
NATURE . COM {
}
Title:
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 | Nature Immunology
Description:
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4−/−) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4−/− mice rendered the mice susceptible to experimental autoimmune encephalomyelitis. Irf4−/− T helper cells had less expression of RORγt and more expression of Foxp3, transcription factors important for the differentiation of TH-17 and regulatory T cells, respectively. Altered regulation of both transcription factors contributed to the phenotype of Irf4−/− T helper cells. Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also TH-17 differentiation.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🚀🌠 Tremendous Traffic: 10M - 20M visitors per month
Based on our best estimate, this website will receive around 17,334,432 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$218,500 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $145,651 to $400,541.
Keywords {🔍}
article, google, scholar, cas, cells, nature, factor, regulatory, helper, differentiation, cell, irf, interferon, interleukin, immunol, access, exp, med, development, transcription, content, lohoff, mice, immunology, autoimmune, foxp, nat, cookies, encephalomyelitis, expression, immunity, privacy, data, inflammatory, type, producing, experimental, regulates, lineage, induction, vivo, institut, information, interferonregulatory, brüstle, christine, mak, factors, receptor, open,
Topics {✒️}
scientific editing nature portfolio permissions reprints privacy policy consensus sequence-binding protein advertising social media transforming growth factor-β author information authors nature 441 nature 448 nature myelin basic protein-specific enhanced tcr-induced apoptosis peripheral cd4+cd25− naive deutsches rheuma-forschungszentrum berlin author correspondence t-helper-cell differentiation regulates immune responses regulating gut microbiota human cd4+cd25+ regulatory data position irf4 th1-type immune responses springerlink instant access content interleukins 1β neurokinin-1 receptor antagonist permissions severely compromised development personal data helper cell development interferon regulatory factor-1 interferon regulatory factor-4 interferon gene induction cd4+cd25+ regulatory data protection tgf-β induction interferon-regulatory factors michael lohoff privacy ets factor pu competing financial interests transcription factor foxp3 experimental autoimmune encephalomyelitis induces autoimmune inflammation issue learn microbial lipopeptides induce tcr transgenic mice charité-universitätsmedizin berlin cell development foxp3 controls regulatory
Schema {🗺️}
WebPage:
mainEntity:
headline:The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
description:Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17âproducing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4â/â) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4â/â mice rendered the mice susceptible to experimental autoimmune encephalomyelitis. Irf4â/â T helper cells had less expression of RORγt and more expression of Foxp3, transcription factors important for the differentiation of TH-17 and regulatory T cells, respectively. Altered regulation of both transcription factors contributed to the phenotype of Irf4â/â T helper cells. Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also TH-17 differentiation.
datePublished:2007-08-05T00:00:00Z
dateModified:2007-08-05T00:00:00Z
pageStart:958
pageEnd:966
sameAs:https://doi.org/10.1038/ni1500
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig6_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Anne Brüstle
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sylvia Heink
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
type:Person
name:Magdalena Huber
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Christine Rosenplänter
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Christine Stadelmann
affiliation:
name:Institut für Neuropathologie, Universität Göttingen
address:
name:Institut für Neuropathologie, Universität Göttingen, Göttingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Philipp Yu
affiliation:
name:Institut für Immunologie
address:
name:Institut für Immunologie, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Enrico Arpaia
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Tak W Mak
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Thomas Kamradt
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
type:Person
name:Michael Lohoff
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
description:Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17âproducing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4â/â) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4â/â mice rendered the mice susceptible to experimental autoimmune encephalomyelitis. Irf4â/â T helper cells had less expression of RORγt and more expression of Foxp3, transcription factors important for the differentiation of TH-17 and regulatory T cells, respectively. Altered regulation of both transcription factors contributed to the phenotype of Irf4â/â T helper cells. Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also TH-17 differentiation.
datePublished:2007-08-05T00:00:00Z
dateModified:2007-08-05T00:00:00Z
pageStart:958
pageEnd:966
sameAs:https://doi.org/10.1038/ni1500
keywords:
Biomedicine
general
Immunology
Infectious Diseases
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_Article_BFni1500_Fig6_HTML.jpg
isPartOf:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Anne Brüstle
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sylvia Heink
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
type:Person
name:Magdalena Huber
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Christine Rosenplänter
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Christine Stadelmann
affiliation:
name:Institut für Neuropathologie, Universität Göttingen
address:
name:Institut für Neuropathologie, Universität Göttingen, Göttingen, Germany
type:PostalAddress
type:Organization
type:Person
name:Philipp Yu
affiliation:
name:Institut für Immunologie
address:
name:Institut für Immunologie, Marburg, Germany
type:PostalAddress
type:Organization
type:Person
name:Enrico Arpaia
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Tak W Mak
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Thomas Kamradt
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
type:Person
name:Michael Lohoff
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Immunology
issn:
1529-2916
1529-2908
volumeNumber:8
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
name:Institut für Neuropathologie, Universität Göttingen
address:
name:Institut für Neuropathologie, Universität Göttingen, Göttingen, Germany
type:PostalAddress
name:Institut für Immunologie
address:
name:Institut für Immunologie, Marburg, Germany
type:PostalAddress
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
name:University of Toronto
address:
name:Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Anne Brüstle
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
name:Sylvia Heink
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
name:Magdalena Huber
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
name:Christine Rosenplänter
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
name:Christine Stadelmann
affiliation:
name:Institut für Neuropathologie, Universität Göttingen
address:
name:Institut für Neuropathologie, Universität Göttingen, Göttingen, Germany
type:PostalAddress
type:Organization
name:Philipp Yu
affiliation:
name:Institut für Immunologie
address:
name:Institut für Immunologie, Marburg, Germany
type:PostalAddress
type:Organization
name:Enrico Arpaia
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
name:Tak W Mak
affiliation:
name:Advanced Medical Discovery Institute, University of Toronto
address:
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Canada
type:PostalAddress
type:Organization
name:Thomas Kamradt
affiliation:
name:Institut für Immunologie, Universitätsklinikum Jena
address:
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
type:PostalAddress
type:Organization
name:Michael Lohoff
affiliation:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene
address:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
name:Institut für Neuropathologie, Universität Göttingen, Göttingen, Germany
name:Institut für Immunologie, Marburg, Germany
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
name:Advanced Medical Discovery Institute, University of Toronto, Toronto, Canada
name:Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Canada
name:Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany
name:Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, Germany
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(108)
- Revenue of https://link.springer.com/article/10.1038/ni1500?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- What's the financial gain of https://doi.org/10.1038%2Fni1254?
- How much does http://scholar.google.com/scholar_lookup?&title=Interleukin%2017%E2%80%93producing%20CD4%2B%20effector%20T%20cells%20develop%20via%20a%20lineage%20distinct%20from%20the%20T%20helper%20type%201%20and%202%20lineages&journal=Nat.%20Immunol.&doi=10.1038%2Fni1254&volume=6&pages=1123-1132&publication_year=2005&author=Harrington%2CLE generate monthly?
- https://doi.org/10.4049%2Fjimmunol.165.11.6107's revenue stream
- How much income does http://scholar.google.com/scholar_lookup?&title=Microbial%20lipopeptides%20induce%20the%20production%20of%20IL-17%20in%20TH%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.165.11.6107&volume=165&pages=6107-6115&publication_year=2000&author=Infante-Duarte%2CC&author=Horton%2CHF&author=Byrne%2CMC&author=Kamradt%2CT have?
- Check the income stats for https://doi.org/10.1038%2Fni1261
- Revenue of http://scholar.google.com/scholar_lookup?&title=A%20distinct%20lineage%20of%20CD4%20T%20cells%20regulates%20tissue%20inflammation%20by%20producing%20interleukin%2017&journal=Nat.%20Immunol.&doi=10.1038%2Fni1261&volume=6&pages=1133-1141&publication_year=2005&author=Park%2CH
- How much money does https://doi.org/10.1084%2Fjem.20041257 generate?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=IL-23%20drives%20a%20pathogenic%20T%20cell%20population%20that%20induces%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20041257&volume=201&pages=233-240&publication_year=2005&author=Langrish%2CCL
- How much does https://doi.org/10.1038%2Fnature04753 gross monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Reciprocal%20developmental%20pathways%20for%20the%20generation%20of%20pathogenic%20effector%20TH17%20and%20regulatory%20T%20cells&journal=Nature&doi=10.1038%2Fnature04753&volume=441&pages=235-238&publication_year=2006&author=Bettelli%2CE?
- How much does https://doi.org/10.1038%2Fnature04754 pull in monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Transforming%20growth%20factor-%CE%B2%20induces%20development%20of%20the%20TH17%20lineage&journal=Nature&doi=10.1038%2Fnature04754&volume=441&pages=231-234&publication_year=2006&author=Mangan%2CPR make?
- How much does https://doi.org/10.1016%2Fj.immuni.2006.01.001 rake in every month?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=TGF%CE%B2%20in%20the%20context%20of%20an%20inflammatory%20cytokine%20milieu%20supports%20de%20novo%20differentiation%20of%20IL-17-producing%20T%20cells&journal=Immunity&doi=10.1016%2Fj.immuni.2006.01.001&volume=24&pages=179-189&publication_year=2006&author=Veldhoen%2CM&author=Hocking%2CRJ&author=Atkins%2CCJ&author=Locksley%2CRM&author=Stockinger%2CB?
- How much does https://doi.org/10.1016%2Fj.immuni.2006.06.002 make?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=TH17%3A%20an%20effector%20CD4%20T%20cell%20lineage%20with%20regulatory%20T%20cell%20ties&journal=Immunity&doi=10.1016%2Fj.immuni.2006.06.002&volume=24&pages=677-688&publication_year=2006&author=Weaver%2CCT&author=Harrington%2CLE&author=Mangan%2CPR&author=Gavrieli%2CM&author=Murphy%2CKM?
- Learn how profitable https://doi.org/10.1016%2Fj.cell.2006.07.035 is on a monthly basis
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20orphan%20nuclear%20receptor%20ROR%CE%B3t%20directs%20the%20differentiation%20program%20of%20proinflammatory%20IL-17%2B%20T%20helper%20cells&journal=Cell&doi=10.1016%2Fj.cell.2006.07.035&volume=126&pages=1121-1133&publication_year=2006&author=Ivanov%2CII?
- Explore the financials of https://doi.org/10.1038%2Fnature05970
- How much does http://scholar.google.com/scholar_lookup?&title=IL-21%20initiates%20an%20alternative%20pathway%20to%20induce%20proinflammatory%20TH17%20cells&journal=Nature&doi=10.1038%2Fnature05970&volume=448&pages=484-488&publication_year=2007&author=Korn%2CT pull in monthly?
- Find out how much https://doi.org/10.1016%2Fj.immuni.2006.08.009 earns monthly
- How much income is http://scholar.google.com/scholar_lookup?&title=Type%20I%20interferon%20gene%20induction%20by%20the%20interferon%20regulatory%20factor%20family%20of%20transcription%20factors%206&journal=Immunity&doi=10.1016%2Fj.immuni.2006.08.009&volume=25&pages=349-360&publication_year=2006&author=Honda%2CK&author=Takaoka%2CA&author=Taniguchi%2CT earning monthly?
- What's the financial intake of https://doi.org/10.1038%2Fnri1900?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=IRFs%3A%20master%20regulators%20of%20signalling%20by%20Toll-like%20receptors%20and%20cytosolic%20pattern-recognition%20receptors%207&journal=Nat.%20Rev.%20Immunol.&doi=10.1038%2Fnri1900&volume=6&pages=644-658&publication_year=2006&author=Honda%2CK&author=Taniguchi%2CT?
- Income figures for https://doi.org/10.1038%2Fnri1552
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Roles%20of%20interferon-regulatory%20factors%20in%20T-helper-cell%20differentiation&journal=Nat.%20Rev.%20Immunol.&doi=10.1038%2Fnri1552&volume=5&pages=125-135&publication_year=2005&author=Lohoff%2CM&author=Mak%2CTW?
- What's the total monthly financial gain of https://doi.org/10.1084%2Fjem.186.9.1535?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Interferon%20%28IFN%29%20consensus%20sequence-binding%20protein%2C%20a%20transcription%20factor%20of%20the%20IFN%20regulatory%20factor%20family%2C%20regulates%20immune%20responses%20in%20vivo%20through%20control%20of%20interleukin%2012%20expression&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.186.9.1535&volume=186&pages=1535-1546&publication_year=1997&author=Giese%2CNA have monthly?
- How much does https://doi.org/10.1016%2FS1074-7613%2800%2980444-6 bring in each month?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Interferon%20regulatory%20factor-1%20is%20required%20for%20a%20T%20helper%201%20immune%20response%20in%20vivo&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980444-6&volume=6&pages=681-689&publication_year=1997&author=Lohoff%2CM each month?
- What is the earnings of https://doi.org/10.1084%2Fjem.192.3.325?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Deficiency%20in%20the%20transcription%20factor%20interferon%20regulatory%20factor%20%28IRF%29-2%20leads%20to%20severely%20compromised%20development%20of%20natural%20killer%20and%20T%20helper%20type%201%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.192.3.325&volume=192&pages=325-336&publication_year=2000&author=Lohoff%2CM each month?
- Get to know what's the income of https://doi.org/10.1084%2Fjem.186.9.1523
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Interferon%20consensus%20sequence%20binding%20protein-deficient%20mice%20display%20impaired%20resistance%20to%20intracellular%20infection%20due%20to%20a%20primary%20defect%20in%20interleukin%2012%20p40%20induction&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.186.9.1523&volume=186&pages=1523-1534&publication_year=1997&author=Scharton%2CKT&author=Contursi%2CC&author=Masumi%2CA&author=Sher%2CA&author=Ozato%2CK?
- How much does https://doi.org/10.1016%2FS1074-7613%2800%2980443-4 rake in every month?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Multistage%20regulation%20of%20TH1-type%20immune%20responses%20by%20the%20transcription%20factor%20IRF-1&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2980443-4&volume=6&pages=673-679&publication_year=1997&author=Taki%2CS have monthly?
- What's the financial gain of https://doi.org/10.1074%2Fjbc.M205895200?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Modulation%20of%20T%20cell%20cytokine%20production%20by%20interferon%20regulatory%20factor-4&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M205895200&volume=277&pages=49238-49246&publication_year=2002&author=Hu%2CCM&author=Jang%2CSY&author=Fanzo%2CJC&author=Pernis%2CAB
- How much profit is https://doi.org/10.1073%2Fpnas.182425099 making per month?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Dysregulated%20T%20helper%20cell%20differentiation%20in%20the%20absence%20of%20interferon%20regulatory%20factor%204&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.182425099&volume=99&pages=11808-11812&publication_year=2002&author=Lohoff%2CM?
- https://doi.org/10.1084%2Fjem.20011128's total income per month
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Interferon%20regulatory%20factor%204%20%28IRF4%29%20interacts%20with%20NFATc2%20to%20modulate%20interleukin%204%20gene%20expression&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20011128&volume=195&pages=1003-1012&publication_year=2002&author=Rengarajan%2CJ?
- Find out how much https://doi.org/10.1084%2Fjem.20040182 earns monthly
- See how much http://scholar.google.com/scholar_lookup?&title=Enhanced%20TCR-induced%20apoptosis%20in%20interferon%20regulatory%20factor%204-deficient%20CD4%2B%20Th%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20040182&volume=200&pages=247-253&publication_year=2004&author=Lohoff%2CM makes per month
- How much profit does https://doi.org/10.1084%2Fjem.20061308 generate?
- How much income does http://scholar.google.com/scholar_lookup?&title=Interleukin%20%28IL%29-22%20and%20IL-17%20are%20coexpressed%20by%20TH17%20cells%20and%20cooperatively%20enhance%20expression%20of%20antimicrobial%20peptides%201&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20061308&volume=203&pages=2271-2279&publication_year=2006&author=Liang%2CSC have?
- How much does https://doi.org/10.4049%2Fjimmunol.175.2.959 gross monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Lipopolysaccharide%20injection%20induces%20relapses%20of%20experimental%20autoimmune%20encephalomyelitis%20in%20nontransgenic%20mice%20via%20bystander%20activation%20of%20autoreactive%20CD4%2B%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.175.2.959&volume=175&pages=959-966&publication_year=2005&author=Nogai%2CA make?
- How much revenue does https://doi.org/10.1084%2Fjem.20030152 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Conversion%20of%20peripheral%20CD4%2BCD25%E2%88%92%20naive%20T%20cells%20to%20CD4%2BCD25%2B%20regulatory%20T%20cells%20by%20TGF-%CE%B2%20induction%20of%20transcription%20factor%20Foxp3&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20030152&volume=198&pages=1875-1886&publication_year=2003&author=Chen%2CW generate monthly?
- What's the financial gain of https://doi.org/10.1016%2Fj.cell.2006.05.042?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=FOXP3%20controls%20regulatory%20T%20cell%20function%20through%20cooperation%20with%20NFAT&journal=Cell&doi=10.1016%2Fj.cell.2006.05.042&volume=126&pages=375-387&publication_year=2006&author=Wu%2CY
- What is the earnings of https://doi.org/10.1126%2Fscience.1079490?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Control%20of%20regulatory%20T%20cell%20development%20by%20the%20transcription%20factor%20Foxp3&journal=Science&doi=10.1126%2Fscience.1079490&volume=299&pages=1057-1061&publication_year=2003&author=Hori%2CS&author=Nomura%2CT&author=Sakaguchi%2CS?
- Financial intake of https://doi.org/10.1074%2Fjbc.C600321200
- How much income does http://scholar.google.com/scholar_lookup?&title=STAT3%20regulates%20cytokine-mediated%20generation%20of%20inflammatory%20helper%20T%20cells%201&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.C600321200&volume=282&pages=9358-9363&publication_year=2007&author=Yang%2CXO have?
- Get to know https://doi.org/10.1371%2Fjournal.pbio.0050038's earnings
- How much income is http://scholar.google.com/scholar_lookup?&title=Epigenetic%20control%20of%20the%20foxp3%20locus%20in%20regulatory%20T%20cells%201&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0050038&volume=5&publication_year=2007&author=Floess%2CS earning monthly?
- Get to know what's the income of https://doi.org/10.4049%2Fjimmunol.176.6.3593
- How profitable is http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20underlying%20FOXP3%20induction%20in%20human%20T%20cells%201&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.176.6.3593&volume=176&pages=3593-3602&publication_year=2006&author=Mantel%2CPY?
- How much does https://doi.org/10.1182%2Fblood-2006-02-004747 rake in every month?
- How much does http://scholar.google.com/scholar_lookup?&title=IL-2%20regulates%20FOXP3%20expression%20in%20human%20CD4%2BCD25%2B%20regulatory%20T%20cells%20through%20a%20STAT-dependent%20mechanism%20and%20induces%20the%20expansion%20of%20these%20cells%20in%20vivo&journal=Blood&doi=10.1182%2Fblood-2006-02-004747&volume=108&pages=1571-1579&publication_year=2006&author=Zorn%2CE pull in?
- How much does https://doi.org/10.1101%2Fgad.10.18.2335 rake in every month?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Pip%2C%20a%20lymphoid-restricted%20IRF%2C%20contains%20a%20regulatory%20domain%20that%20is%20important%20for%20autoinhibition%20and%20ternary%20complex%20formation%20with%20the%20Ets%20factor%20PU.1&journal=Genes%20Dev.&doi=10.1101%2Fgad.10.18.2335&volume=10&pages=2335-2347&publication_year=1996&author=Brass%2CAL&author=Kehrli%2CE&author=Eisenbeis%2CCF&author=Storb%2CU&author=Singh%2CH?
- How much money does https://doi.org/10.1084%2Fjem.190.12.1837 generate?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Lineage-specific%20modulation%20of%20interleukin%204%20signaling%20by%20interferon%20regulatory%20factor%204&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.190.12.1837&volume=190&pages=1837-1848&publication_year=1999&author=Gupta%2CS&author=Jiang%2CM&author=Anthony%2CA&author=Pernis%2CAB?
- https://doi.org/10.1016%2FS1074-7613%2800%2900078-9 income
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20TH1%20differentiation%20by%20IL-6%20is%20mediated%20by%20SOCS1&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2900078-9&volume=13&pages=805-815&publication_year=2000&author=Diehl%2CS?
- How much revenue does https://doi.org/10.1084%2Fjem.185.3.461 produce monthly?
- See how much http://scholar.google.com/scholar_lookup?&title=Interleukin%20%28IL%29-6%20directs%20the%20differentiation%20of%20IL-4-producing%20CD4%2B%20T%20cells&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.185.3.461&volume=185&pages=461-469&publication_year=1997&author=Rincon%2CM&author=Anguita%2CJ&author=Nakamura%2CT&author=Fikrig%2CE&author=Flavell%2CRA makes per month
- How much cash flow does https://doi.org/10.1016%2Fj.jneuroim.2006.06.026 have monthly?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20autoimmune%20encephalomyelitis%20by%20a%20neurokinin-1%20receptor%20antagonist%E2%80%93a%20putative%20role%20for%20substance%20P%20in%20CNS%20inflammation&journal=J.%20Neuroimmunol.&doi=10.1016%2Fj.jneuroim.2006.06.026&volume=179&pages=1-8&publication_year=2006&author=Nessler%2CS?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10490973
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Cross-reactivity%20of%20myelin%20basic%20protein-specific%20T%20cells%20with%20multiple%20microbial%20peptides%3A%20experimental%20autoimmune%20encephalomyelitis%20induction%20in%20TCR%20transgenic%20mice&journal=J.%20Immunol.&volume=163&pages=3764-3770&publication_year=1999&author=Grogan%2CJL
- What are the earnings of https://citation-needed.springer.com/v2/references/10.1038/ni1500?format=refman&flavour=references?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anne%20Br%C3%BCstle earn?
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anne%20Br%C3%BCstle%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sylvia%20Heink's earnings
- What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sylvia%20Heink%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Magdalena%20Huber rake in every month?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Magdalena%20Huber%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christine%20Rosenpl%C3%A4nter generate monthly?
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christine%20Rosenpl%C3%A4nter%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christine%20Stadelmann?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christine%20Stadelmann%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Philipp%20Yu?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Philipp%20Yu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Enrico%20Arpaia
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Enrico%20Arpaia%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tak%20W%20Mak have?
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tak%20W%20Mak%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Thomas%20Kamradt make?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Thomas%20Kamradt%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Lohoff making per month?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Lohoff%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's the income of https://static-content.springer.com/esm/art%3A10.1038%2Fni1500/MediaObjects/41590_2007_BFni1500_MOESM26_ESM.pdf?
- What's the monthly money flow for https://s100.copyright.com/AppDispatchServlet?title=The%20development%20of%20inflammatory%20TH-17%20cells%20requires%20interferon-regulatory%20factor%204&author=Anne%20Br%C3%BCstle%20et%20al&contentID=10.1038%2Fni1500©right=Springer%20Nature%20America%2C%20Inc.&publication=1529-2908&publicationDate=2007-08-05&publisherName=SpringerNature&orderBeanReset=true?
- Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1038/ni1500?format=refman&flavour=citation
- https://doi.org/10.1007/s13671-024-00433-z's total income per month
- What's the financial intake of https://doi.org/10.1007/s12026-022-09353-1?
- How much does https://doi.org/10.1186/s12974-022-02675-9 rake in every month?
- How much does https://doi.org/10.1038/s41467-022-28172-4 gross monthly?
- Check the income stats for https://doi.org/10.1038/s41467-022-30053-9
- How much does https://www.protocols.io/ bring in each month?
- Monthly income for https://www.natureindex.com/
- How profitable is http://www.naturechina.com?
- Get to know https://www.natureasia.com/ja-jp's earnings
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref