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Title:
Coronaviruses: An Overview of Their Replication and Pathogenesis | SpringerLink
Description:
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging...
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Keywords {🔍}
pubmed, google, scholar, cas, coronavirus, central, protein, virus, virol, rna, coronaviruses, respiratory, severe, viral, replication, human, viruses, disease, acute, genome, syndrome, sarscov, nsp, proteins, hepatitis, receptor, infection, doijvi, mouse, structural, murine, identified, merscov, structure, cell, cells, sars, large, mhv, host, outbreak, assembly, cases, nonstructural, virion, membrane, domain, pathogenesis, nucleocapsid, proc,
Topics {✒️}
positive-sense full-length genomes n-acetyl-9-o-acetylneuraminic acid nsp16-2′-o-methyl transferase positive-sense rna viruses positive-sense rna genome entero-pathogenic coronavirus tgev ion channel activity interferon-induced oas-rnase negative-sense rna viruses rna-dependent rna polymerase reduced t-cell responses heavily n-linked glycosylated full-length viral genome recombinant infectious di-particles van der hoek de haan ca a-string type conformation emerging human coronavirus-emc de groot rj group 2b β-coronavirus nucleic acid-binding domain bulged stem-loop structure positive-sense counterparts murine coronavirus mhv-a59 inducing pro-inflammatory cytokines acid-dependent proteolytic cleavage severe respiratory disease viral replicase-transcriptase complex large replicase–transcriptase polyprotein pathogenic virus-specific sars coronavirus polymerase infectious bronchitis virus transmissible gastroenteritis virus n-terminal signal sequence sars-cov infection prior larger c-terminal endodomain ribose 2′-o-methylation key component cap n7 methyltransferase identified mers-cov antibodies van der zee mouse hepatitis virus porcine respiratory coronavirus highly virulent strain bat sars-related covs acute liver failure murine hepatitis virus murine hepatitis virus-4 rna stem-loop respiratory tract infections
Questions {❓}
- For instance, how does the RdRp bypass all of the TRS-B sequences to produce full-length negative-strand genomic RNA?
- Lissenberg A, Vrolijk MM, van Vliet AL et al (2005) Luxury at a cost?
Schema {🗺️}
ScholarlyArticle:
headline:Coronaviruses: An Overview of Their Replication and Pathogenesis
pageEnd:23
pageStart:1
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-2438-7.jpg
genre:
Springer Protocols
isPartOf:
name:Coronaviruses
isbn:
978-1-4939-2438-7
978-1-4939-2437-0
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Anthony R. Fehr
affiliation:
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
type:Organization
type:Person
name:Stanley Perlman
affiliation:
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Nidovirales, Coronavirus, Positive-sense RNA viruses, SARS-CoV, MERS-CoV
description:Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
datePublished:2015
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Book:
name:Coronaviruses
isbn:
978-1-4939-2438-7
978-1-4939-2437-0
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name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Anthony R. Fehr
affiliation:
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
type:Organization
name:Stanley Perlman
affiliation:
name:University of Iowa Carver College of Medicine
address:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
name:Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, USA
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