
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review) - PMC
Description:
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod-like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1, is by far ...
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Keywords {🔍}
doi, nlrp, inflammasome, pubmed, google, scholar, pmc, article, free, activation, inflammatory, wang, zhang, pyroptosis, disease, chen, injury, inhibitors, protein, cell, liu, inhibitor, inflammation, pathway, diseases, mice, diabetic, atherosclerosis, ilβ, signaling, gsdmd, targeting, caspase, tranilast, tlr, efflux, inhibiting, front, immunol, sun, effects, shown, receptor, treatment, mol, cells, colitis, inhibition, olt, inhibits,
Topics {✒️}
leucine-rich repeat low-density lipoprotein receptor ac-yvad-cmk ac-yvad-cmk high-fat diet ros/nf-κb/nlrp3/gsdmd signal axis vasp/nf-κb/nlrp3 inflammasome circuit tlr4/myd88/nf-κb/nlrp3 signaling pathway low-density lipoprotein oxygen-glucose deprivation/reperfusion injury diet-induced diabetes models reactive oxygen species rip1/rip3/akt signaling pathway ttlr4/nf-κb/nlrp3 pathway lps/atp-induced ldh release β-amyloid-induced neuronal pyroptosis high-fat feeding directional coronary atherectomy cryopyrin/nalp3 binds atp/datp cold-inducible rna-binding protein attenuates lipopolysaccharide-induced sepsis fgfr1/tlr4/nlrp3 inflammasome pathway lps-induced il-1β release oxygen-glucose deprivation/reoxygenation nlrp3/il-1β/cxcl1 signaling myocardial infarction activation steps-structure-activity-relationship ac-yvad-cmk responds cerebral ischemia/reperfusion injury cerebral ischemia-reperfusion injury inhibiting nf-κb/gsdmd signal β-sulfonyl nitrile compound 4-methylenedioxy-β-nitrostyrene ac-yvad-cmk reduces inactivating tlr4/nlrp3/caspase-1 pathway ros/txnip/nlrp3 inflammasome pathway ros-txnip-nlrp3 inflammasome pathway ultimately activates nf-κb hypoxia/reoxygenation-induced injury dss-induced acute colitis polyphyllin vi-induced activation endoplasmic reticulum ventilator-induced lung injury blood-brain barrier dysfunction gaba-induced nlrp3 inflammasome nitric oxide-dependent neurodegeneration jak2/stat3 signaling pathway mediate nf-κb entry mouse monocyte/macrophage cells phorbol 12-myristate 13-acetate-differentiated subsequent nf-κb signaling
Questions {❓}
- Brain metabolism alterations in type 2 diabetes: What did we learn from diet-induced diabetes models?
- Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Sci%20Immunol&title=Chemical%20disruption%20of%20the%20pyroptotic%20pore-forming%20protein%20gasdermin%20D%20inhibits%20inflammatory%20cell%20death%20and%20sepsis&author=JK%20Rathkey&author=J%20Zhao&author=Z%20Liu&author=Y%20Chen&author=J%20Yang&volume=3&publication_year=2018&pages=eaat2738&pmid=30143556&doi=10.1126/sciimmunol.aat2738&?
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- How much does https://scholar.google.com/scholar_lookup?journal=Front%20Pharmacol&title=Application%20of%20Disulfiram%20and%20its%20metabolites%20in%20treatment%20of%20inflammatory%20disorders&author=W%20Guo&author=S%20Chen&author=C%20Li&author=J%20Xu&author=L%20Wang&volume=12&publication_year=2021&pages=795078&pmid=35185542&doi=10.3389/fphar.2021.795078& make?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Nephrol%20Dial%20Transpl&title=Effect%20of%20Tranilast%20in%20early-stage%20diabetic%20nephropathy&author=J%20Soma&author=K%20Sato&author=H%20Saito&author=Y%20Tsuchiya&volume=21&publication_year=2006&pages=2795-2799&pmid=16820373&doi=10.1093/ndt/gfl325&
- What's the total monthly financial gain of https://doi.org/10.1016/S0002-8703(97)70055-3?
- Profit of https://scholar.google.com/scholar_lookup?journal=Am%20Heart%20J&title=Effectiveness%20of%20Tranilast%20on%20restenosis%20after%20directional%20coronary%20atherectomy&author=K%20Kosuga&author=H%20Tamai&author=K%20Ueda&author=YS%20Hsu&author=S%20Ono&volume=134&publication_year=1997&pages=712-718&pmid=9351739&doi=10.1016/S0002-8703(97)70055-3&
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- How much does https://scholar.google.com/scholar_lookup?journal=J%20Cardiovasc%20Pharm&title=Phase%201B,%20randomized,%20Double-blinded,%20dose%20escalation,%20single-center,%20repeat%20dose%20safety%20and%20pharmacodynamics%20study%20of%20the%20oral%20NLRP3%20inhibitor%20dapansutrile%20in%20subjects%20with%20NYHA%20II-III%20systolic%20heart%20failure&author=GF%20Wohlford&author=BW%20Van%20Tassell&author=HE%20Billingsley&author=D%20Kadariya&author=JM%20Canada&volume=77&publication_year=2020&pages=49-60&pmid=33235030&doi=10.1097/FJC.0000000000000931& net monthly?
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