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Keywords {🔍}

doi, pubmed, google, scholar, hifα, hif, pmc, article, free, hypoxia, semenza, mice, factor, cell, hypoxiainducible, cells, increased, expression, cancer, activity, zhang, genes, blood, responses, wang, pulmonary, liu, development, role, response, wound, oxygen, levels, hypoxic, vascular, ischemia, hifa, angiogenic, metastasis, hypertension, chronic, protein, conditions, gene, impaired, treatment, inhibitor, systemic, lung, limb,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated basic helix-loop-helix-pas hif-1-regulated gene dec1/stra13 high-resolution genome-wide mapping hif-1α heterozygous-null mice i5-r5-i5-r5-i30 bone marrow-derived cells ros-mediated multi-organ failure hypoxia-dependent anti-inflammatory pathways platelet-derived growth factor hif-1α-null cells die increased hif-1α-dependent expression pmc beta search decreased hif-2α-dependent expression recurrent apnea-induced morbidities hypoxia-inducible factor 1α hif-1 inhibitor digoxin excessive small-vessel proliferation hypoxia-inducible factor induction hypoxia-inducible factor 2α epithelial hypoxia-inducible factor-1 mice lacking hif-2α tca/citric acid/krebs intestinal ischemia-reperfusion injury hypoxia-inducible factor-1 activity o2-sensing glomus cells impaired small-vessel responses hypoxia-inducible factor signaling hif-1α protein levels induces hif-1-dependent transcription hif-1α gene therapy high-energy phosphate bond include hif hypo-responders cih induces hif-1α wild-type mice subjected single hif-1α homolog impaired large-vessel responses modest hif-2α gain young db/db mice db/db mice exposed include hif-1-dependent expression hypoxia-induced lysyl oxidase reactive oxygen species decreased hif-2α levels oxygen sensing system severe abdominal trauma ischaemic preconditioning-induced cardioprotection high-altitude tibetans maintain transcription start site hydroxylase inhibitor dimethyloxalylglycine

Questions {❓}

• Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?

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