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Title[redir]:
Is air pollution a risk factor for rheumatoid arthritis? | Journal of Inflammation | Full Text
Description:
Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case–control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution’s effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis.
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air, pollution, arthritis, article, pubmed, google, scholar, rheumatoid, risk, health, pollutants, cas, exposure, disease, study, vitamin, status, central, inflammation, factor, patients, systemic, factors, serum, cells, ohd, smoking, studies, link, traffic, association, particulate, increased, tropospheric, levels, environmental, burden, years, socioeconomic, ambient, data, including, exposures, citrullinated, specific, autoimmune, diseases, autoimmunity, world, women,
Topics {✒️}
springer nature author information authors int/__data/assets/pdf_file/0005/112199/e79097 rheumatism collaborative initiative anti‑cyclic citrullinated peptide census-tract-level median income population-based case–control study conclusion traffic bmc public health nrf2-mediated counter-regulation state privacy rights abbreviations 25 author received int/iris/bitstream/10665/141496/1/9789241548885_eng derived peptides α36-50cit38 rheumatoid arthritis-related autoantibodies hla-drb1 shared epitope ifn-γ interferon gamma amplified immuno-inflammatory activation world health organization environmental risk factors pro-inflammatory cytokine production wood smoke exposure genetic background low-income americans exposed parasitic worm product lower socio-economic status rheumatoid arthritis found inhibits il-1β production hypovitaminosis d-related autoimmunity fine/ultrafine particulate matter privacy choices/manage cookies citrullinated proteins/peptides low socio-economic status acpa-negative ra cases anti-inflammatory cytokine information rights author correspondence authors scientific editing local-scale ambient no2 particulate matters/gaseous pollutants nuclear factor ƙappa reactive oxygen species ambient air quality pdf environmental factors autoimmune rheumatic diseases additional prevalence auto-immune disease
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- Is air pollution a risk factor for rheumatoid arthritis?
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description:Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case–control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution’s effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis.
datePublished:2015-07-30T00:00:00Z
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headline:Is air pollution a risk factor for rheumatoid arthritis?
description:Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case–control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution’s effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis.
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