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Title[redir]:
Journal of Immunotherapy
Description:
pancreas adenocarcinoma with measurable disease, good performance status, and minimal comorbidities. Ipilimumab was administered intravenously (3.0 mg/kg every 3 wk; 4 doses/course) for a maximum of 2 courses. Response rate by response evaluation criteria in solid tumors criteria and toxicity were measured. Twenty-seven subjects were enrolled (metastatic disease: 20 and locally advanced: 7) with median age of 55 years (27 to 68 y) and good performance status (26 with Eastern Cooperative Oncology Group performance status =0 to 1). Three subjects experienced ≥ grade 3 immune-mediated adverse events (colitis:1, encephalitis:1, hypohysitis:1). There were no responders by response evaluation criteria in solid tumors criteria but a subject experienced a delayed response after initial progressive disease. In this subject, new metastases after 2 doses of Ipilimumab established progressive disease. But continued administration of the agent per protocol resulted in significant delayed regression of the primary lesion and 20 hepatic metastases. This was reflected in tumor markers normalization, and clinically significant improvement of performance status. Single agent Ipilimumab at 3.0 mg/kg/dose is ineffective for the treatment of advanced pancreas cancer. However, a significant delayed response in one subject of this trial suggests that immunotherapeutic approaches to pancreas cancer deserve further exploration....
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Keywords {🔍}
journal, advanced, ipilimumab, response, issue, disease, performance, status, criteria, access, subscribe, alerts, authors, abstract, phase, trial, agent, locally, metastatic, pancreatic, adenocarcinoma, cancer, subjects, pancreas, subject, delayed, significant, log, register, logo, articles, issues, rosenberg, single, richard, buy, tumor, regression, good, evaluation, solid, tumors, experienced, progressive, metastases, text, subscribers, request, article, browse,
Topics {✒️}
0b013e3181eec14c buy abstract advanced pancreatic cancer good performance status advanced pancreas cancer full text access pancreatic ductal adenocarcinoma journal authors submit metastatic pancreas adenocarcinoma initial progressive disease immunologic tumor regression solid tumors criteria tumor markers normalization clinically significant improvement pancreas cancer deserve artificial intelligence training significant delayed regression response evaluation criteria etoc alerts significant delayed response 0 mg/kg/dose single agent ipilimumab service request 800-638-3030 register subscribe performance status individual subscribers log journal tables locally advanced issue subject experienced metastatic disease trial suggests delayed response 0 mg/kg website subscribe measurable disease journal response rate center submit anti-ctla-4 effective therapies minimal comorbidities administered intravenously median age continued administration protocol resulted primary lesion immunotherapeutic approaches ido-1 inhibitor email inbox rights reserved
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