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We began analyzing https://link.springer.com/protocol/10.1007/978-1-0716-2144-8_9, but it redirected us to https://link.springer.com/protocol/10.1007/978-1-0716-2144-8_9. The analysis below is for the second page.

Title[redir]:
Intracellular Potassium Ion Measurements by Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES) | SpringerLink
Description:
Potassium ion (K+) efflux is often considered as an upstream signaling event of NLRP3 activation. The main evidence to demonstrate the importance of K+ efflux is that high concentration of extracellular K+ inhibits NLRP3 inflammasome assembly. However, the conditions...

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Intracellular Potassium Ion Measurements by Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES)
      pageEnd:92
      pageStart:85
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-0716-2144-8.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:The Inflammasome
         isbn:
            978-1-0716-2144-8
            978-1-0716-2143-1
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         name:Springer US
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      author:
            name:Yifei Zhang
            affiliation:
                  name:Tianjin University
                  address:
                     name:Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Shi
            affiliation:
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                  address:
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                     type:PostalAddress
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                     name:Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada
                     type:PostalAddress
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                  name:University of Calgary
                  address:
                     name:Snyder Institute, University of Calgary, Calgary, Canada
                     type:PostalAddress
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            email:[email protected]
            type:Person
      keywords:NLRP3 inflammasome, Intracellular K+ content
      description:Potassium ion (K+) efflux is often considered as an upstream signaling event of NLRP3 activation. The main evidence to demonstrate the importance of K+ efflux is that high concentration of extracellular K+ inhibits NLRP3 inflammasome assembly. However, the conditions used to prevent K+ flowing also breaks down a basic parameter of eukaryotic biology, leading to sustained membrane potential depolarization and affecting normal signal transduction in cells. Therefore, direct measurement of intracellular ion concentration can more truly reflect the role of K+ flow during the activation of NLRP3. In this chapter, we will provide the rationale and a method to evaluate intracellular K+ concentration by ICP-OES (Inductively Coupled Plasma Optical Emission Spectroscopy), which helps us understand how disturbances in intracellular K+ level orchestrates NLRP3 inflammasome activation.
      datePublished:2022
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Book:
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      name:Tianjin University
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         name:Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China
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         name:Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada
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               type:PostalAddress
            type:Organization
      name:Yan Shi
      affiliation:
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               name:Tsinghua Institute for Immunology and Department of Basic Medical Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, School of Medicine, Tsinghua University, Beijing, China
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            address:
               name:Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada
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      name:Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China
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      name:Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China
      name:Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada
      name:Snyder Institute, University of Calgary, Calgary, Canada
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