We are analyzing https://link.springer.com/article/10.1007/bf00227819.

Title:
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes | Acta Neuropathologica
Description:
Acta Neuropathologica - A modified form of the microtubule-associated protein Tau is the major component of the paired helical filaments (PHF) found in Alzheimer
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Keywords {🔍}

tau, google, scholar, antibodies, alzheimers, disease, alzheimer, paired, helical, proteins, article, protein, monoclonal, epitopes, filaments, usa, sci, mercken, proc, natl, acad, marc, vandermeeren, human, research, lübke, jan, gheuens, microtubuleassociated, normal, access, brain, privacy, cookies, content, acta, boons, van, neurofibrillary, nature, pubmed, publish, search, specificity, voorde, binder, tangles, phosphorylation, cas, lee,

Topics {✒️}

month download article/chapter sufficient phf-tau-specific markers neurobiology born-bunge foundation high-affinity antibodies specific privacy choices/manage cookies janssen research foundation van de voorde paired helical filament mailman research center full article pdf specific monoclonal antibodies sandwich enzyme immunoassay born-bunge foundation monoclonal antibodies targeting paired helical filaments alkaline phosphatase treatment peripheral nervous system sensitive sandwich elisa monoclonal neurofilament antibodies phosphatase-sensitive epitopes normal human central european economic area c-terminal regions degenerating cortical neurons polyacrylamide gel electrophoresis avidin-biotinperoxidase complex electron microscopical study anti-neurofilament antibodies abnormally phosphorylated epitopes epitopes present conditions privacy policy posttranslational tau modifications human tau proteins human tau detection human brain tissue alzheimer pathological structures phosphorylated tau protein normal tau revealed accepting optional cookies article mercken individual neurofilament proteins martin jj normal tau proteins heat-stable microtubule alzheimer cytoskeletal pathology alzheimer brain cortices related subjects journal finder publish monoclonal antibodies monoclonal antibodies 423

Questions {❓}

Flament S, Delacourte A (1990) Tau marker?

Schema {🗺️}

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         headline:Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes
         description:A modified form of the microtubule-associated protein Tau is the major component of the paired helical filaments (PHF) found in Alzheimer's disease. The characterization of these posttranslational Tau modifications is hindered by the lack of sufficient PHF-Tau-specific markers. Here we describe several monoclonal antibodies, prepared by immunization with PHF, two of which showed a selective specificity for PHF-Tau without cross-reactivity with normal Tau. Epitope recognition by these two monoclonals was sensitive to alkaline phosphatase treatment. In Western blotting these monoclonal antibodies reacted specifically with the abnormally phosphorylated epitopes on Alzheimer's disease-associated PHF-Tau. One of the new antibodies can be used for the construction of a sandwich enzyme-linked immunosorbent assay for the specific detection of PHF-Tau without cross-reactivity to normal Tau proteins.
         datePublished:
         dateModified:
         pageStart:265
         pageEnd:272
         sameAs:https://doi.org/10.1007/BF00227819
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            Tau
            Phosphorylation
            Monoclonal antibodies
            Pathology
            Neurosciences
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      headline:Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes
      description:A modified form of the microtubule-associated protein Tau is the major component of the paired helical filaments (PHF) found in Alzheimer's disease. The characterization of these posttranslational Tau modifications is hindered by the lack of sufficient PHF-Tau-specific markers. Here we describe several monoclonal antibodies, prepared by immunization with PHF, two of which showed a selective specificity for PHF-Tau without cross-reactivity with normal Tau. Epitope recognition by these two monoclonals was sensitive to alkaline phosphatase treatment. In Western blotting these monoclonal antibodies reacted specifically with the abnormally phosphorylated epitopes on Alzheimer's disease-associated PHF-Tau. One of the new antibodies can be used for the construction of a sandwich enzyme-linked immunosorbent assay for the specific detection of PHF-Tau without cross-reactivity to normal Tau proteins.
      datePublished:
      dateModified:
      pageStart:265
      pageEnd:272
      sameAs:https://doi.org/10.1007/BF00227819
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         Alzheimer's disease
         Tau
         Phosphorylation
         Monoclonal antibodies
         Pathology
         Neurosciences
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