
DOI . ORG {
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Title[redir]:
The molecular landscape of glioma in patients with Neurofibromatosis 1 | Nature Medicine
Description:
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
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Keywords {🔍}
pubmed, google, scholar, cas, central, data, glioma, cancer, nature, somatic, neurofibromatosis, university, department, nfglioma, mutation, dna, france, tumor, samples, tumors, alterations, gene, sequencing, patients, mutations, analysis, article, type, bioinformatics, usa, center, extended, fig, atrx, access, human, hospital, immune, nat, hum, cell, paris, source, genetic, gliomas, mutational, genomic, supplementary, med, res,
Topics {✒️}
supplementary data file supplementary information nature portfolio journals permissions reprints supplementary table 6a nature portfolio privacy policy supplementary table 7 cancer research center high-throughput sequencing data extended data fig advertising population-based record-linkage study rna-seq data service de neurochirurgie cancer research social media transcriptomic data supporting multivariate count data generation sequencing data nf1-glioma data low-grade nf1-gliomas displayed service de génétique haplotype-based variant detection personal data expression data data types tcga data wes data data protection coverage data fgfr3-tacc3 gene fusions nature+ nature 555 nature 482 nature 553 nature 500 nature 526 nature amino acid insertions/deletions sequence alignment/map format increased neo-antigen load tcga pan-glioma dataset copy-number variation discovery rna-seq sequence reads single-cell transcriptomes identifies panels low-grade glioma data information anderson cancer center
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headline:The molecular landscape of glioma in patients with Neurofibromatosis 1
description:Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
datePublished:2018-12-10T00:00:00Z
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Cancer
Cancer genomics
CNS cancer
Biomedicine
general
Cancer Research
Metabolic Diseases
Infectious Diseases
Molecular Medicine
Neurosciences
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