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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC98971/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC98971/. The analysis below is for the second page.

Title[redir]:
Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis - PMC
Description:
Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for the cleavage of most replication-dependent histone transcripts and the ...

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Education
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Fitness & Wellness

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Custom-built

No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.

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What is the average monthly size of ncbi.nlm.nih.gov audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 6,399,052 visitors per month in the current month.

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How Does Ncbi.nlm.nih.gov Make Money? {💸}

We don’t know how the website earns money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Ncbi.nlm.nih.gov might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

doi, google, scholar, pubmed, polya, polyadenylation, rna, site, pmc, free, article, cell, mrna, yeast, cleavage, processing, biol, protein, end, factors, mol, splicing, factor, genes, sequence, cpsf, gene, transcription, proteins, pap, mcb, complex, formation, sites, polymerase, binding, histone, exon, downstream, cells, element, termination, vitro, nuclear, premrna, signal, cstf, sequences, upstream, transcripts,

Topics {✒️}

peptidylprolyl-cis/trans-isomerase gene lead calcitonin/calcitonin gene-related peptide peptidylprolyl-cis/trans-isomerase b-cell stage-specific manner replication-dependent histone pre-mrna calcitonin gene-related peptide rrm-type rna-binding domains human beta-globin mrna pmc beta search human β-globin gene uv-induced rna cross-linking calcitonin/cgrp intronic enhancer dsx pre-mrna requires sequence-specific rna-binding protein calcitonin/cgrp pre-mrna calcitonin/cgrp-1 pre-mrna calcitonin-specific processing requires yeast pre-mrna-splicing protein double-stranded rna produced beta-tropomyosin pre-mrna carboxyl-terminal rna-binding site β-globin pre-mrnas amino-terminal rnp-type rbd snrnp-free u1a complex u1a snrnp-free complex hmt1-catalyzed arginine methylation epstein-barr virus wild-type precleaved rna human d-type cyclin calcitonin/cgrp polyadenylation enhancer rat7-1 temperature-sensitive allele sv40 late pre-mrna carboxyl-terminal primer-binding site polypyrimidine tract-binding protein polypyrimidine tract-binding protein polypyrimidine-tract-binding protein ccch zinc-binding motif tubulin polycistronic pre-mrna nonsense-mediated decay pathway mouse histone pre-mrna c-src alternative exon uridylate-rich downstream elements predominant full-length species cleavage-competent complex requires histone 3′-terminal stem-loop stem-loop binding protein pro-gly-rich region polymerase requires p34cdc2/cyclin histone pre-mrna processing u4/u6-specific 60kd

Questions {❓}

Alternative poly(A) site selection in complex transcription units: means to an end?
Are vertebrate exons scanned during splice-site selection?
Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?
For example, PAP is the obvious catalytic subunit for polyadenylation, but what is the catalytic subunit for cleavage?
Have some of the essential yeast proteins assumed auxiliary roles that have yet to be identified in the mammalian process?
How important is it to balance the levels of these factors in the cell?
How many different ways will the cell have devised to accomplish this alternative processing?
How, then, is transcription termination coupled to pre-mRNA processing?
If the strength of exon 4 recognition in calcitonin-producing cells is a composite of how well the different exonic and intronic elements are recognized, how is the cellular environment regulated to exclude exon 4 in neuronal cells?
Nuclear targeting sequences—a consensus?
Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog?
SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?
Transcription termination between the closely linked human complement genes C2 and factor B: common termination factor C2 and c-myc?
When the base pairing of U1 snRNA upstream of a poly(A) site is not strong, as in the examples described by Wassarman and Steitz (482), would a similar interaction of PAP and U1 70K contribute to the recognition of 3′-terminal exons?
SnRNP mediators of 3′ end processing: functional fossils?

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