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cells, pubmed, fig, cxxc, article, crpc, enzr, expression, data, cell, google, scholar, cancer, cenzr, tet, cas, supplementary, central, loci, genes, analysis, noncanonical, prostate, enz, neo, binding, target, arbsgained, growth, gene, control, protein, resistance, pfn, nature, inhibitors, signaling, ccon, treatment, androgen, pca, proteins, dilution, compared, statistical, chipseq, enzresistant, receptor, inhibitor, rnaseq,

Topics {✒️}

nature portfolio privacy policy advertising bet-cbp/p300 dual inhibitor tumor volume = length × width × width × 0 bet-cbp/p300 dual inhibitors social media constitutively open chromatin androgen-dependent ar-occupied regions enhancer-driven lineage-specific transcription wild-type prostate cancer reprints research design androgen-independent ar-occupied regions de novo-motif discovery cbp/p300 inhibitor cpi63742 androgen-refractory prostate cancer japan chip-seq libraries castration-resistant prostate cancer histone acetyltransferases p300/cbp nature 474 nature 489 nature 497 nature 401 nature 510 nature fast gapped-read alignment genome-wide rna-seq arbs-gained-cpgi gene loci cell lineage development androgen-dependent occupied regions su2c/pcf dream team linked-read genome sequencing arbs-gained cpgi-positive sites reporting summary express full-length ar rna-seq analysis revealed open platform noncanonical ar-dependent function transcriptional profiling identifies selective swi/snf dependencies ar-negative/low crpc variants androgen receptor activity-low androgen receptor-suppressed driver ar-dependent mechanism responsible generation anti-androgen enzalutamide long-range interaction landscape precipitated protein-dna complexes noncanonical ar-targeted genes

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         headline:A noncanonical AR addiction drives enzalutamide resistance in prostate cancer
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            name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science
            address:
               name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Zhenqing Ye
      affiliation:
            name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science
            address:
               name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Jacob J. Orme
      url:http://orcid.org/0000-0002-0319-0239
      affiliation:
            name:Division of Medical Oncology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science
            address:
               name:Division of Medical Oncology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Dong Lin
      affiliation:
            name:Department of Experimental Therapeutics, BC Cancer Research Centre
            address:
               name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Haoyue Sheng
      affiliation:
            name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Ladan Fazli
      affiliation:
            name:Department of Experimental Therapeutics, BC Cancer Research Centre
            address:
               name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:R. Jeffrey Karnes
      affiliation:
            name:Department of Urology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Rafael Jimenez
      url:http://orcid.org/0000-0003-2348-0214
      affiliation:
            name:Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Liguo Wang
      url:http://orcid.org/0000-0003-2072-4826
      affiliation:
            name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science
            address:
               name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Liewei Wang
      affiliation:
            name:Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Martin E. Gleave
      affiliation:
            name:University of British Columbia
            address:
               name:The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Yuzhuo Wang
      url:http://orcid.org/0000-0002-9749-8591
      affiliation:
            name:Department of Experimental Therapeutics, BC Cancer Research Centre
            address:
               name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
               type:PostalAddress
            type:Organization
            name:University of British Columbia
            address:
               name:The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Lei Shi
      affiliation:
            name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Haojie Huang
      url:http://orcid.org/0000-0003-2751-6413
      affiliation:
            name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
            name:Department of Urology, Mayo Clinic College of Medicine and Science
            address:
               name:Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
            name:Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science
            address:
               name:Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Division of Medical Oncology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
      name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
      name:Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada
      name:Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, Canada
      name:The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada
      name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, USA
      name:Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, USA

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