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We are analyzing https://www.nature.com/articles/s41423-019-0222-4.

Title:
NK cell recognition of hematopoietic cells by SLAM-SAP families | Cellular & Molecular Immunology
Description:
The signaling lymphocyte activation molecule (SLAM) family of receptors (SFRs) are ubiquitously expressed on immune cells, and they regulate multiple immune events by recruiting SH2 (Src homology 2) domain-containing SAP family adapters, including SAP and its homologs, Ewingโ€™s sarcoma-associated transcript 2 (EAT-2) and EAT-2 related transducer (ERT). In human patients with X-linked lymphoproliferative (XLP) disease, which is caused by SAP mutations, SFRs alternatively bind other inhibitory SH2 domain-containing molecules to suppress immune cell activation and development. NK cells express multiple SFRs and all SAP family adapters. In recent decades, SFRs have been found to be critical for enhancing NK cell activation in response to abnormal hematopoietic cells in SAP-family-intact NK cells; however, SFRs might suppress NK cell activation in SAP-family-deficient mice or patients with XLP1. In this paper, we review how these two distinct SFR signaling pathways orchestrate NK cell activation and inhibition and highlight the importance of SFR regulation of NK cell biology and their physiological status and pathological relevance in patients with XLP1.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {๐Ÿ“š}

  • Science
  • Education
  • Telecommunications

Content Management System {๐Ÿ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of nature.com audience?

๐Ÿ™๏ธ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 50,449,386 visitors per month in the current month.

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How Does Nature.com Make Money? {๐Ÿ’ธ}


Display Ads {๐ŸŽฏ}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {๐Ÿ’ฐ}


Display Ads {๐ŸŽฏ}

$640,000 per month
Our analysis indicates Nature.com generates between $423,817 and $1,165,496 monthly online from display ads.

Keywords {๐Ÿ”}

pubmed, google, scholar, cas, cell, cells, immunol, central, natural, killer, sap, activation, receptor, signaling, family, receptors, nature, med, slam, xlinked, nat, human, cytotoxicity, article, immune, lymphoproliferative, exp, disease, access, immunity, hematopoietic, blood, marrow, regulation, cancer, adaptor, bone, molecular, dong, eat, inhibitory, mice, rev, content, chen, cookies, function, immunology, recognition, gene,

Topics {โœ’๏ธ}

nature portfolio permissions reprints privacy policy kill epstein-barr virus-infected epstein-barr virus-specific defects national key research author information authors advertising immunological research nature 421 nature 395 nature 349 nature sap-family-intact nk cells x-linked lymphoproliferative syndrome x-linked lymphoproliferative disease social media sap-pkc-theta interaction contributing hematopoietic stem-cell transplantation nk cell-mediated cytotoxicity slam family-mediated crosstalk platelet-nk cell aggregates nk cell-mediated rejection sh2-domain encoding gene sh2 domain-encoding gene nkt cell development pak-interacting exchange factor c-cbl ubiquitin ligase c-maf-mediated interactions slam-sap families x-linked lymphoproliferative ntb-a-mediated activation mhc-deficient haemopoietic cells sap-family-deficient mice personal data src-related kinase fyn bone marrow milieu bone marrow allografts springerlink instant access irradiated mhc-matched mice natural killer cells data protection nk cell education adaptor protein 3bp2 permissions cell receptor signaling development program human nk cells nk cell biology nk cell killing

Questions {โ“}

  • How do SAP family deficiencies compromise immunity?
  • Innate or adaptive immunity?
  • Natural killer cell activation in mice and men: different triggers for similar weapons?

Schema {๐Ÿ—บ๏ธ}

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         description:The signaling lymphocyte activation molecule (SLAM) family of receptors (SFRs) are ubiquitously expressed on immune cells, and they regulate multiple immune events by recruiting SH2 (Src homology 2) domain-containing SAP family adapters, including SAP and its homologs, Ewingรขย€ย™s sarcoma-associated transcript 2 (EAT-2) and EAT-2 related transducer (ERT). In human patients with X-linked lymphoproliferative (XLP) disease, which is caused by SAP mutations, SFRs alternatively bind other inhibitory SH2 domain-containing molecules to suppress immune cell activation and development. NK cells express multiple SFRs and all SAP family adapters. In recent decades, SFRs have been found to be critical for enhancing NK cell activation in response to abnormal hematopoietic cells in SAP-family-intact NK cells; however, SFRs might suppress NK cell activation in SAP-family-deficient mice or patients with XLP1. In this paper, we review how these two distinct SFR signaling pathways orchestrate NK cell activation and inhibition and highlight the importance of SFR regulation of NK cell biology and their physiological status and pathological relevance in patients with XLP1.
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      headline:NK cell recognition of hematopoietic cells by SLAM-SAP families
      description:The signaling lymphocyte activation molecule (SLAM) family of receptors (SFRs) are ubiquitously expressed on immune cells, and they regulate multiple immune events by recruiting SH2 (Src homology 2) domain-containing SAP family adapters, including SAP and its homologs, Ewingรขย€ย™s sarcoma-associated transcript 2 (EAT-2) and EAT-2 related transducer (ERT). In human patients with X-linked lymphoproliferative (XLP) disease, which is caused by SAP mutations, SFRs alternatively bind other inhibitory SH2 domain-containing molecules to suppress immune cell activation and development. NK cells express multiple SFRs and all SAP family adapters. In recent decades, SFRs have been found to be critical for enhancing NK cell activation in response to abnormal hematopoietic cells in SAP-family-intact NK cells; however, SFRs might suppress NK cell activation in SAP-family-deficient mice or patients with XLP1. In this paper, we review how these two distinct SFR signaling pathways orchestrate NK cell activation and inhibition and highlight the importance of SFR regulation of NK cell biology and their physiological status and pathological relevance in patients with XLP1.
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External Links {๐Ÿ”—}(261)

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