Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002059, but it redirected us to https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002059. The analysis below is for the second page.

Title[redir]:
No title found...
Description:
Author Summary A novel coronavirus emerged in 2003 and was identified as the etiological agent of the deadly disease called Severe Acute Respiratory Syndrome. This coronavirus replicates and transcribes its giant genome using sixteen non-structural proteins (nsp1-16). Viral RNAs are capped to ensure stability, efficient translation, and evading the innate immunity system of the host cell. The nsp16 protein is a RNA cap modifying enzyme only active in the presence of its activating partner nsp10. We have crystallized the nsp10/16 complex and report its crystal structure at atomic resolution. Nsp10 binds to nsp16 through a ∼930 Å2 activation surface area in nsp10, and the resulting complex exhibits RNA cap (nucleoside-2′-O)-methyltransferase activity. We have performed mutational and functional assays to identify key residues involved in catalysis and/or in RNA binding, and in the association of nsp10 to nsp16. We present two additional crystal structures, that of the known inhibitor Sinefungin bound in the SAM binding pocket, and that of a tighter complex made of the mutant nsp10(Y96F) bound to nsp16. Our study provides a basis for antiviral drug design as well as the first structural insight into the regulation of RNA capping enzymes in (+)RNA viruses.

Matching Content Categories {📚}

  • Books & Literature
  • Science
  • Education

Content Management System {📝}

What CMS is doi.org built with?


Doi.org operates using APACHE LENYA. But there are also traces of other content systems on the page (wordpress, 1hubspot).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

nsp, rna, view, article, structure, google, scholar, binding, cap, nspnsp, complex, residues, activity, protein, mtase, sah, fig, virus, coronavirus, interface, crystal, site, viral, omtase, sinefungin, active, sarscov, structural, plos, biol, interaction, analysis, involved, mrna, position, image, bound, surface, table, wildtype, capping, structures, sam, shown, molecule, mechanism, data, group, catalytic, domain,

Topics {✒️}

collaborative computational project global view plos pathog 7 plos pathog 6 plos pathog 1 cookies plos uk/msd-srv/prot_int/pi_link reverse genetics euro-asian sars-dtv network plos s-adenosyl-l-homocysteine derivatives uk/thornton-srv/software/ligplot/ sars-cov 2′-o-mtase nsp16 viral s-adenosylmethionine-dependent methyltransferases n-terminal hexa-histidine tag author summary open-access article distributed fr/espript/cgi-bin/espript s-adenosylmethionine-dependent methyltransferase family sam-dependent mtases share original author sars-coronavirus plnc domain bi-functional n7-guanine nsp16-mediated 2′-o-mtase s-adenosylmethionine-dependent methyltransferase fold nsp10/nsp16/sah ternary complex temperature-sensitive phenotype[22] recombinant sars-cov nsp16 sam/sah/sinfungin binding site rna-dependent rna polymerase sars-cov frankfurt-1 stranded β-sheet surrounded central n7-guanine mtase replication/transcription scaffolding protein sars-cov nsp14 methylated n7-guanine versus single-stranded negative-sense paradigmatic catechol-o-mtase[26] functional replication/transcription complex[22] conferring 2′-o-mtase activity purified sars-cov nsp10 uk/tools/msa/muscle/ single-stranded nucleic acids fo-fc difference map rna 2′-o-methylation coronavirus replicase-transcriptase proteins central β-sheet domain achieve anti-coronavirus selectivity sam-dependent mtases belong 2′-o-mtase signature sequence

Social Networks {👍}(3)

External Links {🔗}(249)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Google Universal Analytics
  • HubSpot

Libraries {📚}

  • Foundation
  • jQuery
  • Leaflet
  • Lightbox
  • Modernizr
  • Moment.js
  • Underscore.js
  • Video.js
  • Vue.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare
  • Crossref

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