
NCBI . NLM . NIH . GOV {
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Title[redir]:
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma - PMC
Description:
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating ...
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Keywords {🔍}
tumors, doi, gcimp, methylation, gene, dna, google, scholar, expression, pubmed, proneural, gbm, cancer, gcimppositive, samples, figure, idh, genes, data, gliomas, pmc, article, status, free, cpg, tumor, tcga, patients, survival, mutation, gcimpnegative, hypermethylation, grade, glioma, table, human, set, cluster, island, subset, mutations, identified, glioblastoma, significantly, primary, number, molecular, cell, genome, promoter,
Topics {✒️}
o6-methylguanine-dna methyltransferase-deficient phenotype g-cimp-positive tumors represent g-cimp-positive tumors showed proneural g-cimp-negative tumors g-cimp-negative proneural tumors proneural g-cimp-positive tumors proneural g-cimp-positive samples proneural g-cimp-negative patients proneural g-cimp-positive patients g-cimp-positive tumors compared g-cimp-positive gbms tumors wilcoxon rank-sum test characteristic copy-number alterations directly catalyzing α-ketoglutarate regulates p85-p110 heterodimerization cellular retinol-binding protein cellular retinol-binding protein trans-retinoic acid production g-cimp negative proneurals remained g-cimp-negative considered g-cimp positive proneural g-cimp-negative g-cimp-negative proneural inhibits pi3k/akt signaling g-cimp-defining hyper proneural g-cimp-positive g-cimp-positive proneural proneural g-cimp positive g-cimp tumors belong pmc beta search [google scholar] sanson g-cimp positivity appeared g-cimp tumors represent 184 g-cimp-negative tumors g-cimp-negative tumors g-cimp negative tumors kaplan-meier survival curves kaplan-meier survival curve g-cimp-positive status g-cimp positive status g-cimp status remained g-cimp-positive tumors g-cimp positive tumors g-cimp-negative cases g-cimp tumors define alkylating agent-based chemotherapy pi3k/akt signaling pathway g-cimp-positive cases g-cimp proneural tumors proneural g-cimp tumors
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