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figure, cancer, prostate, scholar, google, doi, pubmed, pmc, article, samples, free, table, dna, brca, tumor, alterations, analysis, sequencing, structural, gene, mcrpc, genes, biallelic, genome, mutation, cases, frequency, number, mutations, tandem, chromothripsis, expression, copy, identified, tumors, data, amplification, fusions, region, related, repair, somatic, supplemental, duplication, inactivation, nature, metastatic, performed, rna, sample,

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pcr-free paired-end libraries grant number su2c-aacr-dt0812 foundation scholar grant double-strand dna breaks [google scholar] raczy pmc beta search similar acpp-axl fusion roche/ventana medical systems compound brca1-brca2 heterozygosity castration-resistant metastatic patients multi-institutional consortium conducted ras/mapk pathway members full-length pik3ca transcript image-guided core biopsies light/dark green circles ncbi grch38 par-masked org/cancer/cga/chainfinder high-throughput sequencing data goldberg-benioff research fund microhomology-mediated end joining 2x76bp paired-end runs alternative nonhomologous end-joining ct–guided bone biopsies supplementary materials included activation-induced deaminase activity dna damage repair post-translational myc regulation generation anti-androgen therapy advanced prostate cancer wider green/blue bars pre-fragmentation gdna cleanup frequent copy gain/loss previous pan-cancer analysis genome-wide ploidy estimates dna repair defects dna-repair defects prostate cancer identifies aggressive prostate cancers real-time image analysis produce genomic scars prospective irb-approved study castration-resistant disease primary prostate cancer prostate cancer risk metastatic prostate cancer small case series mismatch repair defects sample-level features related indolent prostate cancer patterned flow cells

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