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liver, apapinduced, ferroptosis, apap, lipid, pubmed, article, hepatotoxicity, cell, mice, google, scholar, fer, peroxidation, cas, fig, death, injection, failure, gsh, acute, levels, expression, hepatic, vehicle, serum, mechanism, role, japan, mgkg, supplementary, central, data, oxidation, acid, acsl, nature, mrna, injected, samples, alt, ast, autooxidation, cype, treated, fatty, hne, mda, therapeutic, research,

Topics {✒️}

nature portfolio crispr/cas9 genome editing scientific research privacy policy n-acetyl-p-benzoquinone imine looh + 2gsh → loh + h2o + gssg real-time rt-pcr analysis development-core research advertising nature 514 nature receptor-interacting protein kinase author information authors supplementary information social media liquid chromatography/mass spectrometry supplementary excel file crispr/cas9-mediated acsl4 deletion targeting ets1/gpx4-mediated ferroptosis reprints high-dose apap-induced lethality febs open biol acetaminophen-induced liver injury ad libitum access smoking research foundation exosomal mir-499a-5p hepatic ischemia-reperfusion injioury singlet oxygen-induced oxidation30 dihomo-γ-linolenic acid n-6 fatty acids hepatic ischemia-reperfusion injury ras-mutated cancer cells pan-leukocyte marker cd45 apap-induced cell death apap-induced liver failure24 polyunsaturated fatty acid supplementary table 1 ferroptosis-resistant cell state crispr-mediated direct mutation iron-dependent cell death trigger apap-induced hepatotoxicity15 apap-induced mitochondrial dysfunction apap-induced lipid peroxidation26 cysteine-deprivation-induced ferroptosis hydrodynamics-based transfection method established life-saving procedure2 diarylamine radical-trapping antioxidants cancer-acquired drug resistance student research award supplementary fig

Questions {❓}

• Acetaminophen (APAP) hepatotoxicity-Isn’t it time for APAP to go away?
• The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
• The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity?
• Unsolved mysteries: how does lipid peroxidation cause ferroptosis?

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      url:http://orcid.org/0000-0003-3360-3185
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      name:Ryo Kamata
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      name:Ariunaa Sampilvanjil
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      name:Junya Ito
      affiliation:
            name:Tohoku University
            address:
               name:Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
               type:PostalAddress
            type:Organization
      name:Kiyotaka Nakagawa
      affiliation:
            name:Tohoku University
            address:
               name:Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
               type:PostalAddress
            type:Organization
      name:Hiroshi Kuwata
      affiliation:
            name:Showa University
            address:
               name:Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Shuntaro Hara
      affiliation:
            name:Showa University
            address:
               name:Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Koichi Mizuta
      affiliation:
            name:Saitama Children’s Medical Center
            address:
               name:Department of Transplant Surgery, Saitama Children’s Medical Center, Saitama, Japan
               type:PostalAddress
            type:Organization
      name:Yasunaru Sakuma
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      name:Naohiro Sata
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      name:Masafumi Takahashi
      url:http://orcid.org/0000-0003-2716-7532
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
      name:Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
      name:Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
      name:Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan
      name:Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, Tokyo, Japan
      name:Department of Transplant Surgery, Saitama Children’s Medical Center, Saitama, Japan
      name:Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan
      name:Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan
      name:Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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