Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00210-023-02679-z, but it redirected us to https://link.springer.com/article/10.1007/s00210-023-02679-z. The analysis below is for the second page.

Title[redir]:
Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity | Naunyn-Schmiedeberg's Archives of Pharmacology
Description:
Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatment outcomes. The World Health Organization (WHO) has emphasised the development of not just new individual anti-TB drugs, but also novel medication regimens as an alternative treatment option for the drug-resistant Mtb strains. Many plants, as well as marine creatures (sponge; Haliclona sp.) and fungi, have been continuously used to treat TB in various traditional treatment systems around the world, providing an almost limitless supply of active components. Natural products, in addition to their anti-mycobacterial action, can be used as adjuvant therapy to increase the efficacy of conventional anti-mycobacterial medications, reduce their side effects, and reverse MDR Mtb strain due to Mycobacterium’s genetic flexibility and environmental adaptation. Several natural compounds such as quercetin, ursolic acid, berberine, thymoquinone, curcumin, phloretin, and propolis have shown potential anti-mycobacterial efficacy and are still being explored in preclinical and clinical investigations for confirmation of their efficacy and safety as anti-TB medication. However, more high-level randomized clinical trials are desperately required. The current review provides an overview of drug-resistant TB along with the latest anti-TB medications, drug-induced hepatotoxicity and oxidative stress. Further, the role and mechanisms of action of first and second-line anti-TB drugs and new drugs have been highlighted. Finally, the role of natural compounds as anti-TB medication and hepatoprotectants have been described and their mechanisms discussed.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, pubmed, google, scholar, pmid, cas, tuberculosis, central, mycobacterium, resistance, agents, zhang, wang, kumar, drug, med, httpsdoiorg, antimicrob, chemother, natural, httpsdoiorgaac, pandey, httpsdoiorgs, liu, drugs, products, review, treatment, kim, activity, hepatotoxicity, role, singh, antituberculosis, mechanisms, chem, action, clinical, liver, sci, drugresistant, antimycobacterial, potential, oxidative, stress, chen, isoniazid, van, lee, microbiol,

Topics {✒️}

int/publications/digital/global-tuberculosis-report-2021/tb-diagnosis-treatment/drug-resistant-treatment wijaya month download article/chapter decaprenylphosphoryl-β-d-arabinose biosynthetic nitroimidazole-oxazine-specific protein involved high-level ethambutol-resistant tuberculosis drug-induced liver injury multi-omics integration reveals anti-tuberculosis therapy-induced hepatotoxicity extensively drug-resistant tuberculosis long-term lipid diet nitro-dihydro-imidazooxazole derivative anti-mycobacterial natural products small-moleculenitroimidazopyran drug candidate drug-resistant mtb strains drug-induced liver toxicity exploring anti-tb leads enrich lung-resident memory acknowledges research associateship drug para-aminosalicylic acid selected medicinal plants conventional anti-mycobacterial medications multidrug-resistant pulmonary tuberculosis atds-induced hepatic damage hei-oc1 auditory cells d-cycloserine resistance trait difficult multidrug-resistant tuberculosis open chemistry 19 fluoroquinolone-resistant mycobacterium tuberculosis drug-resistant mycobacterium tuberculosis cisplatin-induced oxidative stress potential anti-tubercular leads alloxan-induced diabetic rats individual anti-tb drugs article naunyn-schmiedeberg' quercetin 3-o-glucoside recovered latest anti-tb medications line anti-tb drugs multidrug-resistant mycobacterium tuberculosis structure–microbicidal activity relationship extensively drug-resistant vitro anti-mycobacterial activity full article pdf unique c-terminal extension line anti-tuberculosis drugs pyrazinamide inhibits trans-translation global chemical composition drug-resistant strains antitubercular drugs-induced hepatotoxicity drug-resistant tb mycobacterial autophagosome formation

Questions {❓}

  • Field SK (2015) Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity
         description: Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatment outcomes. The World Health Organization (WHO) has emphasised the development of not just new individual anti-TB drugs, but also novel medication regimens as an alternative treatment option for the drug-resistant Mtb strains. Many plants, as well as marine creatures (sponge; Haliclona sp.) and fungi, have been continuously used to treat TB in various traditional treatment systems around the world, providing an almost limitless supply of active components. Natural products, in addition to their anti-mycobacterial action, can be used as adjuvant therapy to increase the efficacy of conventional anti-mycobacterial medications, reduce their side effects, and reverse MDR Mtb strain due to Mycobacterium’s genetic flexibility and environmental adaptation. Several natural compounds such as quercetin, ursolic acid, berberine, thymoquinone, curcumin, phloretin, and propolis have shown potential anti-mycobacterial efficacy and are still being explored in preclinical and clinical investigations for confirmation of their efficacy and safety as anti-TB medication. However, more high-level randomized clinical trials are desperately required. The current review provides an overview of drug-resistant TB along with the latest anti-TB medications, drug-induced hepatotoxicity and oxidative stress. Further, the role and mechanisms of action of first and second-line anti-TB drugs and new drugs have been highlighted. Finally, the role of natural compounds as anti-TB medication and hepatoprotectants have been described and their mechanisms discussed.
         datePublished:2023-09-04T00:00:00Z
         dateModified:2023-09-04T00:00:00Z
         pageStart:1251
         pageEnd:1273
         sameAs:https://doi.org/10.1007/s00210-023-02679-z
         keywords:
            Tuberculosis
            Drug-resistance
            Hepatoprotective
            Natural products
            Liver injury
            Pharmacology/Toxicology
            Neurosciences
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig6_HTML.png
         isPartOf:
            name:Naunyn-Schmiedeberg's Archives of Pharmacology
            issn:
               1432-1912
               0028-1298
            volumeNumber:397
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Harvesh Kumar Rana
               affiliation:
                     name:University of Allahabad
                     address:
                        name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                        type:PostalAddress
                     type:Organization
                     name:Feroze Gandhi College
                     address:
                        name:Department of Zoology, Feroze Gandhi College, Raebareli, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amit Kumar Singh
               affiliation:
                     name:University of Allahabad
                     address:
                        name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                        type:PostalAddress
                     type:Organization
                     name:BMK Government. Girls College
                     address:
                        name:Department of Botany, BMK Government. Girls College, Balod, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ramesh Kumar
               affiliation:
                     name:University of Allahabad
                     address:
                        name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                        type:PostalAddress
                     type:Organization
                     name:Central University of Punjab
                     address:
                        name:Department of Biochemistry, Central University of Punjab, Bathinda, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abhay K. Pandey
               affiliation:
                     name:University of Allahabad
                     address:
                        name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity
      description: Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatment outcomes. The World Health Organization (WHO) has emphasised the development of not just new individual anti-TB drugs, but also novel medication regimens as an alternative treatment option for the drug-resistant Mtb strains. Many plants, as well as marine creatures (sponge; Haliclona sp.) and fungi, have been continuously used to treat TB in various traditional treatment systems around the world, providing an almost limitless supply of active components. Natural products, in addition to their anti-mycobacterial action, can be used as adjuvant therapy to increase the efficacy of conventional anti-mycobacterial medications, reduce their side effects, and reverse MDR Mtb strain due to Mycobacterium’s genetic flexibility and environmental adaptation. Several natural compounds such as quercetin, ursolic acid, berberine, thymoquinone, curcumin, phloretin, and propolis have shown potential anti-mycobacterial efficacy and are still being explored in preclinical and clinical investigations for confirmation of their efficacy and safety as anti-TB medication. However, more high-level randomized clinical trials are desperately required. The current review provides an overview of drug-resistant TB along with the latest anti-TB medications, drug-induced hepatotoxicity and oxidative stress. Further, the role and mechanisms of action of first and second-line anti-TB drugs and new drugs have been highlighted. Finally, the role of natural compounds as anti-TB medication and hepatoprotectants have been described and their mechanisms discussed.
      datePublished:2023-09-04T00:00:00Z
      dateModified:2023-09-04T00:00:00Z
      pageStart:1251
      pageEnd:1273
      sameAs:https://doi.org/10.1007/s00210-023-02679-z
      keywords:
         Tuberculosis
         Drug-resistance
         Hepatoprotective
         Natural products
         Liver injury
         Pharmacology/Toxicology
         Neurosciences
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00210-023-02679-z/MediaObjects/210_2023_2679_Fig6_HTML.png
      isPartOf:
         name:Naunyn-Schmiedeberg's Archives of Pharmacology
         issn:
            1432-1912
            0028-1298
         volumeNumber:397
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Harvesh Kumar Rana
            affiliation:
                  name:University of Allahabad
                  address:
                     name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                     type:PostalAddress
                  type:Organization
                  name:Feroze Gandhi College
                  address:
                     name:Department of Zoology, Feroze Gandhi College, Raebareli, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amit Kumar Singh
            affiliation:
                  name:University of Allahabad
                  address:
                     name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                     type:PostalAddress
                  type:Organization
                  name:BMK Government. Girls College
                  address:
                     name:Department of Botany, BMK Government. Girls College, Balod, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ramesh Kumar
            affiliation:
                  name:University of Allahabad
                  address:
                     name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                     type:PostalAddress
                  type:Organization
                  name:Central University of Punjab
                  address:
                     name:Department of Biochemistry, Central University of Punjab, Bathinda, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abhay K. Pandey
            affiliation:
                  name:University of Allahabad
                  address:
                     name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Naunyn-Schmiedeberg's Archives of Pharmacology
      issn:
         1432-1912
         0028-1298
      volumeNumber:397
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Allahabad
      address:
         name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
         type:PostalAddress
      name:Feroze Gandhi College
      address:
         name:Department of Zoology, Feroze Gandhi College, Raebareli, India
         type:PostalAddress
      name:University of Allahabad
      address:
         name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
         type:PostalAddress
      name:BMK Government. Girls College
      address:
         name:Department of Botany, BMK Government. Girls College, Balod, India
         type:PostalAddress
      name:University of Allahabad
      address:
         name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
         type:PostalAddress
      name:Central University of Punjab
      address:
         name:Department of Biochemistry, Central University of Punjab, Bathinda, India
         type:PostalAddress
      name:University of Allahabad
      address:
         name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Harvesh Kumar Rana
      affiliation:
            name:University of Allahabad
            address:
               name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
               type:PostalAddress
            type:Organization
            name:Feroze Gandhi College
            address:
               name:Department of Zoology, Feroze Gandhi College, Raebareli, India
               type:PostalAddress
            type:Organization
      name:Amit Kumar Singh
      affiliation:
            name:University of Allahabad
            address:
               name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
               type:PostalAddress
            type:Organization
            name:BMK Government. Girls College
            address:
               name:Department of Botany, BMK Government. Girls College, Balod, India
               type:PostalAddress
            type:Organization
      name:Ramesh Kumar
      affiliation:
            name:University of Allahabad
            address:
               name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
               type:PostalAddress
            type:Organization
            name:Central University of Punjab
            address:
               name:Department of Biochemistry, Central University of Punjab, Bathinda, India
               type:PostalAddress
            type:Organization
      name:Abhay K. Pandey
      affiliation:
            name:University of Allahabad
            address:
               name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
      name:Department of Zoology, Feroze Gandhi College, Raebareli, India
      name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
      name:Department of Botany, BMK Government. Girls College, Balod, India
      name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
      name:Department of Biochemistry, Central University of Punjab, Bathinda, India
      name:Department of Biochemistry, University of Allahabad, Prayagraj (Allahabad), India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(563)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.52s.