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We began analyzing https://link.springer.com/article/10.1007/s00401-006-0127-z, but it redirected us to https://link.springer.com/article/10.1007/s00401-006-0127-z. The analysis below is for the second page.

Title[redir]:
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry | Acta Neuropathologica
Description:
Assessment of Alzheimer’s disease (AD)-related neurofibrillary pathology requires a procedure that permits a sufficient differentiation between initial, intermediate, and late stages. The gradual deposition of a hyperphosphorylated tau protein within select neuronal types in specific nuclei or areas is central to the disease process. The staging of AD-related neurofibrillary pathology originally described in 1991 was performed on unconventionally thick sections (100 μm) using a modern silver technique and reflected the progress of the disease process based chiefly on the topographic expansion of the lesions. To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections (5–15 μm) and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis. It is anticipated that this revised methodological protocol will enable a more uniform application of the staging procedure.

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Keywords {🔍}

google, scholar, disease, sections, cas, article, neurofibrillary, alzheimers, braak, pubmed, stage, pathology, region, staging, lesions, fig, neocortex, temporal, entorhinal, stages, tau, transentorhinal, areas, aging, gyrus, material, atir, neurobiol, silver, area, tissue, diagnosis, tangles, layer, neuropathol, alzheimer, brain, procedure, figs, hyperphosphorylated, occipital, block, cells, acta, paraffin, protein, technique, neuropathological, striate, cortical,

Topics {✒️}

article download pdf serin-proline motifs upstream van hoesen gw require special pre-treatments european commission lshm-ct-2004-503039 close-meshed prevalence rates at8-ir nerve cells intermeshing at8-ir neurites at8-ir pyramidal cells at8-immunoreactions permit counter-staining extensive protein cross-linking at8-immunoreactive nerve cells wedge-shaped lamina dissecans at8-ir plexus fills at8-ir projection neurons at8-ir granule cells isolated at8-ir neurons adjoining occipito-temporal gyri occipito-temporal gyrus laterally adjoining occipito-temporal gyrus polyethylene glycol embedding at8-ir neurites form at8-ir sections showing silver-iodate technique proposed ad-related neurofibrillary pathology alzheimer-related τ-pathology ad-related neurofibrillary lesions thick silver-stained sections layers ii-iiiab blurs privacy choices/manage cookies at8-immunoreactive plexuses located van de voorde entorhinal layers pre-α related subjects neocortical association areas radially oriented neurites sharply drawn upper german research council at8-ir neurites shows varying degrees de-ionized water paired helical filaments goethe university clinic at8-ir intraneuronal outer layers ii–iv monoclonal antibody at8 at8-immunostained thick uninvolved layers iiic unconventionally thick sections hitherto uninvolved areas

Questions {❓}

Bancher C, Paulus W, Paukner K, Jellinger K (1997) Neuropathologic diagnosis of Alzheimer’s disease: consensus between practicing neuropathologists?
Duyckaerts C, Bennecib M, Grignon Y, Piette F, Hauw JJ (1996) Is the topography of Alzheimer’s disease lesions a clue to their pathogenesis?
Duyckaerts C, Hauw JJ (1997b) Prevalence, incidence and duration of Braak’s stages in the general population: can we know?

Schema {🗺️}

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