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Title[redir]:
Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer - PMC
Description:
Over the past ten years, preclinical studies implicating sustained androgen receptor (AR) signaling as the primary driver of castration resistant prostate cancer (CRPC) led to the development of novel agents targeting the AR pathway that are now in ...
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Keywords {π}
doi, cancer, prostate, google, scholar, pubmed, androgen, receptor, pmc, article, free, resistance, crpc, patients, enzalutamide, cell, abiraterone, clinical, mutations, cells, metastatic, expression, pca, treatment, castration, human, res, signaling, levels, arv, binding, castrationresistant, mechanisms, men, tumor, inhibitors, therapy, hormone, progression, clin, studies, resistant, genomic, figure, antiandrogen, dna, testosterone, gene, splice, activity,
Topics {βοΈ}
future therapeutic options canonical full-length ar circulating cell-free dna block castration-induced apoptosis androgen-independent prostate cancer ar-v7 restored sensitivity castration-resistant tumor growth full-length receptor extra-gonadal androgen biosynthesis glossary terms androgen hormone-refractory prostate cancer castration-resistant prostate cancer promote androgen-independent growth pmc beta search gonadotropin-releasing hormone blockers pi3k-akt-mtor pathway pi3k/akt/mtor pathway castrate-resistant prostate cancer complete carboxy-terminal lbd hypothalamic-pituitary-testicular axis tmprss2-erg gene fusion hormones gonadotropin-releasing hormone ligand binding domain supplementary materials included luteinizing hormone-releasing hormone androgen receptor variants possess anti-inflammatory activity ligand-mediated ar activation castrate-recurrent prostate cancer human androgen receptor androgen receptor signaling pten-deficient prostate cancer gov/statfacts/html/prost prostate-specific antigen testing high-risk localized pca ar splice variants serum free conditions restored ar signaling typical ar-positive adenocarcinomas amino-terminal transactivation cell-based model system androgen receptor gene complete ar independence androgen receptor protein heavily pre-treated crpc overcoming mutation-based resistance androgen receptor binding human prostatic carcinoma ar-negative primary pca numerous derived sublines
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- Testosterone surge: rationale for gonadotropin-releasing hormone blockers?
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- What is the monthly revenue of https://doi.org/10.1046/j.1464-410x.2000.00606.x?
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- How much does https://doi.org/10.1038/nm0497-402 pull in monthly?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Progression%20of%20metastatic%20human%20prostate%20cancer%20to%20androgen%20independence%20in%20immunodeficient%20SCID%20mice&author=KA%20Klein&volume=3&publication_year=1997&pages=402-408&pmid=9095173&doi=10.1038/nm0497-402&
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Prog%20Clin%20Biol%20Res&title=The%20LNCaP%20cell%20line--a%20new%20model%20for%20studies%20on%20human%20prostatic%20carcinoma&author=JS%20Horoszewicz&volume=37&publication_year=1980&pages=115-132&pmid=7384082&?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=LNCaP%20model%20of%20human%20prostatic%20carcinoma&author=JS%20Horoszewicz&volume=43&publication_year=1983&pages=1809-1818&pmid=6831420&?
- How much profit does https://doi.org/10.1002/ijc.2910570319 make?
- https://scholar.google.com/scholar_lookup?journal=Int%20J%20Cancer&title=Derivation%20of%20androgen-independent%20human%20LNCaP%20prostatic%20cancer%20cell%20sublines:%20role%20of%20bone%20stromal%20cells&author=HC%20Wu&volume=57&publication_year=1994&pages=406-412&pmid=8169003&doi=10.1002/ijc.2910570319&'s financial summary
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=Establishment%20of%20two%20human%20prostate%20cancer%20cell%20lines%20derived%20from%20a%20single%20bone%20metastasis&author=NM%20Navone&volume=3&publication_year=1997&pages=2493-2500&pmid=9815652&?
- Profit of https://doi.org/10.1016/S0022-5347(05)68158-X
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Urol&title=Two%20mutations%20identified%20in%20the%20androgen%20receptor%20of%20the%20new%20human%20prostate%20cancer%20cell%20line%20MDA%20PCa%202a&author=XY%20Zhao&volume=162&publication_year=1999&pages=2192-2199&pmid=10569618&doi=10.1016/S0022-5347(05)68158-X& generate monthly?
- How much money does https://scholar.google.com/scholar_lookup?journal=Invest%20Urol&title=Establishment%20and%20characterization%20of%20a%20human%20prostatic%20carcinoma%20cell%20line%20(PC-3)&author=ME%20Kaighn&author=KS%20Narayan&author=Y%20Ohnuki&author=JF%20Lechner&author=LW%20Jones&volume=17&publication_year=1979&pages=16-23&pmid=447482& make?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=In%20Vivo&title=VCaP,%20a%20cell-based%20model%20system%20of%20human%20prostate%20cancer&author=S%20Korenchuk&volume=15&publication_year=2001&pages=163-168&pmid=11317522&
- Check the income stats for https://doi.org/10.1593/neo.08428
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