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We began analyzing https://link.springer.com/article/10.1007/s00394-008-0738-3, but it redirected us to https://link.springer.com/article/10.1007/s00394-008-0738-3. The analysis below is for the second page.

Title[redir]:
Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment | European Journal of Nutrition
Description:
Obesity has been associated with a chronic low degree inflammatory response, characterized by an increase of inflammatory adipocytokines like tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6) as well as the synthesis of acute phase reactants such as haptoglobin. To evaluate if impairments in the inflammatory response at the white adipose tissue (WAT) level could be involved in the mechanisms conferring susceptibility or resistance to high-fat diet-induced obesity (DIO). The expression levels of WAT genes and systemic markers related to inflammation were evaluated in two groups of rats fed with a high-fat diet during 15 days that showed either an early susceptibility (DIO) or resistance (DR) to develop obesity. We also tested the efficacy of the eicosapentaenoic (EPA) ω-3 fatty acid treatment (35 days) to potentially counteract the obesity-associated inflammatory features in DIO rats. This trial showed that high-fat diet induces an increase on mRNA levels on TNF-α and haptoglobin in DIO animals (P < 0.05), while no significant changes were observed on DR rats. Furthermore, a significant increase in IL-6 mRNA (P < 0.05) was found in both DR and DIO rats. EPA-treatment caused a significant decrease in IL-6 mRNA (P < 0.05), without significant changes in haptoglobin mRNA levels in adipose tissue. An unexpected decrease was observed in haptoglobin serum levels (P < 0.05) in DIO rats, which was reverted to control values in EPA-treated animals. Our data suggest that obesity susceptibility or resistance may depend on the genetic make up related to inflammatory features, and support a role for ω-3 fatty acids in the prevention of obesity-associated inflammation in adipose tissue. In addition, our data do not support the hypothesis that serum haptoglobin is an acute phase protein expected to be positively related to increased adiposity in rats, at least in early and medium stages of DIO.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

article, google, scholar, cas, adipose, obesity, tissue, inflammatory, rats, haptoglobin, resistance, expression, inflammation, insulin, fatty, dietinduced, morenoaliaga, necrosis, dio, levels, diabetes, physiol, content, highfat, acids, access, weight, clin, privacy, cookies, data, journal, epa, treatment, marti, related, obese, hotamisligil, metab, tumor, factoralpha, publish, search, nutrition, resistant, pérezecharri, pérezmatute, adipocytokines, study, susceptibility,

Topics {✒}

high-fat diet-induced obesity marĂ­a jesus moreno-aliaga high-fat diet induces tumor necrosis factor-alpha month download article/chapter high-fat-diet obesity f-dio obesity-prone rat tumour necrosis factor-alpha high-fat-fed rats tumoral necrosis factor-α high-fat diet population-based cohort study tumor necrosis factor inflammation-sensitive plasma proteins moreno-aliaga mj ω-3 fatty acids eicosapentaenoic acid actions obesity-linked insulin resistance article pĂ©rez-echarri diet-induced obesity patricia pĂ©rez-matute diets high article european journal obesity-related disease full article pdf rat adipose tissue privacy choices/manage cookies white adipose tissue gamma-linolenic acid human adipose tissue mechanisms conferring susceptibility gene expression profile hotamisligil gs obese diabetic mice systemic markers related european economic area acute phase reactants related subjects epa-treatment caused differential inflammatory status plasmacytoid dendritic cells dunn-meynell aa innate immune system body mass index nebe-von-caron ministerio de educaciĂłn expert technical assistance author information authors conditions privacy policy increased inflammatory properties

Questions {❓}

  • Moreno-Aliaga MJ, Santos JL, Marti A, Martinez JA (2005) Does weight loss prognosis depend on genetic make-up?

Schema {đŸ—ș}

WebPage:
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         headline:Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment
         description:Obesity has been associated with a chronic low degree inflammatory response, characterized by an increase of inflammatory adipocytokines like tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6) as well as the synthesis of acute phase reactants such as haptoglobin. To evaluate if impairments in the inflammatory response at the white adipose tissue (WAT) level could be involved in the mechanisms conferring susceptibility or resistance to high-fat diet-induced obesity (DIO). The expression levels of WAT genes and systemic markers related to inflammation were evaluated in two groups of rats fed with a high-fat diet during 15 days that showed either an early susceptibility (DIO) or resistance (DR) to develop obesity. We also tested the efficacy of the eicosapentaenoic (EPA) ω-3 fatty acid treatment (35 days) to potentially counteract the obesity-associated inflammatory features in DIO rats. This trial showed that high-fat diet induces an increase on mRNA levels on TNF-α and haptoglobin in DIO animals (P < 0.05), while no significant changes were observed on DR rats. Furthermore, a significant increase in IL-6 mRNA (P < 0.05) was found in both DR and DIO rats. EPA-treatment caused a significant decrease in IL-6 mRNA (P < 0.05), without significant changes in haptoglobin mRNA levels in adipose tissue. An unexpected decrease was observed in haptoglobin serum levels (P < 0.05) in DIO rats, which was reverted to control values in EPA-treated animals. Our data suggest that obesity susceptibility or resistance may depend on the genetic make up related to inflammatory features, and support a role for ω-3 fatty acids in the prevention of obesity-associated inflammation in adipose tissue. In addition, our data do not support the hypothesis that serum haptoglobin is an acute phase protein expected to be positively related to increased adiposity in rats, at least in early and medium stages of DIO.
         datePublished:2008-09-18T00:00:00Z
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      headline:Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment
      description:Obesity has been associated with a chronic low degree inflammatory response, characterized by an increase of inflammatory adipocytokines like tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6) as well as the synthesis of acute phase reactants such as haptoglobin. To evaluate if impairments in the inflammatory response at the white adipose tissue (WAT) level could be involved in the mechanisms conferring susceptibility or resistance to high-fat diet-induced obesity (DIO). The expression levels of WAT genes and systemic markers related to inflammation were evaluated in two groups of rats fed with a high-fat diet during 15 days that showed either an early susceptibility (DIO) or resistance (DR) to develop obesity. We also tested the efficacy of the eicosapentaenoic (EPA) ω-3 fatty acid treatment (35 days) to potentially counteract the obesity-associated inflammatory features in DIO rats. This trial showed that high-fat diet induces an increase on mRNA levels on TNF-α and haptoglobin in DIO animals (P < 0.05), while no significant changes were observed on DR rats. Furthermore, a significant increase in IL-6 mRNA (P < 0.05) was found in both DR and DIO rats. EPA-treatment caused a significant decrease in IL-6 mRNA (P < 0.05), without significant changes in haptoglobin mRNA levels in adipose tissue. An unexpected decrease was observed in haptoglobin serum levels (P < 0.05) in DIO rats, which was reverted to control values in EPA-treated animals. Our data suggest that obesity susceptibility or resistance may depend on the genetic make up related to inflammatory features, and support a role for ω-3 fatty acids in the prevention of obesity-associated inflammation in adipose tissue. In addition, our data do not support the hypothesis that serum haptoglobin is an acute phase protein expected to be positively related to increased adiposity in rats, at least in early and medium stages of DIO.
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         white adipose tissue (WAT)
         Nutrition
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