We are analyzing https://link.springer.com/article/10.1186/s13058-014-0453-3.

Title:
Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules | Breast Cancer Research
Description:
Introduction Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during pregnancy. However, extensive anatomical differences between mouse and human mammary tissues preclude the direct translation of rodent findings to the human breast. Therefore, here we characterize the mammary progenitor cell hierarchy and identify the anatomic location of progenitor cells within human breast tissues. Methods Mammary epithelial cells (MECs) were isolated from disease-free reduction mammoplasty tissues and assayed for stem/progenitor activity in vitro and in vivo. MECs were sorted and evaluated for growth on collagen and expression of lineages markers. Breast lobules were microdissected and individually characterized based on lineage markers and steroid receptor expression to identify the anatomic location of progenitor cells. Spanning-tree progression analysis of density-normalized events (SPADE) was used to identify the cellular hierarchy of MECs within lobules from high-dimensional cytometry data. Results Integrating multiple assays for progenitor activity, we identified the presence of luminal alveolar and basal ductal progenitors. Further, we show that Type I lobules of the human breast were the least mature, demonstrating an unrestricted pattern of expression of luminal and basal lineage markers. Consistent with this, SPADE analysis revealed that immature lobules were enriched for basal progenitor cells, while mature lobules consisted of increased hierarchal complexity of cells within the luminal lineages. Conclusions These results reveal underlying differences in the human breast epithelial hierarchy and suggest that with increasing glandular maturity, the epithelial hierarchy also becomes more complex.
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Keywords {🔍}

cells, type, lobules, breast, cell, epithelial, luminal, progenitor, basal, human, figure, mammary, pubmed, article, expression, tissue, google, scholar, enriched, lobule, populations, markers, iii, cas, colonies, cancer, types, mature, epcam, hierarchy, differences, data, spade, usa, demonstrated, growth, activity, lineages, cytometry, progenitors, gland, surface, file, results, alveolar, patient, quantified, number, studies, ductal,

Topics {✒️}

wnt/beta-catenin-responsive stem cells fluorescence-activated cell sorting related subjects human bone marrow lineage-depleted single-cell suspensions lineage-depleted breast-reduction tissue article download pdf form bi-layered ductal colony-forming ability related measure stem/progenitor activity epithelial stem/progenitor cells avidin/biotin blocking kit lineage-committed epithelial cells full access 1 dmem/hams-f12 media lineage-restricted progenitor cells fibroblast-specific protein ib10 detect stem/progenitor activity high-dimensional cytometry data nested case-control study examined stem/progenitor activity single stem cell cell stem cell α-smooth muscle actin spanning-tree progression analysis mixed-lineage colonies occurred epcamlo/neg/cd49f+ cells immunomagnetic bead-sorted populations increasing lobular complexity patient-derived epithelial cells single-cell suspensions cultured cell lines breast myoepithelial cells lineage tracing studies pan-mouse igg stem cell technologies stem cell characteristics reduction mammoplasty tissue reduction mammoplasty surgeries myoepithelial cells isolated stem/progenitor cells type i-iii lobules stem/progenitor activity formed distinct ductal stem cell biology stem cell hierarchy heterogeneous lobular structures explore basal ductal progenitors privacy choices/manage cookies

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Gusterson B: Do ‘basal-like’ breast cancers really exist?
LaMarca HL, Rosen JM: Minireview: hormones and mammary cell fate-what will I become when I grow up?

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