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We began analyzing https://www.nature.com/articles/cmi201595, but it redirected us to https://www.nature.com/articles/cmi201595. The analysis below is for the second page.

Title[redir]:
Molecular mechanisms regulating NLRP3 inflammasome activation | Cellular & Molecular Immunology
Description:
Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inflammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome.

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Keywords {🔍}

pubmed, article, google, scholar, cas, inflammasome, nlrp, central, activation, immunol, nature, cell, biol, nat, inflammasomes, kim, signaling, inflammation, chem, regulates, inflammatory, access, activates, sci, rev, tschopp, mol, mitochondrial, ilβ, van, lee, processing, molecular, mechanisms, diseases, immunity, nalp, role, acad, research, content, release, death, pathway, med, receptor, proc, natl, secretion, cookies,

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megalin/cubulin-lysosome-mediated albumin reabsorption nature portfolio permissions reprints privacy policy brain regional differences national research foundation rip1-rip3-drp1 signaling pathway advertising cias1/cryopyrin/pypaf1/nalp3/caterpiller 1 caspase-1-dependent lysosome exocytosis social media jin kyung kim research trend staphylococcus aureus-induced activation lps-induced sickness behavior lps-induced septic shock streptococcus induce interleukin-1β calcium-sensing receptor regulates tlr4/tak1/irf7 axis author information authors particle-mediated inflammasome activation targeting pro-il-1beta diet-induced insulin resistance negatively regulates activation multi-protein signaling complexes cardiovascular excitation-contraction coupling microtubule-driven spatial arrangement eun-kyeong jo nature 1992 nature 2006 nature 2008 nature 2011 nature 2009 nature 2010 nature 2012 nature 2014 nature author correspondence interleukin-1beta converting enzyme asc-dependent inflammasomes nucleotide-binding oligomerization domain trif-dependent pathway il-1beta inflammasome personal data anti-fungal host defence springerlink instant access mitochondrial dna mediated rna virus infection p-coumaric acid mitochondria promotes activation

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