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We began analyzing https://link.springer.com/article/10.1007/s10577-023-09740-w, but it redirected us to https://link.springer.com/article/10.1007/s10577-023-09740-w. The analysis below is for the second page.

Title[redir]:
Chromosome instability and aneuploidy in the mammalian brain | Chromosome Research
Description:
This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the normal diploid set. It can manifest as either a deficiency or excess of chromosomes. CIN encompasses a broader range of chromosomal alterations, including aneuploidy as well as structural modifications in DNA. We provide an overview of the state-of-the-art methodologies utilized for studying aneuploidy and CIN in non-tumor somatic tissues devoid of clonally expanded populations of aneuploid cells. CIN and aneuploidy, well-established hallmarks of cancer cells, are also associated with the aging process. In non-transformed cells, aneuploidy can contribute to functional impairment and developmental disorders. Despite the importance of understanding the prevalence and specific consequences of aneuploidy and CIN in the aging brain, these aspects remain incompletely understood, emphasizing the need for further scientific investigations. This comprehensive review consolidates the present understanding, addresses discrepancies in the literature, and provides valuable insights for future research efforts.

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  • Education
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Custom-built

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๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {๐Ÿ”}

pubmed, article, google, scholar, cas, central, aneuploidy, cell, brain, chromosome, instability, human, aging, cells, cancer, vijg, chromosomal, somatic, montagna, dna, nat, httpsdoiorgs, genome, disease, sci, sequencing, nature, van, singlecell, usa, genet, mol, neurons, biol, variation, neurosci, number, genomic, rep, rev, chun, content, analysis, dev, copy, yang, zhang, normal, aneuploid, alzheimers,

Topics {โœ’๏ธ}

single-cell copy-number variations gene copy-number alterations month download article/chapter low-abundance somatic mutations bueno-de-mesquita hb somatic dna-repair capacities 1093/hmg/dds375 faggioli van den bos full article pdf aneuploidy-driven full senescence andriani ga advanced molecular cytogenetics low-level chromosomal aneuploidy articleย numberย 32 spatial multi-omics short-term molecular consequences nuclear genomic instability chromosome mis-segregation chromosome instability access genome sequencing reveals somatic mutation copy number detecting chromosome instability tumor cell populations chromosomal alterations measure chromosome instability high-throughput sequencing single-cell sequencing genomic mosaicism formed privacy choices/manage cookies single-cell omics somatic variant calling low-level mosaicism quispe-tintaya hoffman bolton ja detectable clonal mosaicism neurodegeneration ben-david van den engh low-level aneuploidy de groen pc article albert future research efforts numerical chromosomal variation central role van den berg den dunnen wf progeroid syndrome reveals tp53 mutation adult cerebellar cortex

Questions {โ“}

  • Vijg J, Dong X, Milholland B, Zhang L (2017) Genome instability: a conserved mechanism of ageing?
  • Vijg J, Montagna C (2017) Genome instability and aging: cause or effect?

Schema {๐Ÿ—บ๏ธ}

WebPage:
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         headline:Chromosome instability and aneuploidy in the mammalian brain
         description:This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the normal diploid set. It can manifest as either a deficiency or excess of chromosomes. CIN encompasses a broader range of chromosomal alterations, including aneuploidy as well as structural modifications in DNA. We provide an overview of the state-of-the-art methodologies utilized for studying aneuploidy and CIN in non-tumor somatic tissues devoid of clonally expanded populations of aneuploid cells. CIN and aneuploidy, well-established hallmarks of cancer cells, are also associated with the aging process. In non-transformed cells, aneuploidy can contribute to functional impairment and developmental disorders. Despite the importance of understanding the prevalence and specific consequences of aneuploidy and CIN in the aging brain, these aspects remain incompletely understood, emphasizing the need for further scientific investigations. This comprehensive review consolidates the present understanding, addresses discrepancies in the literature, and provides valuable insights for future research efforts.
         datePublished:2023-11-01T00:00:00Z
         dateModified:2023-11-01T00:00:00Z
         pageStart:1
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         sameAs:https://doi.org/10.1007/s10577-023-09740-w
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            Cancer
            Tumor
            Glioblastoma
            Brain
            Neurons
            Astrocytes
            Aneuploidy
            Mutations
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            Mutation frequency
            Disease
            Neurodegeneration
            Cell Biology
            Human Genetics
            Animal Genetics and Genomics
            Plant Genetics and Genomics
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      headline:Chromosome instability and aneuploidy in the mammalian brain
      description:This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the normal diploid set. It can manifest as either a deficiency or excess of chromosomes. CIN encompasses a broader range of chromosomal alterations, including aneuploidy as well as structural modifications in DNA. We provide an overview of the state-of-the-art methodologies utilized for studying aneuploidy and CIN in non-tumor somatic tissues devoid of clonally expanded populations of aneuploid cells. CIN and aneuploidy, well-established hallmarks of cancer cells, are also associated with the aging process. In non-transformed cells, aneuploidy can contribute to functional impairment and developmental disorders. Despite the importance of understanding the prevalence and specific consequences of aneuploidy and CIN in the aging brain, these aspects remain incompletely understood, emphasizing the need for further scientific investigations. This comprehensive review consolidates the present understanding, addresses discrepancies in the literature, and provides valuable insights for future research efforts.
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         Genomic instability
         Chromosome instability
         Copy number alterations
         Mutation frequency
         Disease
         Neurodegeneration
         Cell Biology
         Human Genetics
         Animal Genetics and Genomics
         Plant Genetics and Genomics
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            name:Albert Einstein College of Medicine
            address:
               name:Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, New York, USA
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            type:Organization
      name:Cristina Montagna
      affiliation:
            name:Department of Genetics, Albert Einstein College of Medicine
            address:
               name:Department of Genetics, Albert Einstein College of Medicine, New York, USA
               type:PostalAddress
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            name:Rutgers Cancer Institute of New Jersey
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      name:Department of Pathology, Yale School of Medicine, New Haven, USA
      name:Department of Genetics, Albert Einstein College of Medicine, New York, USA
      name:Departments of Obstetrics and Gynecology, and Genetics and Development, Columbia University, New York, USA
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