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Title:
Non-coding RNAs: Classification, Biology and Functioning | SpringerLink
Description:
One of the long-standing principles of molecular biology is that DNA acts as a template for transcription of messenger RNAs, which serve as blueprints for protein translation. A rapidly growing number of exceptions to this rule have been reported over the past...
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A ceRNA hypothesis: the rosetta stone of a hidden RNA language?

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ScholarlyArticle:
      headline:Non-coding RNAs: Classification, Biology and Functioning
      pageEnd:17
      pageStart:3
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-42059-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Non-coding RNAs in Colorectal Cancer
         isbn:
            978-3-319-42059-2
            978-3-319-42057-8
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sonja Hombach
            affiliation:
                  name:University of Regensburg
                  address:
                     name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Markus Kretz
            affiliation:
                  name:University of Regensburg
                  address:
                     name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Non-coding RNA, miRNA, piRNA, snoRNA, snRNA, tRNA, rRNA, lncRNA, Classification, Biogenesis, Function
      description:One of the long-standing principles of molecular biology is that DNA acts as a template for transcription of messenger RNAs, which serve as blueprints for protein translation. A rapidly growing number of exceptions to this rule have been reported over the past decades: they include long known classes of RNAs involved in translation such as transfer RNAs and ribosomal RNAs, small nuclear RNAs involved in splicing events, and small nucleolar RNAs mainly involved in the modification of other small RNAs, such as ribosomal RNAs and transfer RNAs. More recently, several classes of short regulatory non-coding RNAs, including piwi-associated RNAs, endogenous short-interfering RNAs and microRNAs have been discovered in mammals, which act as key regulators of gene expression in many different cellular pathways and systems. Additionally, the human genome encodes several thousand long non-protein coding RNAs >200 nucleotides in length, some of which play crucial roles in a variety of biological processes such as epigenetic control of chromatin, promoter-specific gene regulation, mRNA stability, X-chromosome inactivation and imprinting. In this chapter, we will introduce several classes of short and long non-coding RNAs, describe their diverse roles in mammalian gene regulation and give examples for known modes of action.
      datePublished:2016
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Book:
      name:Non-coding RNAs in Colorectal Cancer
      isbn:
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         978-3-319-42057-8
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      name:Springer International Publishing
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      name:University of Regensburg
      address:
         name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
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      name:University of Regensburg
      address:
         name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Sonja Hombach
      affiliation:
            name:University of Regensburg
            address:
               name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Markus Kretz
      affiliation:
            name:University of Regensburg
            address:
               name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
      name:Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany
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