
NCBI . NLM . NIH . GOV {
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Title[redir]:
T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice - PMC
Description:
A dysregulated innate immune response and exuberant cytokine/chemokine expression are believed to be critical factors in the pathogenesis of severe acute respiratory syndrome (SARS), caused by a coronavirus (SARS-CoV). However, we recently showed ...
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Keywords {🔍}
cells, mice, cell, virus, response, balbc, fig, disease, pubmed, google, scholar, doi, infected, pmc, immune, virusspecific, infection, article, lungs, severe, respiratory, free, clearance, transferred, transfer, peptide, acute, sars, sarscov, titers, day, received, clinical, scid, innate, splenocytes, lung, dcs, spleens, ifnγ, epitopes, protection, coronavirus, activation, results, survival, pfu, syndrome, expression, immunization,
Topics {✒️}
rat anti-mouse il-17a dc/peptide s366 complexes rat anti-mouse cd8β rat anti-mouse cd16/32 anti-ifn-γ antibody rat anti-mouse interleukin-2 rat anti-mouse cd4 interferon-mediated immunopathological events rat anti-mouse il-10 coronavirus-mediated disease remains vitro-cultured virus-specific cd8 pmc beta search vitro-cultured virus-specific cd4 matrix-based screening strategy ifn-γ intracellular staining mouse-adapted sars-cov mouse-adapted sars-coronavirus sars-cov-immune b6 mice potent anti-sars-cov sars-cov s366 peptide pmc copyright notice bone marrow-derived dcs ifn-γ expression frequencies peptide s366-specific cd8 epitope s366-specific cd8 ifn-γ expression levels ifn-γ-positive cells transferred sars-cov-immune detected host-derived cd8 sars-cov cd8 peptide exuberant cytokine/chemokine expression ifn-γ protected animals sars-cov-specific cd8 transferred sars-cov-specific sars-cov-immune splenocytes sars-cov-specific cd4 peptide s366-coated bmdcs tab sars-cov-specific sars-cov-immune balb/ ma15 virus-immune splenocytes sars-cov-infected mice severe respiratory disease cells produced ifn-γ sars-cov-infected balb/ major contributory factor pathogen-free balb/ epitope n353-specific cd4 ma15 virus-infected mice cells expressed ifn-γ peptide rapidly induces
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