
DOI . ORG {
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Title[redir]:
Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review | Molecular Biology Reports
Description:
The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3β² untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases. Further studies on Pum would be interesting and important to understand their evolutionarily conserved and divergent features across species, which can have potential implications in medicine, plant sciences as well as basic molecular and cell biological studies. A large number of research reports exists, pertaining to various aspects of Pum, in individual experimental systems. This review is a comprehensive summary of the functions, types, mechanism of action as well as the regulation of Pum in various species. Also, the research questions to be addressed in future are discussed.
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Keywords {π}
pubmed, article, google, scholar, cas, pumilio, central, cell, protein, puf, proteins, rna, regulation, biol, rnabinding, binding, pum, development, mrna, gene, drosophila, family, dev, mol, kim, plant, arabidopsis, translational, stem, human, regulates, required, sci, expression, chen, nanos, lin, apum, molecular, conserved, httpsdoiorg, zhang, wickens, wang, translation, genes, cells, res, identification, httpsdoiorgs,
Topics {βοΈ}
perk/eif2/atf4 signaling pathway month download article/chapter conserved rna-binding protein rna-binding proteins puf-5 rna-binding proteins distinguish pumilio rna-binding proteins post-transcriptional regulation distinct rna-binding modules rnai-mediated screen identifies triple-negative breast tumors pumilio2-deficient mice show human pumilio-homology domain mef2-mediated transcription translation factor eif-4e rna-binding proteins faithful pre-rrna processing /puf family proteins regulates sexual fates binding protein pab1p full article pdf puf-rna binding pre-ribosomal rna processing elegans puf protein pumilio-2 regulates translation noncoding rna norad pumilio homology domain research reports exists controls postsynaptic accumulation weidmann ca 3β² utr-mediated repression related subjects cap-dependent translation van etten jl mammalian pumilio family pumilio protein expression nucleolar apum23 protein human pumilio proteins sequestering pumilio proteins peptide binding motifs protein phosphatase 2c stem cell maintenance aba signaling pathway privacy choices/manage cookies drosophila pumilio protein ccr93 deadenylase acts pumilio-dependent control prevents premature cleavage norad deficient mice houshmandi ss pumilio directs deadenylation
Questions {β}
- Spassov D, Jurecic R (2003) The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function?
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headline:Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review
description:The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3β² untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases. Further studies on Pum would be interesting and important to understand their evolutionarily conserved and divergent features across species, which can have potential implications in medicine, plant sciences as well as basic molecular and cell biological studies. A large number of research reports exists, pertaining to various aspects of Pum, in individual experimental systems. This review is a comprehensive summary of the functions, types, mechanism of action as well as the regulation of Pum in various species. Also, the research questions to be addressed in future are discussed.
datePublished:2019-10-23T00:00:00Z
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Puf family
RNA binding proteins
Post-transcriptional gene regulation
3β²UTR
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headline:Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review
description:The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3β² untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases. Further studies on Pum would be interesting and important to understand their evolutionarily conserved and divergent features across species, which can have potential implications in medicine, plant sciences as well as basic molecular and cell biological studies. A large number of research reports exists, pertaining to various aspects of Pum, in individual experimental systems. This review is a comprehensive summary of the functions, types, mechanism of action as well as the regulation of Pum in various species. Also, the research questions to be addressed in future are discussed.
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