
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Immunotherapy Converts Non-immunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation - PMC
Description:
Pancreatic ductal adenocarcinoma (PDAC) is considered a “non-Immunogenic” neoplasm. Single agent immunotherapies have failed to demonstrate significant clinical activity in PDAC and other “non-immunogenic” tumors, in part due to a complex tumor ...
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Keywords {🔍}
cells, doi, patients, lymphoid, aggregates, google, scholar, pubmed, immune, tcell, figure, expression, pdac, responses, cancer, pmc, tme, article, effector, gvax, tregs, til, free, intratumoral, tumors, tumor, gene, analysis, postvaccination, structures, activation, cell, survival, regulatory, treg, study, pathway, data, pdl, pancreatic, signals, immunol, ihc, vaccine, vaccinated, treatment, ratios, mesothelinspecific, immunotherapy, signatures,
Topics {✒️}
granulocyte-macrophage colony-stimulating factor mesothelin-specific t-cell responses antigen-specific t-cell responses post-vaccination t-cell activation vaccine-induced t-cell infiltration hla-a1-binding mesothelin epitopes post-gvax t-cell infiltration cd3+cd4+foxp3+treg levels measured pd-1/pd-l1-targeted immune modulation enhanced t-cell responses cd8+/foxp3+ t-cell ratio pre-validated pcr primers tumor-digested single-cell suspensions transforming growth factor-beta unenhanced t-cell responses altering t-cell responses vaccine-draining lymph nodes tgf-beta-dependent immunosuppressive activity anti-cd28-coated beads fluorescence-assisted cell sorting cytotoxic t-cell lysis single-agent anti-programmed death-1 pmc beta search improved post-vaccination responses t-cell activating signals activated t-cell responses t-cell ratio predicts myeloid-derived suppressor cells early t-cell activation aacr-fnab fellows grant t-cell modulating agents vaccination induces antigen-specific cd3−cd4−cd8−cd19− cells chemokine-mediated rapid turnover canonical nf-kb pathway cell-proliferation marker ki67 initial t-cell activation formalin-fixed paraffin-embedded irb-approved retrospective database dc-lamp+ mature dcs wilcoxon signed-rank tests t-helper pathway genes antigen-specific immune responses anti-human cd19-fitc t-cell zones located effector t-cell trafficking post-vaccination intratumoral teffector anti-human cd4-pecy5 patients remaining disease-free canonical nf-κb genes
Questions {❓}
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