We are analyzing https://link.springer.com/article/10.1007/bf03167050.

Title:
Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity | Journal of Physiology and Biochemistry
Description:
The aim of the present study was to identify the role of leptin and adiponectin in the development of resistance or susceptibility to diet-induced obesity in rats. For this purpose, male Wistar rats were fed with standard laboratory diet (control group) or cafeteria diet. After 15 days, two groups of rats with different response respect to the cafeteria diet were identified, and were assigned as diet-induced obesity (DIO) and diet resistant (DR) rats. The high-fat diet induced a very dignificant increase in both body and fat mass weight in DIO group. However, DR rats, gained even less weight than control-fed animals. Food intake was increased in cafeteria-fed rats (both DIO and DR) in comparison to control group; but hyperphagia was higher in DIO rats. In addition, feed efficiency (the ratio of weight gained to calories consumed) was significantly decreased in DR as compared to DIO rats. Regarding leptin, a significant increase in both adipose tissue gene expression and serum levels was observed in DIO rats in comparison with other groups (control and DR). A significant increase in both adiponectin circulating levels and adipose tissue mRNA expression was also observed in DIO animals as compared with the other groups. These data suggest that the susceptibility to obesity of DIO rats might be secondary, at least in part, to an earlier development of leptin resistance, which could lead to alterations in food intake (hyperphagia) and energetic metabolism. However, neither changes in leptin or adiponectin seem to be involved in the adaptive mechanisms that confer resistance to high fat intake.
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Keywords {🔍}

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Topics {✒️}

los animales control month download article/chapter dieta de cafetería la adiponectina la leptina la obesidad high-fat diet induced la susceptibilidad en cuanto moreno-aliaga rights diet-induced obesity full article pdf fat mass weight male wistar rats privacy choices/manage cookies de miguel scheduled high-fat article pérez-echarri high fat intake gene expression levels adiponectin circulating levels high-sucrose diet standard laboratory diet european economic area scope submit manuscript se observó esto datos sugieren elucidating platelet dysfunction provocan resistencia conditions privacy policy check access instant access grupo control leptin resistance accepting optional cookies energetic metabolism moreno-aliaga article journal journal finder publish main content log control-fed animals confer resistance antagonist article 28 article log cafeteria-fed rats article cite susceptibilidad pérez-matute susceptibility dr rats

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      headline:Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity
      description:The aim of the present study was to identify the role of leptin and adiponectin in the development of resistance or susceptibility to diet-induced obesity in rats. For this purpose, male Wistar rats were fed with standard laboratory diet (control group) or cafeteria diet. After 15 days, two groups of rats with different response respect to the cafeteria diet were identified, and were assigned as diet-induced obesity (DIO) and diet resistant (DR) rats. The high-fat diet induced a very dignificant increase in both body and fat mass weight in DIO group. However, DR rats, gained even less weight than control-fed animals. Food intake was increased in cafeteria-fed rats (both DIO and DR) in comparison to control group; but hyperphagia was higher in DIO rats. In addition, feed efficiency (the ratio of weight gained to calories consumed) was significantly decreased in DR as compared to DIO rats. Regarding leptin, a significant increase in both adipose tissue gene expression and serum levels was observed in DIO rats in comparison with other groups (control and DR). A significant increase in both adiponectin circulating levels and adipose tissue mRNA expression was also observed in DIO animals as compared with the other groups. These data suggest that the susceptibility to obesity of DIO rats might be secondary, at least in part, to an earlier development of leptin resistance, which could lead to alterations in food intake (hyperphagia) and energetic metabolism. However, neither changes in leptin or adiponectin seem to be involved in the adaptive mechanisms that confer resistance to high fat intake.
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         Animal Physiology
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