DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://www.nature.com/articles/ni.2031, but it redirected us to https://www.nature.com/articles/ni.2031. The analysis below is for the second page.

Title[redir]:
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF | Nature Immunology
Description:
The development of experimental autoimmune encephalomyelitis has been attributed to cells of the TH1 or TH17 subset of helper T cells. Becher and Rostami and their colleagues show that IL-23-induced production of the cytokine GM-CSF underlies disease development and severity. Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in TH17 cells and that GM-CSF had an essential role in their encephalitogenicity. Our findings identify a chief mechanism that underlies the important role of IL-23 in autoimmune diseases. IL-23 induced a positive feedback loop whereby GM-CSF secreted by TH17 cells stimulated the production of IL-23 by antigen-presenting cells. Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies TH17 cells as a crucial source of GM-CSF in autoimmune inflammation.

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 96,105,781 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, article, cas, google, scholar, cells, nature, immunol, autoimmune, central, gmcsf, production, access, content, cytokine, ilproducing, encephalomyelitis, interleukin, development, cell, nat, receptor, essential, cookies, immunology, helper, differentiation, inflammatory, privacy, elbehi, ciric, factor, inflammation, experimental, exp, med, data, information, journal, encephalitogenicity, rostami, colonystimulating, autoimmunity, pathogenic, regulatory, sci, usa, lineage, mice, required,

Topics {✒️}

nature portfolio permissions reprints privacy policy granulocyte-macrophage colony-stimulating factor advertising il-1/il-1r antagonist system social media data protection nature 441 nature 448 nature 421 nature 467 nature article el-behi guang-xian zhang author correspondence central nervous system personal data th17-driven inflammatory disease 17 cell-mediated pathology experimental autoimmune encephalomyelitis springerlink instant access gm-csf mediates autoimmunity permissions anti-gm-csf ameliorates autoimmune encephalomyelitis microbial lipopeptides induce adult mouse microglia cytokine gm-csf reciprocal developmental pathways il-9 induces differentiation peripherally derived monocytes transcription factor activities privacy gm-csf explains autoimmune neuro-inflammation cell surface receptor competing financial interests gm-csf production gm-csf secreted interleukin-6 mrna induced pathogenic th17 cells il-23-induced production il-23 induced production abdolmohamad rostami il-23-dependent fashion il-17-producing cells pathogenic effector th17 t-bet regulates autoimmune diseases

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
         description:The development of experimental autoimmune encephalomyelitis has been attributed to cells of the TH1 or TH17 subset of helper T cells. Becher and Rostami and their colleagues show that IL-23-induced production of the cytokine GM-CSF underlies disease development and severity. Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in TH17 cells and that GM-CSF had an essential role in their encephalitogenicity. Our findings identify a chief mechanism that underlies the important role of IL-23 in autoimmune diseases. IL-23 induced a positive feedback loop whereby GM-CSF secreted by TH17 cells stimulated the production of IL-23 by antigen-presenting cells. Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies TH17 cells as a crucial source of GM-CSF in autoimmune inflammation.
         datePublished:2011-04-24T00:00:00Z
         dateModified:2011-04-24T00:00:00Z
         pageStart:568
         pageEnd:575
         sameAs:https://doi.org/10.1038/ni.2031
         keywords:
            Autoimmune diseases
            Cytokines
            Immunopathogenesis
            T-helper 17 cells
            Biomedicine
            general
            Immunology
            Infectious Diseases
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig6_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig7_HTML.jpg
         isPartOf:
            name:Nature Immunology
            issn:
               1529-2916
               1529-2908
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Mohamed El-Behi
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bogoljub Ciric
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hong Dai
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yaping Yan
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Melissa Cullimore
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Farinaz Safavi
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guang-Xian Zhang
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bonnie N Dittel
               affiliation:
                     name:Blood Research Institute, Blood Center of Wisconsin
                     address:
                        name:Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abdolmohamad Rostami
               affiliation:
                     name:Thomas Jefferson University
                     address:
                        name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
      description:The development of experimental autoimmune encephalomyelitis has been attributed to cells of the TH1 or TH17 subset of helper T cells. Becher and Rostami and their colleagues show that IL-23-induced production of the cytokine GM-CSF underlies disease development and severity. Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in TH17 cells and that GM-CSF had an essential role in their encephalitogenicity. Our findings identify a chief mechanism that underlies the important role of IL-23 in autoimmune diseases. IL-23 induced a positive feedback loop whereby GM-CSF secreted by TH17 cells stimulated the production of IL-23 by antigen-presenting cells. Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies TH17 cells as a crucial source of GM-CSF in autoimmune inflammation.
      datePublished:2011-04-24T00:00:00Z
      dateModified:2011-04-24T00:00:00Z
      pageStart:568
      pageEnd:575
      sameAs:https://doi.org/10.1038/ni.2031
      keywords:
         Autoimmune diseases
         Cytokines
         Immunopathogenesis
         T-helper 17 cells
         Biomedicine
         general
         Immunology
         Infectious Diseases
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig6_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.2031/MediaObjects/41590_2011_Article_BFni2031_Fig7_HTML.jpg
      isPartOf:
         name:Nature Immunology
         issn:
            1529-2916
            1529-2908
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mohamed El-Behi
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bogoljub Ciric
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hong Dai
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yaping Yan
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Melissa Cullimore
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Farinaz Safavi
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guang-Xian Zhang
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bonnie N Dittel
            affiliation:
                  name:Blood Research Institute, Blood Center of Wisconsin
                  address:
                     name:Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abdolmohamad Rostami
            affiliation:
                  name:Thomas Jefferson University
                  address:
                     name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Immunology
      issn:
         1529-2916
         1529-2908
      volumeNumber:12
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
      name:Blood Research Institute, Blood Center of Wisconsin
      address:
         name:Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
         type:PostalAddress
      name:Thomas Jefferson University
      address:
         name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mohamed El-Behi
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Bogoljub Ciric
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Hong Dai
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Yaping Yan
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Melissa Cullimore
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Farinaz Safavi
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Guang-Xian Zhang
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Bonnie N Dittel
      affiliation:
            name:Blood Research Institute, Blood Center of Wisconsin
            address:
               name:Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
               type:PostalAddress
            type:Organization
      name:Abdolmohamad Rostami
      affiliation:
            name:Thomas Jefferson University
            address:
               name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
      name:Blood Research Institute, Blood Center of Wisconsin, Milwaukee, USA
      name:Department of Neurology, Thomas Jefferson University, Philadelphia, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

https://twitter.com/NatImmunol

External Links {🔗}(290)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Foundation
Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

4.6s.