
NCBI . NLM . NIH . GOV {
}
Title[redir]:
RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth - PMC
Description:
Solid cancers develop within a supportive microenvironment that promotes tumor formation and growth through the elaboration of mitogens and chemokines. Within these tumors, monocytes (macrophages and microglia) represent rich sources of these ...
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Keywords {🔍}
doi, ccl, optic, pubmed, google, scholar, microglia, glioma, cells, expression, pmc, mice, article, free, growth, cell, cancer, brain, human, fmc, figure, rna, tumor, microglial, treatment, murine, increased, tumors, mouse, analysis, ccr, gliomas, nerve, proliferation, relative, nerves, gene, bar, neurofibromatosis, vivo, data, cxcl, chemokine, inactivation, reduced, studies, normal, model, astrocyte, denote,
Topics {✒️}
increased c-jun-nh2-kinase signaling rna-seq paired-end reads met-rantes–treated animals displayed ambion nuclease-free water turbo dna-free kit contributed reagents/materials/analysis tools bone marrow–derived macrophages promote nf1-deficient astrocyte nf1-deficient astrocyte proliferation large-scale discovery effort high-grade glioma growth antibody-mediated flow sorting fluorescence-conjugated secondary antibodies fluorescence-activated cell sorting pmc beta search span exon-exon junctions mouse low-grade glioma rat adjuvant-induced arthritis minocycline-mediated microglial inactivation myeloid-derived suppressor cells vegf-specific antibody bevacizumab pi3k/akt pathway alterations rna-sequencing reveals oligodendrocyte mouse low-grade gliomas anti-ccl5 neutralizing antibodies produce growth/survival factors hrp-conjugated secondary antibodies ovation rna-seq method adenovirus-mediated cre transduction bonferroni post-test correction mtor-dependent mrna translation inflammation-induced chemokine expression amoeboid-shaped monocytic cells double-labeling immunofluorescent microscopy initially employed met-rantes cre/loxp-mediated inactivation low-grade brain tumor resulting low-grade tumors t-cell–dependent mechanism low-grade brain tumors anti-ccl5 treatment resulted normal t-cell–expressed neurofibromatosis-1 regulates neuronal igg control–treated mice tumor-bearing optic nerves anti-ccl5–treated animals mouse optic nerve astrocyte growth media gov/tools/primer-blast/ high-grade glioma
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