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Title:
Practical measures to simplify the Braak tangle staging method for routine pathological screening | Acta Neuropathologica
Description:
The examination of neurofibrillary tangles is now recommended for the diagnosis of Alzheimer’s disease as their location and density can distinguish early, intermediate and late disease stages. While the Braak tangle staging protocol can identify these stages, it uses an uncommon silver stain and hippocampal sample. The present study evaluates the Braak protocol using commonly used methods and cases fulfilling either CERAD criteria for Alzheimer’s disease, criteria for dementia with Lewy bodies or without neurological disease. Temporal and occipital cortices from 72 cases were stained using tau immunohistochemistry and the Gallyas and modified Bielschowsky silver stains. The modified Bielschowsky silver stain was equivalent to the Gallyas silver stain for tangle staging. Semiquantitative evaluation of neurofibrillary tangles in the hippocampus and the inferior temporal cortex provided equivalent information to that obtained using the original Braak tangle staging protocol (kappa statistic of 0.97). Comparison of this modification with the CERAD criteria provided moderate agreement (0.51) between diagnostic categories when cases with dementia with Lewy bodies were included, but substantially increased agreement (0.74) when they were excluded. This simplification of the Braak tangle staging protocol is easy to apply, can be readily incorporated into existing CERAD procedures, and helps to distinguish cases with neurofibrillary tangles from those with Lewy bodies.
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article, braak, tangle, staging, disease, access, privacy, cookies, content, information, research, neurofibrillary, alzheimers, publish, search, tangles, protocol, silver, cases, open, data, log, journal, acta, measures, harding, kril, halliday, stages, stain, cerad, criteria, dementia, lewy, bodies, discover, springer, optional, personal, parties, policy, find, track, neuropathologica, practical, simplify, method, routine, pathological, screening,
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month download article/chapter multiple aβ-derived measures routine pathological screening related subjects cortical cell damage full article pdf privacy choices/manage cookies late disease stages practical measures substantially increased agreement machine learning uncommon silver stain existing cerad procedures tangle staging european economic area present study evaluates predict cognitive status reduced cortical ptau gallyas silver stain conditions privacy policy tau immunohistochemistry diagnostic categories check access instant access accepting optional cookies braak protocol australia e-mail neurofibrillary tangles improve dementia assessment journal finder publish article log acta neuropathol 99 article harding article cite cerad criteria neurological disease markers disease pathology privacy policy personal data books a research optional cookies manage preferences aβ deposition subscription content similar content au antony data protection essential cookies
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headline:Practical measures to simplify the Braak tangle staging method for routine pathological screening
description: The examination of neurofibrillary tangles is now recommended for the diagnosis of Alzheimer’s disease as their location and density can distinguish early, intermediate and late disease stages. While the Braak tangle staging protocol can identify these stages, it uses an uncommon silver stain and hippocampal sample. The present study evaluates the Braak protocol using commonly used methods and cases fulfilling either CERAD criteria for Alzheimer’s disease, criteria for dementia with Lewy bodies or without neurological disease. Temporal and occipital cortices from 72 cases were stained using tau immunohistochemistry and the Gallyas and modified Bielschowsky silver stains. The modified Bielschowsky silver stain was equivalent to the Gallyas silver stain for tangle staging. Semiquantitative evaluation of neurofibrillary tangles in the hippocampus and the inferior temporal cortex provided equivalent information to that obtained using the original Braak tangle staging protocol (kappa statistic of 0.97). Comparison of this modification with the CERAD criteria provided moderate agreement (0.51) between diagnostic categories when cases with dementia with Lewy bodies were included, but substantially increased agreement (0.74) when they were excluded. This simplification of the Braak tangle staging protocol is easy to apply, can be readily incorporated into existing CERAD procedures, and helps to distinguish cases with neurofibrillary tangles from those with Lewy bodies.
datePublished:
dateModified:
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sameAs:https://doi.org/10.1007/PL00007425
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Key words Alzheimer’s disease
Diagnosis
Entorhinal cortex
Hippocampus
Neurofibrillary tangles
Pathology
Neurosciences
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headline:Practical measures to simplify the Braak tangle staging method for routine pathological screening
description: The examination of neurofibrillary tangles is now recommended for the diagnosis of Alzheimer’s disease as their location and density can distinguish early, intermediate and late disease stages. While the Braak tangle staging protocol can identify these stages, it uses an uncommon silver stain and hippocampal sample. The present study evaluates the Braak protocol using commonly used methods and cases fulfilling either CERAD criteria for Alzheimer’s disease, criteria for dementia with Lewy bodies or without neurological disease. Temporal and occipital cortices from 72 cases were stained using tau immunohistochemistry and the Gallyas and modified Bielschowsky silver stains. The modified Bielschowsky silver stain was equivalent to the Gallyas silver stain for tangle staging. Semiquantitative evaluation of neurofibrillary tangles in the hippocampus and the inferior temporal cortex provided equivalent information to that obtained using the original Braak tangle staging protocol (kappa statistic of 0.97). Comparison of this modification with the CERAD criteria provided moderate agreement (0.51) between diagnostic categories when cases with dementia with Lewy bodies were included, but substantially increased agreement (0.74) when they were excluded. This simplification of the Braak tangle staging protocol is easy to apply, can be readily incorporated into existing CERAD procedures, and helps to distinguish cases with neurofibrillary tangles from those with Lewy bodies.
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dateModified:
pageStart:199
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Diagnosis
Entorhinal cortex
Hippocampus
Neurofibrillary tangles
Pathology
Neurosciences
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