We are analyzing https://link.springer.com/article/10.1007/s40265-024-02061-0.

Title:
Prevention of Rheumatoid Arthritis in At-Risk Individuals: Current Status and Future Prospects | Drugs
Description:
Early intervention has been the cornerstone of improving outcomes in patients with rheumatoid arthritis. Over the past decade, the boundaries have been pushed in an attempt to achieve effective prevention strategies in those who are at high risk of developing rheumatoid arthritis. Core risk factors including the presence of serum anti-citrullinated protein antibodies, arthralgia and subclinical inflammation on imaging are highly predictive of arthritis development. The influence of air pollution, diet and the role of microbiome on disease progression are less clear. In turn, therapeutic focus has shifted to an earlier pre-arthritis phase of the disease continuum where the clinically apparent arthritis may potentially be intercepted. Seven proof-of-concept interventional trials in at-risk individuals have been conducted so far. Whether true prevention of rheumatoid arthritis is possible remains elusive. Promising signals towards permanent disease modulation and improvement in symptom burden were seen with some immunomodulatory therapies, whilst others were unsuccessful. Long-term follow-up is required to ascertain a true effect. Looking forward, a better understanding of the natural history and underlying biological mechanisms of arthritis development and more accurate, validated risk stratification is needed.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Does periodontal treatment improve rheumatoid arthritis disease activity?
How should we treat palindromic rheumatism?
Is air pollution a risk factor for rheumatoid arthritis?
Is palindromic rheumatism a pre-rheumatoid arthritis condition?
What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis?
When and how should we use imaging in individuals at risk of rheumatoid arthritis?

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