
NCBI . NLM . NIH . GOV {
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Title[redir]:
GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival - PMC
Description:
Granulocyte macrophage–colony stimulating factor (GM-CSF) is critically involved in development of organ-related autoimmune inflammatory diseases including experimental allergic encephalitis and collagen-induced arthritis. Roles of GM-CSF in the ...
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Keywords {🔍}
cells, gmcsf, mice, cell, pubmed, google, scholar, fig, doi, autoimmune, development, production, day, myocarditis, proliferation, data, pmc, immunization, reduced, shown, vivo, immunized, article, cytokines, stimulation, free, differentiation, presence, immunol, inflammatory, activation, isolated, survival, activated, purified, role, macrophages, ifnγ, vitro, measured, expression, dogmcsf, experimental, disease, found, results, inflammation, cpg, med, factor,
Topics {✒️}
5-bromo-4-chloro-3-indol-phosphate-toluidine/nitroblue-tetrazoliumchloride granulocyte-macrophage colony-stimulating factor granulocyte/macrophage colony-stimulating factor affinity chromatography–purified anti–ifn-γ alkaline-phosphatase–labeled anti–mouse igg org/cgi/content/full/jem 2 μg/ml anti–ifn-γ−biotin ifn-γ+il-17+ double producers inhibits tgf-β–induced treg 10/gm-csf+/+cd4+→gm-csf+/+ mice 10/gm-csf−/− cd4+→gm-csf−/− mice myhcα/cfa-immunized gm-csf−/− mice collagen-induced arthritis post-onset gm-csf–derived bm-dc activated experimental allergic encephalitis pmc beta search organ-related autoimmunity similar gm-csf sustains il-6–mediated anti–gm-csf therapy 20 ng/ml rgm-csf antigen-specific gm-csf−/− cd4+ gm-csf–blocking antibody failed il-17+ifn-γ+ cd4 populations alkaline-phosphatase–labeled streptavidin adding recombinant gm-csf interleukin-12 receptor/stat4 signaling organ-related autoimmune retrovirally transduced antigen-specific ifn-γ+il-17+ cells specific pmc copyright notice cd4+cd8+tcrlo thymocytes gm-csf–competent mice gm-csf mrna correlated myosin-induced acute myocarditis gm-csf−/− heart sections produce detectable gm-csf unlabeled capture anti–il-6 gm-csf−/− recipients irrespective gm-csf regulates cd4 gm-csf–deficient mice populations secreting gm-csf gm-csf promoted autoimmunity gm-csf–competent cd4+ 20 ng/ml gm-csf tailed mann-whitney test restore full-blown eam gm-csf–deficient cultures ifn-γ–producing cells determined specific spot-forming cells produce gm-csf directly
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