
NCBI . NLM . NIH . GOV {
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Title[redir]:
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity - PMC
Description:
Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics ...
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Keywords {🔍}
trained, doi, immunity, fumarate, monocytes, figure, βglucan, cells, data, pubmed, google, scholar, metabolic, pathways, metabolism, pmc, epigenetic, shown, article, metabolites, cell, day, glycolysis, performed, free, immune, lps, analysis, production, induction, training, glutamine, histone, macrophages, glucose, cholesterol, metformin, cheng, innate, synthesis, pathway, effect, days, glutaminolysis, inhibition, βglucantrained, human, cytokine, hkme, αketoglutarate,
Topics {✒️}
table s2 nihms927418-supplement-table_s2 table s3 nihms927418-supplement-table_s3 table s1 nihms927418-supplement-table_s1 cholesterol syntheses hmg-coa-reductase high-performance liquid chromatography van den bossche β-glucan-induced trained immunity supplementary materials included pmc beta search gilson uv/vis_155 detector hmg-coa reductase inhibitor hyper-osmotic percoll solution vivo β-glucan-induced training drosophila jak/stat pathway wilcoxon signed-rank test α-kg-dependent histone embedding data-rich visualizations 1h-nmr pulse sequence water/acetonitrile/methanol/formic acid undergo β-glucan training methanol-free 1% formaldehyde β-glucan-induced training long-term functional programs β-glucan-modulated metabolism 13c-1h-hsqc spectra hif-1α-mediated aerobic glycolysis pyrogen-free pbs β-glucan-exposed cells network-level context revealed α-ketoglutarate-dependent demethylases β-glucan-trained macrophages β-glucan trained macrophages lps-induced immunotolerant macrophages license information pmcid raw lc-ms data β-glucan training mrna ethical animal committee perform pathway-enrichment analysis β-glucan versus lps murine experimental data β-glucan trained mice β-glucan-trained mice β-glucan-trained monocytes fumarate-induced trained immunity β-glucan-trained cells tsp-d4 final concentration rate-limiting enzyme cell lysis buffer adhering percoll-isolated monocytes principal component analysis
Questions {❓}
- Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T-cell function and cancer?
- Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
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Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi