We are analyzing https://link.springer.com/article/10.1186/s12943-019-1102-3.

Title:
Harnessing tumor-associated macrophages as aids for cancer immunotherapy | Molecular Cancer
Description:
Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, cancer, article, tumor, google, scholar, tams, macrophages, cas, cells, cell, immune, central, antitumor, tumors, therapy, macrophage, immunotherapy, receptor, targeting, immunity, checkpoint, tme, activation, immunosuppressive, progression, strategies, blockade, therapeutic, immunol, drug, responses, including, clinical, inhibition, delivery, tumorassociated, patients, res, function, metastasis, treatment, phenotype, response, pancreatic, complement, tgfβ, growth, models, mlike,

Topics {✒️}

anti-csf-1r antibody reveals post-sepsis-induced tumor progression tnf-related apoptosis-inducing ligand peripheral cd4+cd25- naive anti-cd47 antibody-mediated phagocytosis silica-based drug nanocapsule article download pdf antibody-dependent cellular cytotoxicity/phagocytosis tumour-induced systemic environment drug-silica complex filling de deus-wagatsuma vm cxcr4-cxcl12 axis--untapped potential enhancing n-glycan branching acquired antigen-presenting capabilities transforming growth factor-β related protein b7-h4 tumortropic monocyte-mediated delivery express cd3 ζ-chain phase 1b trial b7-h4 remains unknown cd4+cd25+ regulatory mesenchymal stem/stromal cells tumor-tropic drug delivery t-cell checkpoint immunotherapy increasing n-glycan branching anti-cd47 antibody synergizes dox-laden nanocapsule leads cxcl-12/cxcr-4 axis prevented indirect anti-tumor effects tenosynovial giant-cell tumor long blood-circulation times stromal cell-derived cxcl-12 checkpoint blockade-based immunotherapy inhibitory cd47-sirpα pathway facilitate breast-tumour metastasis previous pre-clinical studies producing anti-inflammatory cytokines b7-h4-expressing cells tumor-directed immune responses checkpoint blockade-based immunotherapies main tgf-β producers l-arginine catabolic pathways cell-mediated immune response small-molecule csf1r inhibitor b7-h4 expression identifies soluble sirpα-fc construct anti-tumor functional state tams-induced immune suppression ries ch cd47-sirpα axis resulted

Questions {❓}

Does choice of approaches, direct depletion or reprogramming of TAMs, depend on tumor type?
Is complement good or bad for cancer patients?
Is the scavenger receptor MARCO a new immune checkpoint?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Harnessing tumor-associated macrophages as aids for cancer immunotherapy
         description:Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
         datePublished:2019-12-05T00:00:00Z
         dateModified:2019-12-05T00:00:00Z
         pageStart:1
         pageEnd:16
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12943-019-1102-3
         keywords:
            Tumor immunology
            Immunotherapy
            Immune checkpoint blockade
            Tumor-associated macrophage
            Combination therapy
            Cancer Research
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-1102-3/MediaObjects/12943_2019_1102_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-1102-3/MediaObjects/12943_2019_1102_Fig2_HTML.png
         isPartOf:
            name:Molecular Cancer
            issn:
               1476-4598
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xiaolei Li
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rui Liu
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiao Su
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yongsha Pan
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaofeng Han
               affiliation:
                     name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University
                     address:
                        name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Changshun Shao
               url:http://orcid.org/0000-0003-2618-9342
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yufang Shi
               affiliation:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                     address:
                        name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Harnessing tumor-associated macrophages as aids for cancer immunotherapy
      description:Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients with solid tumors, little or no progress has been seen, presumably due to lack of adequate approaches that can reprogram the local immunosuppressive tumor milieu and thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most solid tumors, could contribute to tumor progression by stimulating proliferation, angiogenesis, metastasis, and by providing a barrier against antitumor immunity. Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies. TAMs-targeted therapeutic approaches can be roughly divided into those that deplete TAMs and those that modulate TAMs activities. We here reviewed the mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity. TAMs-focused therapeutic strategies are also summarized.
      datePublished:2019-12-05T00:00:00Z
      dateModified:2019-12-05T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12943-019-1102-3
      keywords:
         Tumor immunology
         Immunotherapy
         Immune checkpoint blockade
         Tumor-associated macrophage
         Combination therapy
         Cancer Research
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-1102-3/MediaObjects/12943_2019_1102_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-019-1102-3/MediaObjects/12943_2019_1102_Fig2_HTML.png
      isPartOf:
         name:Molecular Cancer
         issn:
            1476-4598
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xiaolei Li
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rui Liu
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiao Su
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yongsha Pan
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaofeng Han
            affiliation:
                  name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University
                  address:
                     name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Changshun Shao
            url:http://orcid.org/0000-0003-2618-9342
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yufang Shi
            affiliation:
                  name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
                  address:
                     name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Molecular Cancer
      issn:
         1476-4598
      volumeNumber:18
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
      name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University
      address:
         name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
         type:PostalAddress
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
      address:
         name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xiaolei Li
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      name:Rui Liu
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      name:Xiao Su
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      name:Yongsha Pan
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      name:Xiaofeng Han
      affiliation:
            name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University
            address:
               name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Changshun Shao
      url:http://orcid.org/0000-0003-2618-9342
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yufang Shi
      affiliation:
            name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College
            address:
               name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:Center of Translational Medicine, Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China
      name:The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, China

External Links {🔗}(507)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.8s.

LINK . SPRINGER . COM {}