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NATURE . COM {}

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  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
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We are analyzing https://www.nature.com/articles/s41467-019-13668-3.

Title:
Mitochondrial TCA cycle metabolites control physiology and disease | Nature Communications
Description:
Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to the rest of the cell. Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin modifications, DNA methylation, the hypoxic response, and immunity. This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts. We will focus on how these metabolites mediated signaling can affect physiology and disease. Mitochondrial metabolites contribute to more than biosynthesis, and it is clear that they influence multiple cellular functions in a variety of ways. Here, Martínez-Reyes and Chandel review key metabolites and describe their effects on processes involved in physiology and disease including chromatin dynamics, immunity, and hypoxia.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Education
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

pubmed, article, google, scholar, cas, cell, cycle, central, tca, mitochondrial, cells, acetylcoa, succinate, levels, fumarate, αkg, histone, cancer, nature, signaling, activity, ads, function, metabolites, dna, production, itaconate, metabolic, acetylation, complex, mitochondria, functions, lhg, enzymes, macrophages, expression, cellular, regulation, dehydrogenase, methylation, genes, control, gene, fig, accumulation, mutations, including, chromatin, pathway, metabolism,

Topics {✒️}

nature portfolio privacy policy orphan g-protein-coupled receptors advertising pro-inflammatory cytokine il-1β65 il-17–iκbζ-driven skin pathology social media fascinating development reprints l-ascorbic acid-driven angiogenesis trigger epithelial-mesenchymal transition akt-mtorc1 signaling axis author information authors article martínez-reyes fatty acid beta-oxidation mitochondrial respiratory-chain adaptations wild-type showed differences alpha-ketoglutarate-dependent dioxygenases akt-acly signaling axis21 nmr-based metabolomic profiling ikappabzeta-atf3 inflammatory axis intracellular alpha-ketoglutarate maintains mutants idh1/idh2-specific inhibitors histone n-terminal tails nrf2-dependent antioxidant pathways alpha-kg-dependent histone repressing pro-inflammatory responses36 hypoxia-inducible factor-1 activation limits il-1β production95 increased 5-mc/5-hmc ratio acetyl-coa increased influx post-translational protein modifications atp-citrate lyase controls decreased anti-bactericidal activity94 s-2-hydroxyglutarate regulates cd8 ten-eleven translocation hydroxylases pro-anabolic state increasing phd activity-dependent manner iron–sulfur cluster binding85 induces hif-1α stabilization amplify ros-dependent signaling t-cell receptor triggering limited acetyl-coa conditions amp-activated protein kinase characterized fh-deficient tumors pro-inflammatory effects driven electron transport chain sdh-deficient cells displayed regulate t-cell functions89 t-cell activation recapitulating

Schema {🗺️}

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      headline:Mitochondrial TCA cycle metabolites control physiology and disease
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