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DOI . ORG {}

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  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
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We began analyzing https://www.nature.com/articles/cddis201293, but it redirected us to https://www.nature.com/articles/cddis201293. The analysis below is for the second page.

Title[redir]:
Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity | Cell Death & Disease
Description:
Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We can't see how the site brings in money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

cells, expression, cancer, figure, cspc, cell, panel, lung, emt, subpopulations, article, nscla, tgfβ, rac, google, scholar, primary, cdpos, aldhhigh, cas, nonsp, left, activity, stem, supplementary, adenocarcinoma, increased, gene, nature, facs, csc, distinct, analysis, selfrenewal, cspcs, represent, plasticity, observed, determined, mice, transition, human, cscs, tumor, isolated, stained, colonization, compared, tumors, aldhlow,

Topics {✒️}

nature portfolio hospital research foundation privacy policy liver tumor development bead-immobilized p21-binding domain advertising immune compromised nod/scid/γc−/− cancer stem/progenitor cell small-cell lung cancer social media author information authors dynamic nature marker-defined cs/pc subpopulations transient nature 0/ reprints figure 1b middle full size image nature nature 1994 nature 2004 nature 2007 nature 2010 nature 2005 aldh1a1-/cd133-/mutant p53 slow-cycling melanoma cells creative commons attribution-noncommercial cobble-stone epithelial morphology tumor-initiating cell propagation distinct cs/pc subpopulations author correspondence primary resected early-stage therapy-resistant tumor cells cs/pc subpopulations vary liver-lodged cancer cells drug-resistant side population cs/pc transition dynamically distinct cs/pc subpopulation anti-rac1 western blotting adherent sphere-forming conditions cancer stem cell middle panel multiple cs/pc subpopulations nscla cs/pc subpopulations single cs/pc subpopulations reveal relative rac1-gtp cytokine-induced killer cells stem cell marker regulate nf-κβ activity tumour cell growth initiating tumour growth

Questions {❓}

  • Cancer stem cells: mirage or reality?

Schema {🗺️}

WebPage:
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         headline:Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
         description:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.
         datePublished:2012-07-19T00:00:00Z
         dateModified:2012-07-19T00:00:00Z
         pageStart:e352
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            Non-small-cell lung cancer
            lung cancer
            cancer stem cells
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            Immunology
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      headline:Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
      description:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.
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         Non-small-cell lung cancer
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         cancer stem cells
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         Biochemistry
         Cell Biology
         Immunology
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         Antibodies
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      name:Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, USA
      name:Molecular Developmental Biology Program, Children’s Hospital Research Foundation, University of Cincinnati, Cincinnati, USA

Social Networks {👍}(1)

External Links {🔗}(227)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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