR&author=Harrington%2CLE earning monthly?
- What's the income of https://doi.org/10.1084%2Fjem.20030896?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Divergent%20pro-%20and%20antiinflammatory%20roles%20for%20IL-23%20and%20IL-12%20in%20joint%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20030896&volume=198&pages=1951-1957&publication_year=2003&author=Murphy%2CCA
- How much revenue does https://doi.org/10.1172%2FJCI21404 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=IL-23%20is%20essential%20for%20T%20cell-mediated%20colitis%20and%20promotes%20inflammation%20via%20IL-17%20and%20IL-6&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI21404&volume=116&pages=1310-1316&publication_year=2006&author=Yen%2CD net monthly?
- https://doi.org/10.1038%2Fnature05505's total income per month
- Revenue of http://scholar.google.com/scholar_lookup?&title=Interleukin-22%2C%20a%20TH17%20cytokine%2C%20mediates%20IL-23-induced%20dermal%20inflammation%20and%20acanthosis&journal=Nature&doi=10.1038%2Fnature05505&volume=445&pages=648-651&publication_year=2007&author=Zheng%2CY
- Discover the revenue of https://doi.org/10.1084%2Fjem.194.4.519
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Requirement%20of%20interleukin%2017%20receptor%20signaling%20for%20lung%20CXC%20chemokine%20and%20granulocyte%20colony-stimulating%20factor%20expression%2C%20neutrophil%20recruitment%2C%20and%20host%20defense&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.4.519&volume=194&pages=519-527&publication_year=2001&author=Ye%2CP
- What's the income of https://doi.org/10.1097%2F01.MIB.0000218764.06959.91?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Critical%20role%20of%20IL-17%20receptor%20signaling%20in%20acute%20TNBS-induced%20colitis&journal=Inflamm.%20Bowel%20Dis.&doi=10.1097%2F01.MIB.0000218764.06959.91&volume=12&pages=382-388&publication_year=2006&author=Zhang%2CZ&author=Zheng%2CM&author=Bindas%2CJ&author=Schwarzenberger%2CP&author=Kolls%2CJK is on a monthly basis
- How much does https://doi.org/10.1002%2F1529-0131%28199905%2942%3A5%3C963%3A%3AAID-ANR15%3E3.0.CO%3B2-E earn?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Human%20interleukin-17%3A%20A%20T%20cell-derived%20proinflammatory%20cytokine%20produced%20by%20the%20rheumatoid%20synovium&journal=Arthritis%20Rheum.&doi=10.1002%2F1529-0131%28199905%2942%3A5%3C963%3A%3AAID-ANR15%3E3.0.CO%3B2-E&volume=42&pages=963-970&publication_year=1999&author=Chabaud%2CM
- https://doi.org/10.1038%2Fnm0502-500 income
- Earnings of http://scholar.google.com/scholar_lookup?&title=Gene-microarray%20analysis%20of%20multiple%20sclerosis%20lesions%20yields%20new%20targets%20validated%20in%20autoimmune%20encephalomyelitis&journal=Nat.%20Med.&doi=10.1038%2Fnm0502-500&volume=8&pages=500-508&publication_year=2002&author=Lock%2CC
- How much revenue does https://doi.org/10.1136%2Fgut.52.1.65 produce monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=Increased%20expression%20of%20interleukin%2017%20in%20inflammatory%20bowel%20disease&journal=Gut&doi=10.1136%2Fgut.52.1.65&volume=52&pages=65-70&publication_year=2003&author=Fujino%2CS make?
- How profitable is https://doi.org/10.1074%2Fjbc.M207577200?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20promotes%20a%20distinct%20CD4%20T%20cell%20activation%20state%20characterized%20by%20the%20production%20of%20interleukin-17&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207577200&volume=278&pages=1910-1914&publication_year=2003&author=Aggarwal%2CS&author=Ghilardi%2CN&author=Xie%2CMH&author=de%20Sauvage%2CFJ&author=Gurney%2CAL?
- What are the earnings of https://doi.org/10.1038%2Fni1391?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Signals%20mediated%20by%20transforming%20growth%20factor-%CE%B2%20initiate%20autoimmune%20encephalomyelitis%2C%20but%20chronic%20inflammation%20is%20needed%20to%20sustain%20disease&journal=Nat.%20Immunol.&doi=10.1038%2Fni1391&volume=7&pages=1151-1156&publication_year=2006&author=Veldhoen%2CM&author=Hocking%2CRJ&author=Flavell%2CRA&author=Stockinger%2CB
- How much revenue does https://doi.org/10.1016%2Fj.immuni.2006.01.001 generate?
- Earnings of http://scholar.google.com/scholar_lookup?&title=TGF%CE%B2%20in%20the%20context%20of%20an%20inflammatory%20cytokine%20milieu%20supports%20de%20novo%20differentiation%20of%20IL-17-producing%20T%20cells&journal=Immunity&doi=10.1016%2Fj.immuni.2006.01.001&volume=24&pages=179-189&publication_year=2006&author=Veldhoen%2CM&author=Hocking%2CRJ&author=Atkins%2CCJ&author=Locksley%2CRM&author=Stockinger%2CB
- How much revenue does https://doi.org/10.1038%2Fnature04754 produce monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Transforming%20growth%20factor-%CE%B2%20induces%20development%20of%20the%20TH17%20lineage&journal=Nature&doi=10.1038%2Fnature04754&volume=441&pages=231-234&publication_year=2006&author=Mangan%2CPR?
- Profit of https://doi.org/10.1038%2Fnature04753
- Income figures for http://scholar.google.com/scholar_lookup?&title=Reciprocal%20developmental%20pathways%20for%20the%20generation%20of%20pathogenic%20effector%20TH17%20and%20regulatory%20T%20cells&journal=Nature&doi=10.1038%2Fnature04753&volume=441&pages=235-238&publication_year=2006&author=Bettelli%2CE
- Learn how profitable https://doi.org/10.4049%2Fjimmunol.176.9.5652 is on a monthly basis
- How much does http://scholar.google.com/scholar_lookup?&title=STAT3%20and%20NF-%CE%BAB%20signal%20pathway%20is%20required%20for%20IL-23-mediated%20IL-17%20production%20in%20spontaneous%20arthritis%20animal%20model%20IL-1%20receptor%20antagonist-deficient%20mice&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.176.9.5652&volume=176&pages=5652-5661&publication_year=2006&author=Cho%2CML generate monthly?
- What's the financial intake of https://doi.org/10.1002%2Feji.200535239?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Divergent%20effects%20of%20IL-12%20and%20IL-23%20on%20the%20production%20of%20IL-17%20by%20human%20T%20cells&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200535239&volume=36&pages=661-670&publication_year=2006&author=Hoeve%2CMA?
- What's the profit of https://doi.org/10.1038%2Fni1375?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Interleukin%2027%20limits%20autoimmune%20encephalomyelitis%20by%20suppressing%20the%20development%20of%20interleukin%2017-producing%20T%20cells&journal=Nat.%20Immunol.&doi=10.1038%2Fni1375&volume=7&pages=929-936&publication_year=2006&author=Batten%2CM have monthly?
- https://doi.org/10.1016%2Fj.immuni.2007.02.009 income
- http://scholar.google.com/scholar_lookup?&title=Interleukin-2%20signaling%20via%20STAT5%20constrains%20T%20helper%2017%20cell%20generation&journal=Immunity&doi=10.1016%2Fj.immuni.2007.02.009&volume=26&pages=371-381&publication_year=2007&author=Laurence%2CA income
- Learn about the earnings of https://doi.org/10.1016%2Fj.cell.2006.07.035
- How much income is http://scholar.google.com/scholar_lookup?&title=The%20orphan%20nuclear%20receptor%20ROR%CE%B3t%20directs%20the%20differentiation%20program%20of%20proinflammatory%20IL-17%2B%20T%20helper%20cells&journal=Cell&doi=10.1016%2Fj.cell.2006.07.035&volume=126&pages=1121-1133&publication_year=2006&author=Ivanov%2CII earning monthly?
- Discover the revenue of https://doi.org/10.1074%2Fjbc.C600321200
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=STAT3%20regulates%20cytokine-mediated%20generation%20of%20inflammatory%20helper%20T%20cells&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.C600321200&volume=282&pages=9358-9363&publication_year=2007&author=Yang%2CXO
- Financial intake of https://doi.org/10.1038%2Fni1467
- How much does http://scholar.google.com/scholar_lookup?&title=Surface%20phenotype%20and%20antigenic%20specificity%20of%20human%20interleukin%2017%E2%80%93producing%20T%20helper%20memory%20cells&journal=Nat.%20Immunol.&doi=10.1038%2Fni1467&volume=8&pages=639-646&publication_year=2007&author=Acosta-Rodriguez%2CEV generate monthly?
- What's https://doi.org/10.1182%2Fblood-2006-04-015016's gross income?
- How much does http://scholar.google.com/scholar_lookup?&title=T-bet%20is%20a%20critical%20determinant%20in%20the%20instability%20of%20the%20IL-17-secreting%20T-helper%20phenotype&journal=Blood&doi=10.1182%2Fblood-2006-04-015016&volume=108&pages=1595-1601&publication_year=2006&author=Mathur%2CAN generate monthly?
- What's the monthly income of https://doi.org/10.1016%2Fj.coi.2003.11.007?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Activation%20of%20dendritic%20cells%3A%20translating%20innate%20into%20adaptive%20immunity&journal=Curr.%20Opin.%20Immunol.&doi=10.1016%2Fj.coi.2003.11.007&volume=16&pages=21-25&publication_year=2004&author=Reis%20e%20Sousa%2CC?
- How much income does https://doi.org/10.1021%2Fbi00179a020 have?
- http://scholar.google.com/scholar_lookup?&title=Inactivation%20of%20interleukin-1%CE%B2%20converting%20enzyme%20by%20peptide%20%28acyloxy%29methyl%20ketones&journal=Biochemistry&doi=10.1021%2Fbi00179a020&volume=33&pages=3934-3940&publication_year=1994&author=Thornberry%2CNA's total income per month
- How much income does https://doi.org/10.1038%2F84264 have?
- How much profit is http://scholar.google.com/scholar_lookup?&title=IL-18-stimulated%20GADD45%CE%B2%20required%20in%20cytokine-induced%2C%20but%20not%20TCR-induced%2C%20IFN-%CE%B3%20production&journal=Nat.%20Immunol.&doi=10.1038%2F84264&volume=2&pages=157-164&publication_year=2001&author=Yang%2CJ&author=Zhu%2CH&author=Murphy%2CTL&author=Ouyang%2CW&author=Murphy%2CKM making per month?
- How much revenue does https://doi.org/10.1073%2Fpnas.1035999100 produce monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=IL-17%20production%20from%20activated%20T%20cells%20is%20required%20for%20the%20spontaneous%20development%20of%20destructive%20arthritis%20in%20mice%20deficient%20in%20IL-1%20receptor%20antagonist&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1035999100&volume=100&pages=5986-5990&publication_year=2003&author=Nakae%2CS?
- What's the monthly money flow for https://doi.org/10.1084%2Fjem.20060285?
- How much does http://scholar.google.com/scholar_lookup?&title=A%20crucial%20role%20for%20interleukin%20%28IL%29-1%20in%20the%20induction%20of%20IL-17-producing%20T%20cells%20that%20mediate%20autoimmune%20encephalomyelitis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20060285&volume=203&pages=1685-1691&publication_year=2006&author=Sutton%2CC&author=Brereton%2CC&author=Keogh%2CB&author=Mills%2CKH&author=Lavelle%2CEC pull in?
- What's the profit of https://doi.org/10.4049%2Fjimmunol.177.11.7980?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=TLR4%20mediates%20vaccine-induced%20protective%20cellular%20immunity%20to%20Bordetella%20pertussis%3A%20role%20of%20IL-17-producing%20T%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.177.11.7980&volume=177&pages=7980-7989&publication_year=2006&author=Higgins%2CSC&author=Jarnicki%2CAG&author=Lavelle%2CEC&author=Mills%2CKH?
- Find out how much https://doi.org/10.1038%2Fni1460 earns monthly
- http://scholar.google.com/scholar_lookup?&title=Syk-%20and%20CARD9-dependent%20coupling%20of%20innate%20immunity%20to%20the%20induction%20of%20T%20helper%20cells%20that%20produce%20interleukin%2017&journal=Nat.%20Immunol.&doi=10.1038%2Fni1460&volume=8&pages=630-638&publication_year=2007&author=Leibundgut-Landmann%2CS's financial summary
- What's the financial gain of https://doi.org/10.1038%2Fnm1246?
- Get to know http://scholar.google.com/scholar_lookup?&title=TLR%20activation%20triggers%20the%20rapid%20differentiation%20of%20monocytes%20into%20macrophages%20and%20dendritic%20cells&journal=Nat.%20Med.&doi=10.1038%2Fnm1246&volume=11&pages=653-660&publication_year=2005&author=Krutzik%2CSR's earnings
- What is the monthly revenue of https://doi.org/10.1016%2FS1074-7613%2800%2980149-1?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Differentiation%20of%20phagocytic%20monocytes%20into%20lymph%20node%20dendritic%20cells%20in%20vivo&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980149-1&volume=11&pages=753-761&publication_year=1999&author=Randolph%2CGJ&author=Inaba%2CK&author=Robbiani%2CDF&author=Steinman%2CRM&author=Muller%2CWA?
- Get to know https://doi.org/10.1038%2Fni1307's earnings
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Langerhans%20cells%20arise%20from%20monocytes%20in%20vivo&journal=Nat.%20Immunol.&doi=10.1038%2Fni1307&volume=7&pages=265-273&publication_year=2006&author=Ginhoux%2CF bring in?
- How much money does https://doi.org/10.1084%2Fjem.194.9.1361 generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Inflammatory%20chemokine%20transport%20and%20presentation%20in%20HEV%3A%20a%20remote%20control%20mechanism%20for%20monocyte%20recruitment%20to%20lymph%20nodes%20in%20inflamed%20tissues&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.9.1361&volume=194&pages=1361-1373&publication_year=2001&author=Palframan%2CRT?
- How much does https://doi.org/10.1084%2Fjem.194.9.1375 rake in every month?
- How much does http://scholar.google.com/scholar_lookup?&title=Tumor%20necrosis%20factor-dependent%20segmental%20control%20of%20MIG%20expression%20by%20high%20endothelial%20venules%20in%20inflamed%20lymph%20nodes%20regulates%20monocyte%20recruitment&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.194.9.1375&volume=194&pages=1375-1384&publication_year=2001&author=Janatpour%2CMJ&author=Hudak%2CS&author=Sathe%2CM&author=Sedgwick%2CJD&author=McEvoy%2CLM generate monthly?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9647250
- Income figures for http://scholar.google.com/scholar_lookup?&title=Enhancing%20effect%20of%20IL-17%20on%20IL-1-induced%20IL-6%20and%20leukemia%20inhibitory%20factor%20production%20by%20rheumatoid%20arthritis%20synoviocytes%20and%20its%20regulation%20by%20Th2%20cytokines&journal=J.%20Immunol.&volume=161&pages=409-414&publication_year=1998&author=Chabaud%2CM&author=Fossiez%2CF&author=Taupin%2CJL&author=Miossec%2CP
- What's the financial outcome of https://doi.org/10.1002%2Fart.21342?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Interleukin-17%20receptor%20deficiency%20results%20in%20impaired%20synovial%20expression%20of%20interleukin-1%20and%20matrix%20metalloproteinases%203%2C%209%2C%20and%2013%20and%20prevents%20cartilage%20destruction%20during%20chronic%20reactivated%20streptococcal%20cell%20wall-induced%20arthritis&journal=Arthritis%20Rheum.&doi=10.1002%2Fart.21342&volume=52&pages=3239-3247&publication_year=2005&author=Koenders%2CMI?
- How much cash flow does https://doi.org/10.1038%2Fncprheum0020 have monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Cytokine%20networks%E2%80%93towards%20new%20therapies%20for%20rheumatoid%20arthritis&journal=Nat.%20Clin.%20Pract.%20Rheumatol.&doi=10.1038%2Fncprheum0020&volume=1&pages=31-39&publication_year=2005&author=McInnes%2CIB&author=Liew%2CFY generate?
- Learn how profitable https://doi.org/10.1016%2Fj.cell.2004.05.004 is on a monthly basis
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Inflammatory%20caspases%3A%20linking%20an%20intracellular%20innate%20immune%20system%20to%20autoinflammatory%20diseases&journal=Cell&doi=10.1016%2Fj.cell.2004.05.004&volume=117&pages=561-574&publication_year=2004&author=Martinon%2CF&author=Tschopp%2CJ have monthly?
- How much profit is https://doi.org/10.1084%2Fjem.179.4.1109 making per month?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Efficient%20presentation%20of%20soluble%20antigen%20by%20cultured%20human%20dendritic%20cells%20is%20maintained%20by%20granulocyte%2Fmacrophage%20colony-stimulating%20factor%20plus%20interleukin%204%20and%20downregulated%20by%20tumor%20necrosis%20factor%20alpha&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.179.4.1109&volume=179&pages=1109-1118&publication_year=1994&author=Sallusto%2CF&author=Lanzavecchia%2CA earns monthly
- Explore the financials of https://doi.org/10.1084%2Fjem.187.6.961
- How much does http://scholar.google.com/scholar_lookup?&title=Transforming%20growth%20factor%20%CE%B21%2C%20in%20the%20presence%20of%20granulocyte%2Fmacrophage%20colony-stimulating%20factor%20and%20interleukin%204%2C%20induces%20differentiation%20of%20human%20peripheral%20blood%20monocytes%20into%20dendritic%20Langerhans%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.187.6.961&volume=187&pages=961-966&publication_year=1998&author=Geissmann%2CF earn?
- How much revenue does https://doi.org/10.1084%2Fjem.191.10.1777 bring in?
- What's http://scholar.google.com/scholar_lookup?&title=Type%20I%20interferon%20as%20a%20powerful%20adjuvant%20for%20monocyte-derived%20dendritic%20cell%20development%20and%20activity%20in%20vitro%20and%20in%20Hu-PBL-SCID%20mice&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.191.10.1777&volume=191&pages=1777-1788&publication_year=2000&author=Santini%2CSM's gross income?
- How much profit is https://citation-needed.springer.com/v2/references/10.1038/ni1496?format=refman&flavour=references making per month?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Eva%20V%20Acosta-Rodriguez pull in monthly?
- Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eva%20V%20Acosta-Rodriguez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Giorgio%20Napolitani
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Giorgio%20Napolitani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Antonio%20Lanzavecchia gross monthly?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Antonio%20Lanzavecchia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
- What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Federica%20Sallusto?
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Federica%20Sallusto%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Find out how much https://static-content.springer.com/esm/art%3A10.1038%2Fni1496/MediaObjects/41590_2007_BFni1496_MOESM24_ESM.pdf earns monthly
- https://s100.copyright.com/AppDispatchServlet?title=Interleukins%201%CE%B2%20and%206%20but%20not%20transforming%20growth%20factor-%CE%B2%20are%20essential%20for%20the%20differentiation%20of%20interleukin%2017%E2%80%93producing%20human%20T%20helper%20cells&author=Eva%20V%20Acosta-Rodriguez%20et%20al&contentID=10.1038%2Fni1496©right=Springer%20Nature%20America%2C%20Inc.&publication=1529-2908&publicationDate=2007-08-05&publisherName=SpringerNature&orderBeanReset=true income
- What's the monthly income of https://citation-needed.springer.com/v2/references/10.1038/ni1496?format=refman&flavour=citation?
- How much does https://doi.org/10.1007/s10875-024-01662-4 net monthly?
- https://doi.org/10.1038/s41467-023-39484-4's total income per month
- What's the financial outcome of https://doi.org/10.1007/s12026-023-09361-9?
- How much money does https://doi.org/10.1038/s41590-022-01386-w generate?
- What's the monthly income of https://doi.org/10.1007/s13206-022-00068-x?
- How much income does https://www.protocols.io/ have?
- How much does https://www.natureindex.com/ pull in?
- How much does http://www.naturechina.com generate monthly?
- How much revenue does https://www.natureasia.com/ja-jp produce monthly?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref