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  6. Keywords
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We began analyzing https://www.nature.com/articles/1210392, but it redirected us to https://www.nature.com/articles/1210392. The analysis below is for the second page.

Title[redir]:
Differential regulation and properties of MAPKs | Oncogene
Description:
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1–3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.

Matching Content Categories {📚}

  • Education
  • Telecommunications
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, google, scholar, cas, kinase, protein, biol, cell, erk, central, chem, map, mitogenactivated, activation, kinases, mol, nature, jnk, regulation, signaling, cobb, scaffold, mapk, sci, access, article, nuclear, phosphorylation, regulates, dev, proc, natl, acad, usa, wang, pathway, activity, docking, content, chen, cjun, cascade, pathways, davis, phosphatase, cells, binding, mekk, cookies, oncogene,

Topics {✒️}

nature portfolio permissions reprints tissue research privacy policy c-jun n-terminal kinase advertising mitogen-activated protein kinase nature 411 nature 420 nature 372 nature p38 mitogen-activated protein rac-mekk3-mkk3 scaffolding social media stress-activated protein kinase-3 stress-activated protein kinase c-jun-nh2 kinase stress-activated protein kinases c-jun-dependent cell proliferation p38 stress-activated kinase author information authors activates c-jun nh c-myc protein stability regulatory c-terminal sequence extracellular signal-related kinase ras/map kinase signaling uv-responsive protein kinase c-jun activation domain autosomal-dominant polycystic kidneys nf-kappab signalling pathways extracellular signal-regulated kinase author correspondence extracellular signal-regulated kinases nuclear pore complex-mediated personal data springerlink instant access downregulates nf-kappab pathway positive-feedback kinase loop mp1-mapk scaffold complex p38 protein kinases c-jun nh coordinating erk/mapk signalling data protection permissions tpl2/erk-dependent pathway c-jun promoter map kinase cascades map kinase module map kinase kinase protein kinase involved

Schema {🗺️}

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         headline:Differential regulation and properties of MAPKs
         description:Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1–3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.
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      headline:Differential regulation and properties of MAPKs
      description:Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1–3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.
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         Cell Biology
         Human Genetics
         Oncology
         Apoptosis
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Social Networks {👍}(1)

External Links {🔗}(487)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Foundation
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  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

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Name Servers:

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CDN Services {📦}

  • Crossref

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