
NATURE . COM {
}
Title:
Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity | Cell Death & Disease
Description:
Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.
Keywords {🔍}
cells, expression, cancer, figure, cspc, cell, panel, lung, emt, subpopulations, article, nscla, tgfβ, rac, google, scholar, primary, cdpos, aldhhigh, cas, nonsp, left, activity, stem, supplementary, adenocarcinoma, increased, gene, nature, facs, csc, distinct, analysis, selfrenewal, cspcs, represent, plasticity, observed, determined, mice, transition, human, cscs, tumor, isolated, stained, colonization, compared, tumors, aldhlow,
Topics {✒️}
nature portfolio hospital research foundation privacy policy liver tumor development bead-immobilized p21-binding domain advertising immune compromised nod/scid/γc−/− cancer stem/progenitor cell small-cell lung cancer social media author information authors dynamic nature marker-defined cs/pc subpopulations transient nature 0/ reprints figure 1b middle full size image nature nature 1994 nature 2004 nature 2007 nature 2010 nature 2005 aldh1a1-/cd133-/mutant p53 slow-cycling melanoma cells creative commons attribution-noncommercial cobble-stone epithelial morphology tumor-initiating cell propagation distinct cs/pc subpopulations author correspondence primary resected early-stage therapy-resistant tumor cells cs/pc subpopulations vary liver-lodged cancer cells drug-resistant side population cs/pc transition dynamically distinct cs/pc subpopulation anti-rac1 western blotting adherent sphere-forming conditions cancer stem cell middle panel multiple cs/pc subpopulations nscla cs/pc subpopulations single cs/pc subpopulations reveal relative rac1-gtp cytokine-induced killer cells stem cell marker regulate nf-κβ activity tumour cell growth initiating tumour growth
Questions {❓}
- Cancer stem cells: mirage or reality?
Schema {🗺️}
WebPage:
mainEntity:
headline:Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
description:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.
datePublished:2012-07-19T00:00:00Z
dateModified:2012-07-19T00:00:00Z
pageStart:e352
pageEnd:e352
sameAs:https://doi.org/10.1038/cddis.2012.93
keywords:
Non-small-cell lung cancer
lung cancer
cancer stem cells
Rac1
EMT
self-renewal
plasticity
Life Sciences
general
Biochemistry
Cell Biology
Immunology
Cell Culture
Antibodies
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig7_HTML.jpg
isPartOf:
name:Cell Death & Disease
issn:
2041-4889
volumeNumber:3
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:S Akunuru
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Q James Zhai
affiliation:
name:University of Cincinnati
address:
name:Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Y Zheng
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
description:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133pos and ALDHhigh. Using human non-small cell lung adenocarcinoma cell lines and patient-derived primary tumor cells, we demonstrate that SP cells represent a subpopulation distinct from other cancer stem/progenitor cell (CS/PC) populations marked by CD133pos or ALDHhigh. The non-CS/PCs and CS/PCs of each subpopulation are interconvertible. Epithelial-mesenchymal transition (EMT) promotes the formation of CD133pos and ALDHhigh CS/PC subpopulations while suppressing the SP CS/PC subpopulation. Rac1 GTPase activity is significantly increased in cells that have undergone EMT, and targeting Rac1 is effective in inhibiting the dynamic conversion of non-CS/PCs to CS/PCs, as well as the CS/PC activity. These results imply that various subpopulations of CS/PCs and non-CS/PCs may achieve a stochastic equilibrium in a defined microenvironment, and eliminating multiple subpopulations of CS/PCs and effectively blocking non-CS/PC to CS/PC transition, by an approach such as targeting Rac1, can be a more effective therapy.
datePublished:2012-07-19T00:00:00Z
dateModified:2012-07-19T00:00:00Z
pageStart:e352
pageEnd:e352
sameAs:https://doi.org/10.1038/cddis.2012.93
keywords:
Non-small-cell lung cancer
lung cancer
cancer stem cells
Rac1
EMT
self-renewal
plasticity
Life Sciences
general
Biochemistry
Cell Biology
Immunology
Cell Culture
Antibodies
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_Article_BFcddis201293_Fig7_HTML.jpg
isPartOf:
name:Cell Death & Disease
issn:
2041-4889
volumeNumber:3
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:S Akunuru
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Q James Zhai
affiliation:
name:University of Cincinnati
address:
name:Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Y Zheng
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Cell Death & Disease
issn:
2041-4889
volumeNumber:3
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:University of Cincinnati
address:
name:Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:S Akunuru
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Q James Zhai
affiliation:
name:University of Cincinnati
address:
name:Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Y Zheng
affiliation:
name:Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati
address:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati
address:
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
name:Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, USA
name:Division of Experimental Hematology and Cancer Biology, Childrenâs Hospital Research Foundation, Childrenâs Hospital Medical Center, University of Cincinnati, Cincinnati, USA
name:Molecular Developmental Biology Program, Childrenâs Hospital Research Foundation, University of Cincinnati, Cincinnati, USA
External Links {🔗}(92)
- Check the income stats for https://doi.org/10.1016%2Fj.cell.2009.08.017
- How much money does http://scholar.google.com/scholar_lookup?&title=Heterogeneity%20in%20cancer%3A%20cancer%20stem%20cells%20versus%20clonal%20evolution&journal=Cell&doi=10.1016%2Fj.cell.2009.08.017&volume=138&pages=822-829&publication_year=2009&author=Shackleton%2CM&author=Quintana%2CE&author=Fearon%2CER&author=Morrison%2CSJ make?
- How much profit does https://doi.org/10.1038%2Fsj.cdd.4402283 generate?
- How much money does http://scholar.google.com/scholar_lookup?&title=Identification%20and%20expansion%20of%20the%20tumorigenic%20lung%20cancer%20stem%20cell%20population&journal=Cell%20Death%20Differ&doi=10.1038%2Fsj.cdd.4402283&volume=15&pages=504-514&publication_year=2008&author=Eramo%2CA&author=Lotti%2CF&author=Sette%2CG&author=Pilozzi%2CE&author=Biffoni%2CM&author=Di%20Virgilio%2CA make?
- How much does https://doi.org/10.1158%2F0008-5472.CAN-06-3557 net monthly?
- How much income is http://scholar.google.com/scholar_lookup?&title=Side%20population%20in%20human%20lung%20cancer%20cell%20lines%20and%20tumors%20is%20enriched%20with%20stem-like%20cancer%20cells&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-06-3557&volume=67&pages=4827-4833&publication_year=2007&author=Ho%2CMM&author=Ng%2CAV&author=Lam%2CS&author=Hung%2CJY earning monthly?
- Financial intake of https://doi.org/10.1016%2Fj.ijrobp.2011.06.1999
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Role%20of%20insulin-like%20growth%20factor-1%20signaling%20pathway%20in%20Cisplatin-resistant%20lung%20cancer%20cells&journal=Int%20J%20Radiat%20Oncol%20Biol%20Phys&doi=10.1016%2Fj.ijrobp.2011.06.1999&volume=82&pages=e563-e572&publication_year=2012&author=Sun%2CY&author=Zheng%2CS&author=Torossian%2CA&author=Speirs%2CCK&author=Schleicher%2CS&author=Giacalone%2CNJ
- How much revenue does https://doi.org/10.1038%2F367645a0 bring in?
- Find out how much http://scholar.google.com/scholar_lookup?&title=A%20cell%20initiating%20human%20acute%20myeloid%20leukaemia%20after%20transplantation%20into%20SCID%20mice&journal=Nature&doi=10.1038%2F367645a0&volume=367&pages=645-648&publication_year=1994&author=Lapidot%2CT&author=Sirard%2CC&author=Vormoor%2CJ&author=Murdoch%2CB&author=Hoang%2CT&author=Caceres-Cortes%2CJ earns monthly
- How much does https://doi.org/10.1038%2Fnature03128 net monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20human%20brain%20tumour%20initiating%20cells&journal=Nature&doi=10.1038%2Fnature03128&volume=432&pages=396-401&publication_year=2004&author=Singh%2CSK&author=Hawkins%2CC&author=Clarke%2CID&author=Squire%2CJA&author=Bayani%2CJ&author=Hide%2CT make?
- How much money does https://doi.org/10.1073%2Fpnas.0530291100 generate?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Prospective%20identification%20of%20tumorigenic%20breast%20cancer%20cells&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0530291100&volume=100&pages=3983-3988&publication_year=2003&author=Al-Hajj%2CM&author=Wicha%2CMS&author=Benito-Hernandez%2CA&author=Morrison%2CSJ&author=Clarke%2CMF?
- How much does https://doi.org/10.1038%2Fnature05372 bring in each month?
- Earnings of http://scholar.google.com/scholar_lookup?&title=A%20human%20colon%20cancer%20cell%20capable%20of%20initiating%20tumour%20growth%20in%20immunodeficient%20mice&journal=Nature&doi=10.1038%2Fnature05372&volume=445&pages=106-110&publication_year=2007&author=O%E2%80%B2Brien%2CCA&author=Pollett%2CA&author=Gallinger%2CS&author=Dick%2CJE
- What are the earnings of https://doi.org/10.1002%2Fhep.21227?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Side%20population%20purified%20from%20hepatocellular%20carcinoma%20cells%20harbors%20cancer%20stem%20cell-like%20properties&journal=Hepatology&doi=10.1002%2Fhep.21227&volume=44&pages=240-251&publication_year=2006&author=Chiba%2CT&author=Kita%2CK&author=Zheng%2CYW&author=Yokosuka%2CO&author=Saisho%2CH&author=Iwama%2CA
- Find out how much https://doi.org/10.1371%2Fjournal.pone.0016951 earns monthly
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Rac1%20targeting%20suppresses%20human%20non-small%20cell%20lung%20adenocarcinoma%20cancer%20stem%20cell%20activity&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0016951&volume=6&publication_year=2011&author=Akunuru%2CS&author=Palumbo%2CJ&author=Zhai%2CQJ&author=Zheng%2CY?
- Profit of https://doi.org/10.1371%2Fjournal.pone.0003077
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Drug-selected%20human%20lung%20cancer%20stem%20cells%3A%20cytokine%20network%2C%20tumorigenic%20and%20metastatic%20properties&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0003077&volume=3&publication_year=2008&author=Levina%2CV&author=Marrangoni%2CAM&author=DeMarco%2CR&author=Gorelik%2CE&author=Lokshin%2CAE each month?
- Revenue of https://doi.org/10.1371%2Fjournal.pone.0010277
- How much profit does http://scholar.google.com/scholar_lookup?&title=Distinct%20expression%20levels%20and%20patterns%20of%20stem%20cell%20marker%2C%20aldehyde%20dehydrogenase%20isoform%201%20%28ALDH1%29%2C%20in%20human%20epithelial%20cancers&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0010277&volume=5&publication_year=2010&author=Deng%2CS&author=Yang%2CX&author=Lassus%2CH&author=Liang%2CS&author=Kaur%2CS&author=Ye%2CQ generate?
- Find out how much https://doi.org/10.1158%2F0008-5472.CAN-10-0881 earns monthly
- Find out how much http://scholar.google.com/scholar_lookup?&title=Aldehyde%20dehydrogenase%20activity%20selects%20for%20lung%20adenocarcinoma%20stem%20cells%20dependent%20on%20notch%20signaling&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-10-0881&volume=70&pages=9937-9948&publication_year=2010&author=Sullivan%2CJP&author=Spinola%2CM&author=Dodge%2CM&author=Raso%2CMG&author=Behrens%2CC&author=Gao%2CB earns monthly
- How much income does https://doi.org/10.1016%2Fj.cell.2009.06.034 have?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Identification%20of%20selective%20inhibitors%20of%20cancer%20stem%20cells%20by%20high-throughput%20screening&journal=Cell&doi=10.1016%2Fj.cell.2009.06.034&volume=138&pages=645-659&publication_year=2009&author=Gupta%2CPB&author=Onder%2CTT&author=Jiang%2CG&author=Tao%2CK&author=Kuperwasser%2CC&author=Weinberg%2CRA?
- https://doi.org/10.1016%2Fj.cell.2010.04.020's total income per month
- How much money does http://scholar.google.com/scholar_lookup?&title=A%20temporarily%20distinct%20subpopulation%20of%20slow-cycling%20melanoma%20cells%20is%20required%20for%20continuous%20tumor%20growth&journal=Cell&doi=10.1016%2Fj.cell.2010.04.020&volume=141&pages=583-594&publication_year=2010&author=Roesch%2CA&author=Fukunaga-Kalabis%2CM&author=Schmidt%2CEC&author=Zabierowski%2CSE&author=Brafford%2CPA&author=Vultur%2CA make?
- How much does https://doi.org/10.1038%2Fnm0909-1010 rake in every month?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Cancer%20stem%20cells%3A%20mirage%20or%20reality%3F&journal=Nat%20Med&doi=10.1038%2Fnm0909-1010&volume=15&pages=1010-1012&publication_year=2009&author=Gupta%2CPB&author=Chaffer%2CCL&author=Weinberg%2CRA?
- How much revenue does https://doi.org/10.1016%2Fj.cell.2008.03.027 produce monthly?
- See how much http://scholar.google.com/scholar_lookup?&title=The%20epithelial-mesenchymal%20transition%20generates%20cells%20with%20properties%20of%20stem%20cells&journal=Cell&doi=10.1016%2Fj.cell.2008.03.027&volume=133&pages=704-715&publication_year=2008&author=Mani%2CSA&author=Guo%2CW&author=Liao%2CMJ&author=Eaton%2CEN&author=Ayyanan%2CA&author=Zhou%2CAY makes per month
- How much does https://doi.org/10.1073%2Fpnas.1006732107 make?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Cancer%20stem%20cells%20from%20human%20breast%20tumors%20are%20involved%20in%20spontaneous%20metastases%20in%20orthotopic%20mouse%20models&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.1006732107&volume=107&pages=18115-18120&publication_year=2010&author=Liu%2CH&author=Patel%2CMR&author=Prescher%2CJA&author=Patsialou%2CA&author=Qian%2CD&author=Lin%2CJ each month?
- How much money does https://doi.org/10.1158%2F0008-5472.CAN-05-3153 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Cancer%20stem%20cells%3A%20an%20old%20idea--a%20paradigm%20shift&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-05-3153&volume=66&pages=1883-1890&publication_year=2006&author=Wicha%2CMS&author=Liu%2CS&author=Dontu%2CG earn?
- Get to know https://doi.org/10.3346%2Fjkms.2007.22.5.898's earnings
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Transforming%20growth%20factor%20beta1%20induces%20epithelial-to-mesenchymal%20transition%20of%20A549%20cells&journal=J%20Korean%20Med%20Sci&doi=10.3346%2Fjkms.2007.22.5.898&volume=22&pages=898-904&publication_year=2007&author=Kim%2CJH&author=Jang%2CYS&author=Eom%2CKS&author=Hwang%2CYI&author=Kang%2CHR&author=Jang%2CSH produce monthly?
- https://doi.org/10.1016%2Fj.lungcan.2008.05.017's revenue stream
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Epithelial%20to%20mesenchymal%20transition%20derived%20from%20repeated%20exposure%20to%20gefitinib%20determines%20the%20sensitivity%20to%20EGFR%20inhibitors%20in%20A549%2C%20a%20non-small%20cell%20lung%20cancer%20cell%20line&journal=Lung%20Cancer&doi=10.1016%2Fj.lungcan.2008.05.017&volume=63&pages=219-226&publication_year=2009&author=Rho%2CJK&author=Choi%2CYJ&author=Lee%2CJK&author=Ryoo%2CBY&author=Na%2CII&author=Yang%2CSH bring in?
- What's the monthly money flow for https://doi.org/10.1158%2F0008-5472.CAN-07-2545?
- How much does http://scholar.google.com/scholar_lookup?&title=ABCG2%20expression%20and%20side%20population%20abundance%20regulated%20by%20a%20transforming%20growth%20factor%20beta-directed%20epithelial-mesenchymal%20transition&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-07-2545&volume=68&pages=800-807&publication_year=2008&author=Yin%2CL&author=Castagnino%2CP&author=Assoian%2CRK net monthly?
- How much does https://doi.org/10.1158%2F1078-0432.CCR-07-6735 generate monthly?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Snail%20up-regulates%20proinflammatory%20mediators%20and%20inhibits%20differentiation%20in%20oral%20keratinocytes&journal=Cancer%20Res&doi=10.1158%2F1078-0432.CCR-07-6735&volume=68&pages=4525-4530&publication_year=2008&author=Lyons%2CJG&author=Patel%2CV&author=Roue%2CNC&author=Fok%2CSY&author=Soon%2CLL&author=Halliday%2CGM
- How profitable is https://link.springer.com/doi/10.1007/s10585-010-9367-3?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=A%20systems%20view%20of%20epithelial-mesenchymal%20transition%20signaling%20states&journal=Clin%20Exp%20Metastasis&doi=10.1007%2Fs10585-010-9367-3&volume=28&pages=137-155&publication_year=2011&author=Thomson%2CS&author=Petti%2CF&author=Sujka-Kwok%2CI&author=Mercado%2CP&author=Bean%2CJ&author=Monaghan%2CM?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Cross-talk%20between%20TGF-beta1%20and%20IL-6%20in%20human%20trabecular%20meshwork%20cells&journal=Mol%20Vision&volume=15&pages=326-334&publication_year=2009&author=Liton%2CPB&author=Li%2CG&author=Luna%2CC&author=Gonzalez%2CP&author=Epstein%2CDL?
- How much cash flow does https://doi.org/10.1002%2F%28SICI%291096-9896%28199705%29182%3A1%3C76%3A%3AAID-PATH805%3E3.0.CO%3B2-B have monthly?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Interleukin%206%20gene-transfected%20mouse%20mammary%20adenocarcinoma%3A%20tumour%20cell%20growth%20and%20metastatic%20potential&journal=J%20Pathol&doi=10.1002%2F%28SICI%291096-9896%28199705%29182%3A1%3C76%3A%3AAID-PATH805%3E3.0.CO%3B2-B&volume=182&pages=76-85&publication_year=1997&author=Di%20Carlo%2CE&author=Modesti%2CA&author=Castrilli%2CG&author=Landuzzi%2CL&author=Allione%2CA&author=de%20Giovanni%2CC is on a monthly basis
- How much does https://doi.org/10.1038%2Fnature09161 rake in every month?
- How much money does http://scholar.google.com/scholar_lookup?&title=Human%20melanoma-initiating%20cells%20express%20neural%20crest%20nerve%20growth%20factor%20receptor%20CD271&journal=Nature&doi=10.1038%2Fnature09161&volume=466&pages=133-137&publication_year=2010&author=Boiko%2CAD&author=Razorenova%2COV&author=van%20de%20Rijn%2CM&author=Swetter%2CSM&author=Johnson%2CDL&author=Ly%2CDP make?
- What are the earnings of https://doi.org/10.1038%2F466040a?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Cancer%20stem%20cells%3A%20invitation%20to%20a%20second%20round&journal=Nature&doi=10.1038%2F466040a&volume=466&pages=40-41&publication_year=2010&author=Dirks%2CP bring in?
- How profitable is https://doi.org/10.1073%2Fpnas.1018898108?
- How much money does http://scholar.google.com/scholar_lookup?&title=Inducible%20formation%20of%20breast%20cancer%20stem%20cells%20and%20their%20dynamic%20equilibrium%20with%20non-stem%20cancer%20cells%20via%20IL6%20secretion&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.1018898108&volume=108&pages=1397-1402&publication_year=2011&author=Iliopoulos%2CD&author=Hirsch%2CHA&author=Wang%2CG&author=Struhl%2CK generate?
- What's https://doi.org/10.1016%2Fj.cell.2011.07.026's gross income?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Stochastic%20state%20transitions%20give%20rise%20to%20phenotypic%20equilibrium%20in%20populations%20of%20cancer%20cells&journal=Cell&doi=10.1016%2Fj.cell.2011.07.026&volume=146&pages=633-644&publication_year=2011&author=Gupta%2CPB&author=Fillmore%2CCM&author=Jiang%2CG&author=Shapira%2CSD&author=Tao%2CK&author=Kuperwasser%2CC making per month?
- What's the profit of https://doi.org/10.1158%2F0008-5472.CAN-10-2638?
- How much does http://scholar.google.com/scholar_lookup?&title=Coexpression%20of%20Oct4%20and%20Nanog%20enhances%20malignancy%20in%20lung%20adenocarcinoma%20by%20inducing%20cancer%20stem%20cell-like%20properties%20and%20epithelial-mesenchymal%20transdifferentiation&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-10-2638&volume=70&pages=10433-10444&publication_year=2010&author=Chiou%2CSH&author=Wang%2CML&author=Chou%2CYT&author=Chen%2CCJ&author=Hong%2CCF&author=Hsieh%2CWJ bring in each month?
- https://doi.org/10.1073%2Fpnas.1009472107 income
- Financial intake of http://scholar.google.com/scholar_lookup?&title=TGF-beta%20IL-6%20axis%20mediates%20selective%20and%20adaptive%20mechanisms%20of%20resistance%20to%20molecular%20targeted%20therapy%20in%20lung%20cancer&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.1009472107&volume=107&pages=15535-15540&publication_year=2010&author=Yao%2CZ&author=Fenoglio%2CS&author=Gao%2CDC&author=Camiolo%2CM&author=Stiles%2CB&author=Lindsted%2CT
- How much cash flow does https://doi.org/10.1111%2Fj.1742-4658.2009.07031.x have monthly?
- What's http://scholar.google.com/scholar_lookup?&title=Control%20of%20transforming%20growth%20factor%20beta%20signal%20transduction%20by%20small%20GTPases&journal=FEBS%20J&doi=10.1111%2Fj.1742-4658.2009.07031.x&volume=276&pages=2947-2965&publication_year=2009&author=Kardassis%2CD&author=Murphy%2CC&author=Fotsis%2CT&author=Moustakas%2CA&author=Stournaras%2CC's gross income?
- Find out how much https://doi.org/10.1038%2Fnature03688 earns monthly
- How much does http://scholar.google.com/scholar_lookup?&title=Rac1b%20and%20reactive%20oxygen%20species%20mediate%20MMP-3-induced%20EMT%20and%20genomic%20instability&journal=Nature&doi=10.1038%2Fnature03688&volume=436&pages=123-127&publication_year=2005&author=Radisky%2CDC&author=Levy%2CDD&author=Littlepage%2CLE&author=Liu%2CH&author=Nelson%2CCM&author=Fata%2CJE rake in every month?
- How much does https://doi.org/10.1016%2Fj.febslet.2010.03.042 earn?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Rac1%20modulates%20TGF-beta1-mediated%20epithelial%20cell%20plasticity%20and%20MMP9%20production%20in%20transformed%20keratinocytes&journal=FEBS%20Lett&doi=10.1016%2Fj.febslet.2010.03.042&volume=584&pages=2305-2310&publication_year=2010&author=Santibanez%2CJF&author=Kocic%2CJ&author=Fabra%2CA&author=Cano%2CA&author=Quintanilla%2CM?
- What's the profit of https://doi.org/10.1084%2Fjem.183.4.1797?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Isolation%20and%20functional%20properties%20of%20murine%20hematopoietic%20stem%20cells%20that%20are%20replicating%20in%20vivo&journal=J%20Exp%20Med&doi=10.1084%2Fjem.183.4.1797&volume=183&pages=1797-1806&publication_year=1996&author=Goodell%2CMA&author=Brose%2CK&author=Paradis%2CG&author=Conner%2CAS&author=Mulligan%2CRC?
- Explore the financials of https://doi.org/10.1074%2Fjbc.M300341200
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=p19Arf-p53%20tumor%20suppressor%20pathway%20regulates%20cell%20motility%20by%20suppression%20of%20phosphoinositide%203-kinase%20and%20Rac1%20GTPase%20activities&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M300341200&volume=278&pages=14414-14419&publication_year=2003&author=Guo%2CF&author=Gao%2CY&author=Wang%2CL&author=Zheng%2CY?
- Check the income stats for https://citation-needed.springer.com/v2/references/10.1038/cddis.2012.93?format=refman&flavour=references
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=S%20Akunuru
- Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22S%20Akunuru%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Q%20James%20Zhai?
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Q%20James%20Zhai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Zheng
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Financial intake of https://static-content.springer.com/esm/art%3A10.1038%2Fcddis.2012.93/MediaObjects/41419_2012_BFcddis201293_MOESM65_ESM.pdf
- How much does https://s100.copyright.com/AppDispatchServlet?title=Non-small%20cell%20lung%20cancer%20stem%2Fprogenitor%20cells%20are%20enriched%20in%20multiple%20distinct%20phenotypic%20subpopulations%20and%20exhibit%20plasticity&author=S%20Akunuru%20et%20al&contentID=10.1038%2Fcddis.2012.93©right=The%20Author%28s%29&publication=2041-4889&publicationDate=2012-07-19&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY-NC-ND generate monthly?
- How much does https://citation-needed.springer.com/v2/references/10.1038/cddis.2012.93?format=refman&flavour=citation gross monthly?
- See how much https://doi.org/10.1186/s12885-020-06818-0 makes per month
- What's the monthly income of https://doi.org/10.1007/s12015-020-10031-8?
- How profitable is https://doi.org/10.1186/s12957-016-1094-z?
- How much revenue does https://doi.org/10.1038/s41598-017-04756-9 produce monthly?
- How much does https://doi.org/10.1007/s00428-016-2057-z net monthly?
- How profitable is https://www.protocols.io/?
- See how much https://www.natureindex.com/ makes per month
- How much money does http://www.naturechina.com make?
- How much does https://www.natureasia.com/ja-jp pull in?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref