
NCBI . NLM . NIH . GOV {
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Title[redir]:
Ever-changing landscapes: transcriptional enhancers in development and evolution - PMC
Description:
A class of cis-regulatory elements called enhancers plays a central role in orchestrating spatio-temporally precise gene expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important ...
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Keywords {🔍}
doi, google, scholar, pubmed, enhancers, enhancer, pmc, article, free, gene, regulatory, cell, binding, expression, elements, evolution, dna, tad, activity, chromatin, function, genome, transcription, genes, domains, figure, sequences, human, drosophila, cisregulatory, organization, sites, transcriptional, nature, regulation, tfs, domain, ctcf, genet, genomic, interactions, mammalian, jcell, complex, topological, evolutionary, role, species, multiple, functional,
Topics {✒️}
�/c-iv/c-ii gene cluster mammalian viral-inducible interferon-β [google scholar] buecker show site-specific binding pmc beta search neural plate-specific otx cas9-histone demethylase fusion de la calle-mustienes long-range chromosomal interactions tissue-specific regulatory interactions gap gene-expression patterns α-globin super-enhancer primate-specific regulatory sequences local cis-regulatory landscape gc-biased gene conversion long-range gene regulation recent genome-wide mapping distributed cis-regulatory information ltr-mediated gene regulation direct protein-protein interactions intra-species phenotypic variation gal4 dna-binding domain pair-wise tf binding drive tissue-specific expression future cis-regulatory evolution genomic cis-regulatory logic long-range enhancer function parasegment-specific chromosomal domains genome-scale functional characterization enforcing promoter-enhancer looping recent live-imaging studies threshold-dependent gene activation tissue-specific enhancer elements phillips-cremins typical enhancer-promoter contacts characterized domain-restricted system nearby liver-specific genes modular cis-regulatory organization de novo gains demonstrated heart-specific activity organize regulatory landscapes evolving enhancer-promoter interactions mediator establish super-enhancers highly dynamic view rada-iglesias el-sherif gallego romero enhancer-mediated transcriptional activation core binding site context-dependent regulatory functions
Questions {❓}
- Adaptation or biased gene conversion?
- Modification of Enhancer Chromatin: What, How, and Why?
- These observations beg several questions: What are the regulatory relationships among simultaneously active enhancers?
- Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
- What Does It Take to Evolve an Enhancer?
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- https://scholar.google.com/scholar_lookup?journal=A%20panel%20of%20induced%20pluripotent%20stem%20cells%20from%20chimpanzees:%20a%20resource%20for%20comparative%20functional%20genomics&author=I%20Gallego%20Romero&author=BJ%20Pavlovic&author=I%20Hernando-Herraez&author=X%20Zhou&author=MC%20Ward&publication_year=2015&pages=1-29&pmid=26102527&doi=10.7554/eLife.07103&'s financial summary
- https://doi.org/10.1016/j.tig.2007.03.011's total income per month
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- Income figures for https://doi.org/10.1016/j.cell.2014.03.025
- https://scholar.google.com/scholar_lookup?journal=Cell&title=Predictive%20polymer%20modeling%20reveals%20coupled%20fluctuations%20in%20chromosome%20conformation%20and%20transcription.&author=L%20Giorgetti&author=R%20Galupa&author=EP%20Nora&author=T%20Piolot&author=F%20Lam&volume=157&publication_year=2014&pages=950-963&pmid=24813616&doi=10.1016/j.cell.2014.03.025&'s total income per month
- Profit of https://doi.org/10.1038/nature18589
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- How much profit does https://doi.org/10.1242/dev.055996 generate?
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- Learn how profitable https://doi.org/10.1016/j.celrep.2013.03.014 is on a monthly basis
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=Genomic%20regions%20flanking%20E-box%20binding%20sites%20influence%20DNA%20binding%20specificity%20of%20bHLH%20transcription%20factors%20through%20DNA%20shape.&author=R%20Gord%C3%A2n&author=N%20Shen&author=I%20Dror&author=T%20Zhou&author=J%20Horton&volume=3&publication_year=2013&pages=1093-1104&pmid=23562153&doi=10.1016/j.celrep.2013.03.014&?
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- What's https://doi.org/10.1016/j.cell.2015.07.048's gross income?
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- See how much https://scholar.google.com/scholar_lookup?journal=Cell&title=CRISPR%20Inversion%20of%20CTCF%20Sites%20Alters%20Genome%20Topology%20and%20Enhancer/Promoter%20Function.&author=Y%20Guo&author=Q%20Xu&author=D%20Canzio&author=J%20Shou&author=J%20Li&volume=162&publication_year=2015&pages=900-910&pmid=26276636&doi=10.1016/j.cell.2015.07.038& makes per month
- Earnings of https://doi.org/10.1098/rstb.2013.0029
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- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Topologically%20associated%20domains%20are%20ancient%20features%20that%20coincide%20with%20Metazoan%20clusters%20of%20extreme%20noncoding%20conservation&author=N%20Harmston&author=E%20Ing-simmons&author=G%20Tan&author=M%20Perry&author=M%20Merkenschlager&publication_year=2016&pmid=28874668&doi=10.1038/s41467-017-00524-5&
- How much does https://doi.org/10.1038/ng.3605 pull in?
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- How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci&title=The%20chromatin%20insulator%20CTCF%20and%20the%20emergence%20of%20metazoan%20diversity.&author=P%20Heger&author=B%20Marin&author=M%20Bartkuhn&author=E%20Schierenberg&author=T%20Wiehe&volume=109&publication_year=2012&pages=17507-17512&pmid=23045651&doi=10.1073/pnas.1111941109& pull in?
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- How much income does https://doi.org/10.1016/j.cell.2013.09.053 have?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cell&title=Super-enhancers%20in%20the%20control%20of%20cell%20identity%20and%20disease.&author=D%20Hnisz&author=BJ%20Abraham&author=TI%20Lee&author=A%20Lau&author=V%20Saint-Andr%C3%A9&volume=155&publication_year=2013&pages=934-947&pmid=24119843&doi=10.1016/j.cell.2013.09.053&?
- How much does https://doi.org/10.1126/science.1160631 pull in monthly?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Science%20(80%E2%88%92.%20)&title=Shadow%20Enhancers%20as%20a%20Source%20of%20Evolutionary%20Novelty.&author=J-W%20Hong&author=DA%20Hendrix&author=MS%20Levine&volume=321&publication_year=2008&pages=1314&pmid=18772429&doi=10.1126/science.1160631&?
- How much does https://doi.org/10.1016/j.molcel.2012.08.031 make?
- How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell&title=Gene%20Density,%20Transcription,%20and%20Insulators%20Contribute%20to%20the%20Partition%20of%20the%20Drosophila%20Genome%20into%20Physical%20Domains.&author=C%20Hou&author=L%20Li&author=ZS%20Qin&author=VG%20Corces&volume=48&publication_year=2012&pages=471-484&pmid=23041285&doi=10.1016/j.molcel.2012.08.031& generate monthly?
- What's the financial gain of https://doi.org/10.1371/journal.pgen.1001260?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=PLoS%20Genet&title=Initiator%20Elements%20Function%20to%20Determine%20the%20Activity%20State%20of%20BX-C%20Enhancers.&author=C%20Iampietro&author=M%20Gummalla&author=A%20Mutero&author=F%20Karch&author=RK%20Maeda&volume=6&publication_year=2010&pages=e1001260&pmid=21203501&doi=10.1371/journal.pgen.1001260& bring in?
- How much revenue does https://doi.org/10.1371/journal.pgen.1003504 generate?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=PLoS%20Genet&title=The%20Majority%20of%20Primate-Specific%20Regulatory%20Sequences%20Are%20Derived%20from%20Transposable%20Elements.&author=P-%C3%89%20Jacques&author=J%20Jeyakani&author=G%20Bourque&volume=9&publication_year=2013&pages=e1003504&pmid=23675311&doi=10.1371/journal.pgen.1003504& bring in?
- What are the earnings of https://doi.org/10.1038/nature15518?
- How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=DNA-dependent%20formation%20of%20transcription%20factor%20pairs%20alters%20their%20binding%20specificity.&author=A%20Jolma&author=Y%20Yin&author=KR%20Nitta&author=K%20Dave&author=A%20Popov&volume=527&publication_year=2015&pages=384-388&pmid=26550823&doi=10.1038/nature15518& make?
- Income figures for https://doi.org/10.1038/nrg3230
- https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Genet&title=Functions%20of%20DNA%20methylation:%20islands,%20start%20sites,%20gene%20bodies%20and%20beyond.&author=PA%20Jones&volume=13&publication_year=2012&pages=484-492&pmid=22641018&doi=10.1038/nrg3230&'s financial summary
- How much does https://doi.org/10.1016/j.cell.2012.01.030 make?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Cell&title=A%20Transcription%20Factor%20Collective%20Defines%20Cardiac%20Cell%20Fate%20and%20Reflects%20Lineage%20History.&author=G%20Junion&author=M%20Spivakov&author=C%20Girardot&author=M%20Braun&author=EH%20Gustafson&volume=148&publication_year=2012&pages=473-486&pmid=22304916&doi=10.1016/j.cell.2012.01.030&
- What's the monthly income of https://doi.org/10.1038/nmeth.3325?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Nat.%20Methods&title=Functional%20annotation%20of%20native%20enhancers%20with%20a%20Cas9-histone%20demethylase%20fusion.&author=N.%20a%20Kearns&author=H%20Pham&author=B%20Tabak&author=RM%20Genga&author=NJ%20Silverstein&volume=12&publication_year=2015&pages=401-403&pmid=25775043&doi=10.1038/nmeth.3325&?
- How much revenue does https://doi.org/10.1016/j.cell.2015.08.008 bring in?
- https://scholar.google.com/scholar_lookup?journal=Cell&title=Architectural%20and%20Functional%20Commonalities%20between%20Enhancers%20and%20Promoters.&author=T-K%20Kim&author=R%20Shiekhattar&volume=162&publication_year=2015&pages=948-959&pmid=26317464&doi=10.1016/j.cell.2015.08.008&'s total income per month
- Learn how profitable https://doi.org/10.1371/journal.pgen.0040029 is on a monthly basis
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=PLoS%20Genet&title=Subfunctionalization%20of%20Duplicated%20Zebrafish%20pax6%20Genes%20by%20cis-Regulatory%20Divergence.&author=DA%20Kleinjan&author=RM%20Bancewicz&author=P%20Gautier&author=R%20Dahm&author=HB%20Schonthaler&volume=4&publication_year=2008&pages=e29&pmid=18282108&doi=10.1371/journal.pgen.0040029&?
- What's the total monthly financial gain of https://doi.org/10.1186/1756-8935-5-1?
- How much does https://scholar.google.com/scholar_lookup?journal=Epigenetics%20Chromatin&title=Enhancers%20and%20silencers:%20an%20integrated%20and%20simple%20model%20for%20their%20function.&author=P%20Kolovos&author=T.%20a%20Knoch&author=FG%20Grosveld&author=PR%20Cook&author=A%20Papantonis&volume=5&publication_year=2012&pages=1&pmid=22230046&doi=10.1186/1756-8935-5-1& rake in every month?
- Revenue of https://doi.org/10.1093/molbev/msr279
- How much income does https://scholar.google.com/scholar_lookup?journal=Mol.%20Biol.%20Evol&title=The%20role%20of%20GC-Biased%20gene%20conversion%20in%20shaping%20the%20fastest%20evolving%20regions%20of%20the%20human%20genome.&author=D%20Kostka&author=MJ%20Hubisz&author=A%20Siepel&author=KS%20Pollard&volume=29&publication_year=2012&pages=1047-1057&pmid=22075116&doi=10.1093/molbev/msr279& have?
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- How much does https://scholar.google.com/scholar_lookup?journal=Cell%20Biosci&title=On%20the%20way%20of%20revealing%20coactivator%20complexes%20cross-talk%20during%20transcriptional%20activation.&author=AN%20Krasnov&author=MY%20Mazina&author=JV%20Nikolenko&author=NE%20Vorobyeva&volume=6&publication_year=2016&pages=15&pmid=26913181&doi=10.1186/s13578-016-0081-y& gross monthly?
- How much revenue does https://doi.org/10.1038/nature13395 bring in?
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- https://doi.org/10.1093/hmg/ddg180 income
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- How much does https://doi.org/10.1101/gr.185033.114 rake in every month?
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- See how much https://doi.org/10.1038/35000615 makes per month
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- What's the financial intake of https://doi.org/10.1038/ng.917?
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- Check the income stats for https://doi.org/10.1016/j.gde.2011.01.021
- How much money does https://scholar.google.com/scholar_lookup?journal=Curr.%20Opin.%20Genet.%20Dev&title=Gene%20expression%20in%20time%20and%20space:%20additive%20vs%20hierarchical%20organization%20of%20cis-regulatory%20regions.&author=RK%20Maeda&author=F%20Karch&volume=21&publication_year=2011&pages=187-193&pmid=21349696&doi=10.1016/j.gde.2011.01.021& generate?
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- https://doi.org/10.1038/nrg2901's financial summary
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Genet&title=The%20metazoan%20Mediator%20co-activator%20complex%20as%20an%20integrative%20hub%20for%20transcriptional%20regulation.&author=S%20Malik&author=RG%20Roeder&volume=11&publication_year=2010&pages=761-772&pmid=20940737&doi=10.1038/nrg2901&
- Check the income stats for https://doi.org/10.1016/j.devcel.2013.01.025
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- See how much https://doi.org/10.1007/BF00226448 makes per month
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- Earnings of https://doi.org/10.1038/ng.1006
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- https://doi.org/10.1242/dev.02451's financial summary
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