
DOI . ORG {
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Title[redir]:
Chromosome instability and aneuploidy in the mammalian brain | Chromosome Research
Description:
This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the normal diploid set. It can manifest as either a deficiency or excess of chromosomes. CIN encompasses a broader range of chromosomal alterations, including aneuploidy as well as structural modifications in DNA. We provide an overview of the state-of-the-art methodologies utilized for studying aneuploidy and CIN in non-tumor somatic tissues devoid of clonally expanded populations of aneuploid cells. CIN and aneuploidy, well-established hallmarks of cancer cells, are also associated with the aging process. In non-transformed cells, aneuploidy can contribute to functional impairment and developmental disorders. Despite the importance of understanding the prevalence and specific consequences of aneuploidy and CIN in the aging brain, these aspects remain incompletely understood, emphasizing the need for further scientific investigations. This comprehensive review consolidates the present understanding, addresses discrepancies in the literature, and provides valuable insights for future research efforts.
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pubmed, article, google, scholar, cas, central, aneuploidy, cell, brain, chromosome, instability, human, aging, cells, cancer, vijg, chromosomal, somatic, montagna, dna, nat, httpsdoiorgs, genome, disease, sci, sequencing, nature, van, singlecell, usa, genet, mol, neurons, biol, variation, neurosci, number, genomic, rep, rev, chun, content, analysis, dev, copy, yang, zhang, normal, aneuploid, alzheimers,
Topics {โ๏ธ}
single-cell copy-number variations gene copy-number alterations month download article/chapter low-abundance somatic mutations bueno-de-mesquita hb somatic dna-repair capacities 1093/hmg/dds375 faggioli van den bos full article pdf aneuploidy-driven full senescence andriani ga advanced molecular cytogenetics low-level chromosomal aneuploidy articleย numberย 32 spatial multi-omics short-term molecular consequences nuclear genomic instability chromosome mis-segregation chromosome instability access genome sequencing reveals somatic mutation copy number detecting chromosome instability tumor cell populations chromosomal alterations measure chromosome instability high-throughput sequencing single-cell sequencing genomic mosaicism formed privacy choices/manage cookies single-cell omics somatic variant calling low-level mosaicism quispe-tintaya hoffman bolton ja detectable clonal mosaicism neurodegeneration ben-david van den engh low-level aneuploidy de groen pc article albert future research efforts numerical chromosomal variation central role van den berg den dunnen wf progeroid syndrome reveals tp53 mutation adult cerebellar cortex
Questions {โ}
- Vijg J, Dong X, Milholland B, Zhang L (2017) Genome instability: a conserved mechanism of ageing?
- Vijg J, Montagna C (2017) Genome instability and aging: cause or effect?
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