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We are analyzing https://www.nature.com/articles/ni1500.

Title:
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 | Nature Immunology
Description:
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4−/−) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4−/− mice rendered the mice susceptible to experimental autoimmune encephalomyelitis. Irf4−/− T helper cells had less expression of RORγt and more expression of Foxp3, transcription factors important for the differentiation of TH-17 and regulatory T cells, respectively. Altered regulation of both transcription factors contributed to the phenotype of Irf4−/− T helper cells. Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also TH-17 differentiation.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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  • Science
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article, google, scholar, cas, cells, nature, factor, regulatory, helper, differentiation, cell, irf, interferon, interleukin, immunol, access, exp, med, development, transcription, content, lohoff, mice, immunology, autoimmune, foxp, nat, cookies, encephalomyelitis, expression, immunity, privacy, data, inflammatory, type, producing, experimental, regulates, lineage, induction, vivo, institut, information, interferonregulatory, brüstle, christine, mak, factors, receptor, open,

Topics {✒️}

scientific editing nature portfolio permissions reprints privacy policy consensus sequence-binding protein advertising social media transforming growth factor-β author information authors nature 441 nature 448 nature myelin basic protein-specific enhanced tcr-induced apoptosis peripheral cd4+cd25− naive deutsches rheuma-forschungszentrum berlin author correspondence t-helper-cell differentiation regulates immune responses regulating gut microbiota human cd4+cd25+ regulatory data position irf4 th1-type immune responses springerlink instant access content interleukins 1β neurokinin-1 receptor antagonist permissions severely compromised development personal data helper cell development interferon regulatory factor-1 interferon regulatory factor-4 interferon gene induction cd4+cd25+ regulatory data protection tgf-β induction interferon-regulatory factors michael lohoff privacy ets factor pu competing financial interests transcription factor foxp3 experimental autoimmune encephalomyelitis induces autoimmune inflammation issue learn microbial lipopeptides induce tcr transgenic mice charité-universitätsmedizin berlin cell development foxp3 controls regulatory

Schema {🗺️}

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