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Keywords {🔍}

cells, cell, pubmed, data, cnvs, article, cnv, neurons, brain, google, scholar, number, control, read, fig, disease, dataset, central, coverage, cas, alzheimers, reads, cortex, lcm, datasets, found, van, copy, bos, variation, somatic, published, scwgs, events, study, additional, regions, file, sequencing, facs, individuals, human, ginkgo, patients, counts, analysis, controls, hippocampal, higher, lcmisolated,

Topics {✒️}

= estimated\_state_{cnv}\\ &\qquad\quad\qquad fluorescence-activated cell sorting gov/pmc/articles/pmc3233860/ ewels zeliha gözde turan cell-type-specific nuclei sorting laser capture microdissection laser capture microdissection single-cell copy-number variations article download pdf somatic copy-number variations çağdaş devrim son open access publishing genome-wide copy number paul-flechsig-institute x-axes illustrate pc1 sabrina leclere-turbant ]/ sd_{cnv}\\&\qquad\text{ pca-based denoising approach y-axes show pc2 tübi̇tak grant 215z495 pca-based denoising method central nervous system sided rank-sum test copy-number estimation method average post-mortem delays x-axes show chromosomes wilcoxon rank-sum test article turan ethnicity-specific rare variants demented age-matched controls ginkgo-estimated copy number yurov yb single-cell dna sequencing cell-type-specific nuclei lcm-isolated uncorrected-filtered data single-cell cancer genomics accession numbers e-mtab-4184 healthy age-matched controls applying pca-based correction principal component analysis pca-based denoising linear mixed-effects model van den bos higher read-depth variability represent false positives estimated cnv-carrying neurons privacy choices/manage cookies remove experimentally-induced variation single cell-specific cnvs $$ z_{1}{\text{-score}} =

Questions {❓}

• Arendt T, Stieler J, Ueberham U (2017) Is sporadic Alzheimer’s disease a developmental disorder?
• Mrdenovic D, Pieta IS, Nowakowski R, Kutner W, Lipkowski J, Pieta P (2022) Amyloid β interaction with model cell membranes—what are the toxicity-defining properties of amyloid β?

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         headline:Somatic copy number variant load in neurons of healthy controls and Alzheimer’s disease patients
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PostalAddress:
      name:Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
      name:Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany
      name:Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany
      name:Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
      name:Usher Institute, The University of Edinburgh, Edinburgh, UK
      name:Department of Biology, Lund University, Lund, Sweden
      name:Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
      name:Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany
      name:Laboratoire de Neuropathologie Escourolle, Hôpital de La Salpêtrière, Paris, France
      name:Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
      name:Laboratoire de Neuropathologie Escourolle, Hôpital de La Salpêtrière, Paris, France
      name:Department of Bioinformatics, Hacettepe University, Ankara, Turkey
      name:Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany
      name:Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
      name:Paul Flechsig Institute for Brain Research, Leipzig University, Leipzig, Germany

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