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We began analyzing https://www.nature.com/articles/s41591-018-0263-8, but it redirected us to https://www.nature.com/articles/s41591-018-0263-8. The analysis below is for the second page.

Title[redir]:
The molecular landscape of glioma in patients with Neurofibromatosis 1 | Nature Medicine
Description:
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

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Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, google, scholar, cas, central, data, glioma, cancer, nature, somatic, neurofibromatosis, university, department, nfglioma, mutation, dna, france, tumor, samples, tumors, alterations, gene, sequencing, patients, mutations, analysis, article, type, bioinformatics, usa, center, extended, fig, atrx, access, human, hospital, immune, nat, hum, cell, paris, source, genetic, gliomas, mutational, genomic, supplementary, med, res,

Topics {✒️}

supplementary data file supplementary information nature portfolio journals permissions reprints supplementary table 6a nature portfolio privacy policy supplementary table 7 cancer research center high-throughput sequencing data extended data fig advertising population-based record-linkage study rna-seq data service de neurochirurgie cancer research social media transcriptomic data supporting multivariate count data generation sequencing data nf1-glioma data low-grade nf1-gliomas displayed service de génétique haplotype-based variant detection personal data expression data data types tcga data wes data data protection coverage data fgfr3-tacc3 gene fusions nature+ nature 555 nature 482 nature 553 nature 500 nature 526 nature amino acid insertions/deletions sequence alignment/map format increased neo-antigen load tcga pan-glioma dataset copy-number variation discovery rna-seq sequence reads single-cell transcriptomes identifies panels low-grade glioma data information anderson cancer center

Schema {🗺️}

WebPage:
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         headline:The molecular landscape of glioma in patients with Neurofibromatosis 1
         description:Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
         datePublished:2018-12-10T00:00:00Z
         dateModified:2018-12-21T00:00:00Z
         pageStart:176
         pageEnd:187
         sameAs:https://doi.org/10.1038/s41591-018-0263-8
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            Cancer
            Cancer genomics
            CNS cancer
            Biomedicine
            general
            Cancer Research
            Metabolic Diseases
            Infectious Diseases
            Molecular Medicine
            Neurosciences
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            name:Nature Medicine
            issn:
               1546-170X
               1078-8956
            volumeNumber:25
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               name:Marc Sanson
               affiliation:
                     name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
                     address:
                        name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anna Lasorella
               url:http://orcid.org/0000-0002-1839-5421
               affiliation:
                     name:Columbia University Medical Center
                     address:
                        name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Columbia University Medical Center
                     address:
                        name:Department of Pediatrics, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Columbia University Medical Center
                     address:
                        name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Antonio Iavarone
               url:http://orcid.org/0000-0002-0683-4634
               affiliation:
                     name:Columbia University Medical Center
                     address:
                        name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Columbia University Medical Center
                     address:
                        name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Columbia University Medical Center
                     address:
                        name:Department of Neurology, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
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ScholarlyArticle:
      headline:The molecular landscape of glioma in patients with Neurofibromatosis 1
      description:Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
      datePublished:2018-12-10T00:00:00Z
      dateModified:2018-12-21T00:00:00Z
      pageStart:176
      pageEnd:187
      sameAs:https://doi.org/10.1038/s41591-018-0263-8
      keywords:
         Cancer
         Cancer genomics
         CNS cancer
         Biomedicine
         general
         Cancer Research
         Metabolic Diseases
         Infectious Diseases
         Molecular Medicine
         Neurosciences
      image:
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      isPartOf:
         name:Nature Medicine
         issn:
            1546-170X
            1078-8956
         volumeNumber:25
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fulvio D’Angelo
            url:http://orcid.org/0000-0002-4940-4693
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’
                  address:
                     name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michele Ceccarelli
            url:http://orcid.org/0000-0002-4702-6617
            affiliation:
                  name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’
                  address:
                     name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
                     type:PostalAddress
                  type:Organization
                  name:Università degli Studi del Sannio
                  address:
                     name:Department of Science and Technology, Università degli Studi del Sannio, Benevento, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tala
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Luciano Garofano
            url:http://orcid.org/0000-0001-8582-0865
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’
                  address:
                     name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Zhang
            url:http://orcid.org/0000-0001-8549-3286
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Véronique Frattini
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francesca P. Caruso
            affiliation:
                  name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’
                  address:
                     name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
                     type:PostalAddress
                  type:Organization
                  name:Università degli Studi del Sannio
                  address:
                     name:Department of Science and Technology, Università degli Studi del Sannio, Benevento, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Genevieve Lewis
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kristin D. Alfaro
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center John Mendelsohn Faculty Center (FC7.3025) – Neuro-Oncology – Unit 0431
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center John Mendelsohn Faculty Center (FC7.3025) – Neuro-Oncology – Unit 0431, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Luc Bauchet
            affiliation:
                  name:Montpellier University Medical Center
                  address:
                     name:Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Giulia Berzero
            affiliation:
                  name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
                  address:
                     name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Cachia
            affiliation:
                  name:Medical University of South Carolina
                  address:
                     name:Department of Neuro-Oncology, Medical University of South Carolina, Charleston, USA
                     type:PostalAddress
                  type:Organization
                  name:Medical University of South Carolina
                  address:
                     name:Department of Neurosurgery, Medical University of South Carolina, Charleston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mario Cangiano
            affiliation:
                  name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’
                  address:
                     name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laurent Capelle
            affiliation:
                  name:AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurochirurgie
                  address:
                     name:AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurochirurgie, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John de Groot
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francesco DiMeco
            affiliation:
                  name:Carlo Besta Neurological Institute
                  address:
                     name:Department of Neurological Surgery, Carlo Besta Neurological Institute, Milan, Italy
                     type:PostalAddress
                  type:Organization
                  name:University of Milan
                  address:
                     name:Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
                     type:PostalAddress
                  type:Organization
                  name:Hunterian Brain Tumor Research Laboratory CRB2 2M41
                  address:
                     name:Hunterian Brain Tumor Research Laboratory CRB2 2M41, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:François Ducray
            affiliation:
                  name:Service de Neuro-Oncologie, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Department of Cancer Cell Plasticity, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR5286
                  address:
                     name:Service de Neuro-Oncologie, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Department of Cancer Cell Plasticity, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR5286, Lyon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Walid Farah
            affiliation:
                  name:CHU
                  address:
                     name:Department of Neurosurgery, CHU, Dijon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gaetano Finocchiaro
            url:http://orcid.org/0000-0003-3583-4040
            affiliation:
                  name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute
                  address:
                     name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stéphane Goutagny
            affiliation:
                  name:Assistance Publique-Hôpitaux de Paris
                  address:
                     name:Service de Neurochirurgie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Kamiya-Matsuoka
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cinzia Lavarino
            affiliation:
                  name:Fundación Sant Joan de Déu
                  address:
                     name:Developmental Tumor Laboratory, Fundación Sant Joan de Déu, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hugues Loiseau
            affiliation:
                  name:Bordeaux University Hospital. Labex TRAIL (ANR-10-LABX-57). EA 7435 – IMOTION Bordeaux University
                  address:
                     name:Department of Neurosurgery, Bordeaux University Hospital. Labex TRAIL (ANR-10-LABX-57). EA 7435 – IMOTION Bordeaux University, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Véronique Lorgis
            affiliation:
                  name:Centre GF Leclerc
                  address:
                     name:Department of Medical Oncology, Centre GF Leclerc, Dijon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlo E. Marras
            affiliation:
                  name:Bambino Gesù Children’s Hospital
                  address:
                     name:Pediatric Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children’s Hospital, Rome, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ian McCutcheon
            url:http://orcid.org/0000-0002-1638-3400
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Do-Hyun Nam
            affiliation:
                  name:Sungkyunkwan University School of Medicine
                  address:
                     name:Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Sungkyunkwan University
                  address:
                     name:Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susanna Ronchi
            affiliation:
                  name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
                  address:
                     name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Veronica Saletti
            affiliation:
                  name:Carlo Besta Neurological Institute
                  address:
                     name:Developmental Neurology Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Romuald Seizeur
            affiliation:
                  name:CHRU de Brest, Université de Brest
                  address:
                     name:Service de Neurochirurgie, Hôpital de la Cavale Blanche, CHRU de Brest, Université de Brest, Brest, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Slopis
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mariona Suñol
            affiliation:
                  name:Hospital Sant Joan de Déu
                  address:
                     name:Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fanny Vandenbos
            affiliation:
                  name:Pasteur I University Hospital
                  address:
                     name:Central Laboratory of Pathology, Pasteur I University Hospital, Nice, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pascale Varlet
            affiliation:
                  name:Sainte-Anne Hospital
                  address:
                     name:Department of Neuropathology, Sainte-Anne Hospital, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:IMA-Brain, Inserm U894, Institute of Psychiatry and Neuroscience of Paris
                  address:
                     name:IMA-Brain, Inserm U894, Institute of Psychiatry and Neuroscience of Paris, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dominique Vidaud
            affiliation:
                  name:EA7331, Université Paris Descartes, France; Service de Génétique et Biologie Moléculaires, Hôpital Cochin, AP-HP
                  address:
                     name:EA7331, Université Paris Descartes, France; Service de Génétique et Biologie Moléculaires, Hôpital Cochin, AP-HP, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Colin Watts
            affiliation:
                  name:Institute of Cancer and Genomic Sciences University of Birmingham Edgbaston
                  address:
                     name:Institute of Cancer and Genomic Sciences University of Birmingham Edgbaston, Birmingham, United Kingdom
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Viviane Tabar
            affiliation:
                  name:Memorial Sloan Kettering Cancer Center
                  address:
                     name:Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David E. Reuss
            affiliation:
                  name:Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ)
                  address:
                     name:Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University Hospital
                  address:
                     name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung-Ki Kim
            affiliation:
                  name:Seoul National University Children’s Hospital, Seoul National University College of Medicine
                  address:
                     name:Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Meyronet
            affiliation:
                  name:Centre de Pathologie Et Neuropathologie Est Hospices Civils de Lyon
                  address:
                     name:Centre de Pathologie Et Neuropathologie Est Hospices Civils de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Karima Mokhtari
            affiliation:
                  name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
                  address:
                     name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hector Salvador
            url:http://orcid.org/0000-0002-2515-0019
            affiliation:
                  name:Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues
                  address:
                     name:Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Krishna P. Bhat
            affiliation:
                  name:The University of Texas M.D. Anderson Cancer Center
                  address:
                     name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marica Eoli
            affiliation:
                  name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute
                  address:
                     name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marc Sanson
            affiliation:
                  name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
                  address:
                     name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna Lasorella
            url:http://orcid.org/0000-0002-1839-5421
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Columbia University Medical Center
                  address:
                     name:Department of Pediatrics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Columbia University Medical Center
                  address:
                     name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Antonio Iavarone
            url:http://orcid.org/0000-0002-0683-4634
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Columbia University Medical Center
                  address:
                     name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Columbia University Medical Center
                  address:
                     name:Department of Neurology, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
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      name:Nature Medicine
      issn:
         1546-170X
         1078-8956
      volumeNumber:25
Organization:
      name:Nature Publishing Group US
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               type:PostalAddress
            type:Organization
            name:IMA-Brain, Inserm U894, Institute of Psychiatry and Neuroscience of Paris
            address:
               name:IMA-Brain, Inserm U894, Institute of Psychiatry and Neuroscience of Paris, Paris, France
               type:PostalAddress
            type:Organization
      name:Dominique Vidaud
      affiliation:
            name:EA7331, Université Paris Descartes, France; Service de Génétique et Biologie Moléculaires, Hôpital Cochin, AP-HP
            address:
               name:EA7331, Université Paris Descartes, France; Service de Génétique et Biologie Moléculaires, Hôpital Cochin, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
      name:Colin Watts
      affiliation:
            name:Institute of Cancer and Genomic Sciences University of Birmingham Edgbaston
            address:
               name:Institute of Cancer and Genomic Sciences University of Birmingham Edgbaston, Birmingham, United Kingdom
               type:PostalAddress
            type:Organization
      name:Viviane Tabar
      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
            type:Organization
      name:David E. Reuss
      affiliation:
            name:Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ)
            address:
               name:Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University Hospital
            address:
               name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Seung-Ki Kim
      affiliation:
            name:Seoul National University Children’s Hospital, Seoul National University College of Medicine
            address:
               name:Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:David Meyronet
      affiliation:
            name:Centre de Pathologie Et Neuropathologie Est Hospices Civils de Lyon
            address:
               name:Centre de Pathologie Et Neuropathologie Est Hospices Civils de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
      name:Karima Mokhtari
      affiliation:
            name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
            address:
               name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
               type:PostalAddress
            type:Organization
      name:Hector Salvador
      url:http://orcid.org/0000-0002-2515-0019
      affiliation:
            name:Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues
            address:
               name:Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Krishna P. Bhat
      affiliation:
            name:The University of Texas M.D. Anderson Cancer Center
            address:
               name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Marica Eoli
      affiliation:
            name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute
            address:
               name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Marc Sanson
      affiliation:
            name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP
            address:
               name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
               type:PostalAddress
            type:Organization
      name:Anna Lasorella
      url:http://orcid.org/0000-0002-1839-5421
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
            name:Columbia University Medical Center
            address:
               name:Department of Pediatrics, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
            name:Columbia University Medical Center
            address:
               name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Antonio Iavarone
      url:http://orcid.org/0000-0002-0683-4634
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
            name:Columbia University Medical Center
            address:
               name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
            name:Columbia University Medical Center
            address:
               name:Department of Neurology, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
      name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
      name:Department of Science and Technology, Università degli Studi del Sannio, Benevento, Italy
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
      name:Department of Science and Technology, Università degli Studi del Sannio, Benevento, Italy
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:The University of Texas M.D. Anderson Cancer Center John Mendelsohn Faculty Center (FC7.3025) – Neuro-Oncology – Unit 0431, Houston, USA
      name:Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France
      name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
      name:Department of Neuro-Oncology, Medical University of South Carolina, Charleston, USA
      name:Department of Neurosurgery, Medical University of South Carolina, Charleston, USA
      name:BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Ariano Irpino, Italy
      name:AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurochirurgie, Paris, France
      name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
      name:Department of Neurological Surgery, Carlo Besta Neurological Institute, Milan, Italy
      name:Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
      name:Hunterian Brain Tumor Research Laboratory CRB2 2M41, Baltimore, USA
      name:Service de Neuro-Oncologie, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Department of Cancer Cell Plasticity, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR5286, Lyon, France
      name:Department of Neurosurgery, CHU, Dijon, France
      name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
      name:Service de Neurochirurgie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France
      name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
      name:Developmental Tumor Laboratory, Fundación Sant Joan de Déu, Barcelona, Spain
      name:Department of Neurosurgery, Bordeaux University Hospital. Labex TRAIL (ANR-10-LABX-57). EA 7435 – IMOTION Bordeaux University, Bordeaux, France
      name:Department of Medical Oncology, Centre GF Leclerc, Dijon, France
      name:Pediatric Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children’s Hospital, Rome, Italy
      name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
      name:Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
      name:Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
      name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
      name:Developmental Neurology Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
      name:Service de Neurochirurgie, Hôpital de la Cavale Blanche, CHRU de Brest, Université de Brest, Brest, France
      name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
      name:Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain
      name:Central Laboratory of Pathology, Pasteur I University Hospital, Nice, France
      name:Department of Neuropathology, Sainte-Anne Hospital, Paris, France
      name:IMA-Brain, Inserm U894, Institute of Psychiatry and Neuroscience of Paris, Paris, France
      name:EA7331, Université Paris Descartes, France; Service de Génétique et Biologie Moléculaires, Hôpital Cochin, AP-HP, Paris, France
      name:Institute of Cancer and Genomic Sciences University of Birmingham Edgbaston, Birmingham, United Kingdom
      name:Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, USA
      name:Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
      name:Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
      name:Centre de Pathologie Et Neuropathologie Est Hospices Civils de Lyon, Lyon, France
      name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
      name:Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain
      name:The University of Texas M.D. Anderson Cancer Center, Houston, USA
      name:Unit of Molecular Neuro-Oncology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
      name:Sorbonne Universités UPMC Université Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, APHP, Paris, France
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:Department of Pediatrics, Columbia University Medical Center, New York, USA
      name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
      name:Institute for Cancer Genetics, Columbia University Medical Center, New York, USA
      name:Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA
      name:Department of Neurology, Columbia University Medical Center, New York, USA
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