We are analyzing https://link.springer.com/article/10.1007/s00125-005-0021-6.

Title:
Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study | Diabetologia
Description:
Aims/hypothesis Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. Results After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, ≥3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7–1.2), 1.1 (CI:0.9–1.5) and 1.4 (CI:1.1–1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend=0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, α1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. Conclusions/interpretation C3 is a risk factor for incurring large weight gain in middle-aged men.
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Keywords {🔍}

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Topics {✒️}

acylation-stimulating protein physiology serum gamma-glutamyl transferase cross-sectional studies healthy post-menopausal women population-based cohort study inflammation-sensitive plasma proteins swedish research council acylation-stimulating protein acylation stimulating protein privacy choices/manage cookies methods subject recruitment acute-phase proteins plasma protein determination fasting insulin×fasting glucose von willebrand factor article engström european economic area malmö university hospital inflammation-sensitive proteins acute-phase response modified shortened version inhibits intracellular lipolysis il1-β decrease clinically relevant approach adjustable gastric banding charlesworth ja cv mosby company lopez-soriano fj reactive oxygen species peake pw expanded-dose simvastatin homeostasis model assessment increased energy expenditure middle-aged males middle-aged adults major plasma proteins plasma protein levels body mass index conditions privacy policy complete birth cohorts screened birth cohorts increases plasma clearance serum complement proteins health service authority reflect dietary factors immune-complex deposition oral lipid loads coronary artery disease syskonen svenssons foundation type ii diabetes

Questions {❓}

Das UN (2001) Is obesity an inflammatory condition?

Schema {🗺️}

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         description:Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, ≥3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7–1.2), 1.1 (CI:0.9–1.5) and 1.4 (CI:1.1–1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend=0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, α1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. C3 is a risk factor for incurring large weight gain in middle-aged men.
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      headline:Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study
      description:Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, ≥3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7–1.2), 1.1 (CI:0.9–1.5) and 1.4 (CI:1.1–1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend=0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, α1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. C3 is a risk factor for incurring large weight gain in middle-aged men.
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