
DOI . ORG {
}
Title[redir]:
Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature
Description:
A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future. Virtual screening in a genome-wide association study (GWAS) meta-analysis of more than 100,000 subjects of European and Asian ancestries has revealed 42 previously unknown risk loci for rheumatoid arthritis (RA). As a follow-up, the authors developed a new in silico pipeline to identify 98 biological candidate genes at all known RA risk loci. They show that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA)1. Here we performed a genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries (29,880 RA cases and 73,758 controls), by evaluating ∼10 million single-nucleotide polymorphisms. We discovered 42 novel RA risk loci at a genome-wide level of significance, bringing the total to 101 (refs 2, 3, 4). We devised an in silico pipeline using established bioinformatics methods based on functional annotation5, cis-acting expression quantitative trait loci6 and pathway analyses7,8,9—as well as novel methods based on genetic overlap with human primary immunodeficiency, haematological cancer somatic mutations and knockout mouse phenotypes—to identify 98 biological candidate genes at these 101 risk loci. We demonstrate that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. Together, this comprehensive genetic study sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis, and provides empirical evidence that the genetics of RA can provide important information for drug discovery.
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Keywords {🔍}
risk, genes, university, article, snps, nature, loci, data, research, google, scholar, department, cas, medical, medicine, arthritis, usa, rheumatoid, rheumatology, overlap, study, drug, metaanalysis, gwas, supplementary, candidate, health, supported, japan, school, genetics, genet, hospital, center, variants, biological, association, genetic, institute, extended, disease, drugs, manchester, linkage, pleiotropy, file, analysis, information, human, genomewide,
Topics {✒️}
permissions reprints nature portfolio privacy policy scientific research author information authors regional snp associations advertising east asian populations genotyping development genome-wide association studies stage trans-ethnic meta-analysis social media genome-wide association study genome-wide association loci genome-wide significance threshold hôpitaux universitaires paris-sud previous gwas meta-analysis leonid padyukov & lars klareskog jp/~yokada/datasource/software medical research council cross-ancestry genetic architecture increased c-reactive protein nature rev nature genet nature biotechnol c-reactive protein levels genome-wide level academic medical center/university meta-analysis identifies disease-modifying antirheumatic drugs springerlink instant access human phenome-interactome network trans-ethnic fine mapping translational research institute snp–biological gene–drug alexandra zhernakova & rene genome-wide snps demonstrated region-based pleiotropy nih grants r01ar063759-01a1 defined ‘allele-based pleiotropy european research council permissions université paris-sud primary data analyses kidney function-related traits nature 491 nature 423 nature 506 nature quantile–quantile plots
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mainEntity:
headline:Genetics of rheumatoid arthritis contributes to biology and drug discovery
description:A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future. Virtual screening in a genome-wide association study (GWAS) meta-analysis of more than 100,000 subjects of European and Asian ancestries has revealed 42 previously unknown risk loci for rheumatoid arthritis (RA). As a follow-up, the authors developed a new in silico pipeline to identify 98 biological candidate genes at all known RA risk loci. They show that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA)1. Here we performed a genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries (29,880 RA cases and 73,758 controls), by evaluating â¼10 million single-nucleotide polymorphisms. We discovered 42 novel RA risk loci at a genome-wide level of significance, bringing the total to 101 (refs 2, 3, 4). We devised an in silico pipeline using established bioinformatics methods based on functional annotation5, cis-acting expression quantitative trait loci6 and pathway analyses7,8,9âas well as novel methods based on genetic overlap with human primary immunodeficiency, haematological cancer somatic mutations and knockout mouse phenotypesâto identify 98 biological candidate genes at these 101 risk loci. We demonstrate that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. Together, this comprehensive genetic study sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis, and provides empirical evidence that the genetics of RA can provide important information for drug discovery.
datePublished:2013-12-25T00:00:00Z
dateModified:2013-12-25T00:00:00Z
pageStart:376
pageEnd:381
sameAs:https://doi.org/10.1038/nature12873
keywords:
Genome-wide association studies
Virtual screening
Science
Humanities and Social Sciences
multidisciplinary
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issn:
1476-4687
0028-0836
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type:PostalAddress
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address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
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name:Di Wu
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name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
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name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
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name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
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name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.
address:
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.,
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name:Gosia Trynka
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name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
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name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
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name:Brigham and Womenâs Hospital, Harvard Medical School
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name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
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address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
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type:Organization
type:Person
name:Towfique Raj
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
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name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
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name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Chikashi Terao
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Katsunori Ikari
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Yuta Kochi
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Koichiro Ohmura
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Akari Suzuki
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Shinji Yoshida
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Robert R. Graham
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
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name:Ward Ortmann
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name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
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name:Immunology Biomarkers Group, Genentech
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name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
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name:Joshua C. Denny
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name:Vanderbilt University School of Medicine
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name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
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name:Vanderbilt University School of Medicine
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name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
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name:Vanderbilt University School of Medicine
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name:New York University Hospital for Joint Diseases
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name:New York University Hospital for Joint Diseases, New York, USA
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name:Joel M. Kremer
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name:Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, USA
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name:Dimitrios A. Pappas
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name:Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, USA
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type:Organization
type:Person
name:Lei Jiang
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name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
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name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
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type:Organization
type:Person
name:Jian Yin
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
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type:Organization
type:Person
name:Lingying Ye
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
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name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
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type:Person
name:Ding-Feng Su
affiliation:
name:Second Military Medical University, Shanghai 200433, China.
address:
name:Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.,
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type:Organization
type:Person
name:Jian Yang
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name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
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name:Gang Xie
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name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
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name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
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name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
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name:Ed Keystone
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name:Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.
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name:Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.,
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type:Person
name:Harm-Jan Westra
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name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
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type:Organization
type:Person
name:Tõnu Esko
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
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name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
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name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Andres Metspalu
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name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
type:Organization
type:Person
name:Xuezhong Zhou
affiliation:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.
address:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.,
type:PostalAddress
type:Organization
type:Person
name:Namrata Gupta
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Daniel Mirel
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Eli A. Stahl
affiliation:
name:The Department of Psychiatry at Mount Sinai School of Medicine
address:
name:The Department of Psychiatry at Mount Sinai School of Medicine, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Dorothée Diogo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Jing Cui
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Katherine Liao
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Michael H. Guo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Keiko Myouzen
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Takahisa Kawaguchi
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Marieke J. H. Coenen
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Human Genetics, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Piet L. C. M. van Riel
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Rheumatology, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Mart A. F. J. van de Laar
affiliation:
name:Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.
address:
name:Department of Rheumatology and Clinical Immunology, Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Henk-Jan Guchelaar
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Tom W. J. Huizinga
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Philippe Dieudé
affiliation:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.
address:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.,
type:PostalAddress
type:Organization
name:Université Paris 7-Diderot, Paris 75013, France.
address:
name:Université Paris 7-Diderot, Paris 75013, France.,
type:PostalAddress
type:Organization
type:Person
name:Xavier Mariette
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
type:Person
name:S. Louis Bridges Jr
affiliation:
name:University of Alabama at Birmingham
address:
name:Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Alexandra Zhernakova
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Rene E. M. Toes
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Paul P. Tak
affiliation:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.
address:
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.,
type:PostalAddress
type:Organization
name:University of Cambridge, Cambridge CB2 1TN, UK.
address:
name:University of Cambridge, Cambridge CB2 1TN, UK.,
type:PostalAddress
type:Organization
type:Person
name:Corinne Miceli-Richard
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
type:Person
name:So-Young Bang
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Hye-Soon Lee
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Javier Martin
affiliation:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.
address:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Miguel A. Gonzalez-Gay
affiliation:
name:Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.
address:
name:Department of Rheumatology, Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Luis Rodriguez-Rodriguez
affiliation:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.
address:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Solbritt Rantapää-Dahlqvist
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Lisbeth Ãrlestig
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Hyon K. Choi
affiliation:
name:Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Department of Medicine, Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Section of Rheumatology, Boston University School of Medicine
address:
name:Section of Rheumatology, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine
address:
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Yoichiro Kamatani
affiliation:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.
address:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.,
type:PostalAddress
type:Organization
type:Person
name:Pilar Galan
affiliation:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.
address:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.,
type:PostalAddress
type:Organization
type:Person
name:Mark Lathrop
affiliation:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.
address:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.,
type:PostalAddress
type:Organization
type:Person
name:Steve Eyre
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:John Bowes
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Anne Barton
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Niek de Vries
affiliation:
name:Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Larry W. Moreland
affiliation:
name:University of Pittsburgh
address:
name:Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA
type:PostalAddress
type:Organization
type:Person
name:Lindsey A. Criswell
affiliation:
name:Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco
address:
name:Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Elizabeth W. Karlson
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Atsuo Taniguchi
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Ryo Yamada
affiliation:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.
address:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Michiaki Kubo
affiliation:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Jun S. Liu
affiliation:
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Sang-Cheol Bae
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Jane Worthington
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Leonid Padyukov
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Lars Klareskog
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Peter K. Gregersen
affiliation:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System
address:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System, Manhasset, USA
type:PostalAddress
type:Organization
type:Person
name:Soumya Raychaudhuri
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Barbara E. Stranger
affiliation:
name:Section of Genetic Medicine, University of Chicago
address:
name:Section of Genetic Medicine, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
name:Institute for Genomics and Systems Biology, University of Chicago
address:
name:Institute for Genomics and Systems Biology, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
type:Person
name:Philip L. De Jager
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Lude Franke
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Peter M. Visscher
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
type:Organization
type:Person
name:Matthew A. Brown
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
type:Person
name:Hisashi Yamanaka
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Tsuneyo Mimori
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Atsushi Takahashi
affiliation:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Huji Xu
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
type:Person
name:Timothy W. Behrens
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Katherine A. Siminovitch
affiliation:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
type:Organization
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
type:Organization
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
type:Organization
type:Person
name:Shigeki Momohara
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Fumihiko Matsuda
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
address:
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.,
type:PostalAddress
type:Organization
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Kazuhiko Yamamoto
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.
address:
name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Robert M. Plenge
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
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ScholarlyArticle:
headline:Genetics of rheumatoid arthritis contributes to biology and drug discovery
description:A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future. Virtual screening in a genome-wide association study (GWAS) meta-analysis of more than 100,000 subjects of European and Asian ancestries has revealed 42 previously unknown risk loci for rheumatoid arthritis (RA). As a follow-up, the authors developed a new in silico pipeline to identify 98 biological candidate genes at all known RA risk loci. They show that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA)1. Here we performed a genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries (29,880 RA cases and 73,758 controls), by evaluating â¼10 million single-nucleotide polymorphisms. We discovered 42 novel RA risk loci at a genome-wide level of significance, bringing the total to 101 (refs 2, 3, 4). We devised an in silico pipeline using established bioinformatics methods based on functional annotation5, cis-acting expression quantitative trait loci6 and pathway analyses7,8,9âas well as novel methods based on genetic overlap with human primary immunodeficiency, haematological cancer somatic mutations and knockout mouse phenotypesâto identify 98 biological candidate genes at these 101 risk loci. We demonstrate that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. Together, this comprehensive genetic study sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis, and provides empirical evidence that the genetics of RA can provide important information for drug discovery.
datePublished:2013-12-25T00:00:00Z
dateModified:2013-12-25T00:00:00Z
pageStart:376
pageEnd:381
sameAs:https://doi.org/10.1038/nature12873
keywords:
Genome-wide association studies
Virtual screening
Science
Humanities and Social Sciences
multidisciplinary
image:
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isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:506
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Yukinori Okada
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Di Wu
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
type:Organization
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.
address:
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.,
type:PostalAddress
type:Organization
type:Person
name:Gosia Trynka
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Towfique Raj
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Chikashi Terao
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Katsunori Ikari
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Yuta Kochi
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Koichiro Ohmura
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Akari Suzuki
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Shinji Yoshida
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Robert R. Graham
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Arun Manoharan
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Ward Ortmann
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Tushar Bhangale
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Joshua C. Denny
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
type:Person
name:Robert J. Carroll
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
type:Person
name:Anne E. Eyler
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
type:Person
name:Jeffrey D. Greenberg
affiliation:
name:New York University Hospital for Joint Diseases
address:
name:New York University Hospital for Joint Diseases, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Joel M. Kremer
affiliation:
name:Albany Medical Center and The Center for Rheumatology
address:
name:Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, USA
type:PostalAddress
type:Organization
type:Person
name:Dimitrios A. Pappas
affiliation:
name:New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University
address:
name:Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Lei Jiang
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
type:Person
name:Jian Yin
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
type:Person
name:Lingying Ye
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
type:Person
name:Ding-Feng Su
affiliation:
name:Second Military Medical University, Shanghai 200433, China.
address:
name:Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.,
type:PostalAddress
type:Organization
type:Person
name:Jian Yang
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
type:Organization
type:Person
name:Gang Xie
affiliation:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
type:Organization
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
type:Organization
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
type:Organization
type:Person
name:Ed Keystone
affiliation:
name:Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.
address:
name:Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.,
type:PostalAddress
type:Organization
type:Person
name:Harm-Jan Westra
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Tõnu Esko
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
type:Organization
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Andres Metspalu
affiliation:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
type:Organization
type:Person
name:Xuezhong Zhou
affiliation:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.
address:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.,
type:PostalAddress
type:Organization
type:Person
name:Namrata Gupta
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Daniel Mirel
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Eli A. Stahl
affiliation:
name:The Department of Psychiatry at Mount Sinai School of Medicine
address:
name:The Department of Psychiatry at Mount Sinai School of Medicine, New York, USA
type:PostalAddress
type:Organization
type:Person
name:Dorothée Diogo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Jing Cui
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Katherine Liao
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Michael H. Guo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Keiko Myouzen
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Takahisa Kawaguchi
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Marieke J. H. Coenen
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Human Genetics, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Piet L. C. M. van Riel
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Rheumatology, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Mart A. F. J. van de Laar
affiliation:
name:Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.
address:
name:Department of Rheumatology and Clinical Immunology, Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Henk-Jan Guchelaar
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Tom W. J. Huizinga
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Philippe Dieudé
affiliation:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.
address:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.,
type:PostalAddress
type:Organization
name:Université Paris 7-Diderot, Paris 75013, France.
address:
name:Université Paris 7-Diderot, Paris 75013, France.,
type:PostalAddress
type:Organization
type:Person
name:Xavier Mariette
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
type:Person
name:S. Louis Bridges Jr
affiliation:
name:University of Alabama at Birmingham
address:
name:Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
type:Person
name:Alexandra Zhernakova
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Rene E. M. Toes
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Paul P. Tak
affiliation:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.
address:
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.,
type:PostalAddress
type:Organization
name:University of Cambridge, Cambridge CB2 1TN, UK.
address:
name:University of Cambridge, Cambridge CB2 1TN, UK.,
type:PostalAddress
type:Organization
type:Person
name:Corinne Miceli-Richard
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
type:Person
name:So-Young Bang
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Hye-Soon Lee
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Javier Martin
affiliation:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.
address:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Miguel A. Gonzalez-Gay
affiliation:
name:Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.
address:
name:Department of Rheumatology, Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Luis Rodriguez-Rodriguez
affiliation:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.
address:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.,
type:PostalAddress
type:Organization
type:Person
name:Solbritt Rantapää-Dahlqvist
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Lisbeth Ãrlestig
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Hyon K. Choi
affiliation:
name:Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Department of Medicine, Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Section of Rheumatology, Boston University School of Medicine
address:
name:Section of Rheumatology, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine
address:
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Yoichiro Kamatani
affiliation:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.
address:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.,
type:PostalAddress
type:Organization
type:Person
name:Pilar Galan
affiliation:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.
address:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.,
type:PostalAddress
type:Organization
type:Person
name:Mark Lathrop
affiliation:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.
address:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.,
type:PostalAddress
type:Organization
type:Person
name:Steve Eyre
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:John Bowes
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Anne Barton
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Niek de Vries
affiliation:
name:Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Larry W. Moreland
affiliation:
name:University of Pittsburgh
address:
name:Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA
type:PostalAddress
type:Organization
type:Person
name:Lindsey A. Criswell
affiliation:
name:Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco
address:
name:Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Elizabeth W. Karlson
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Atsuo Taniguchi
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Ryo Yamada
affiliation:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.
address:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Michiaki Kubo
affiliation:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Jun S. Liu
affiliation:
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Sang-Cheol Bae
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
type:Person
name:Jane Worthington
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Leonid Padyukov
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Lars Klareskog
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
type:Person
name:Peter K. Gregersen
affiliation:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System
address:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System, Manhasset, USA
type:PostalAddress
type:Organization
type:Person
name:Soumya Raychaudhuri
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
type:Person
name:Barbara E. Stranger
affiliation:
name:Section of Genetic Medicine, University of Chicago
address:
name:Section of Genetic Medicine, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
name:Institute for Genomics and Systems Biology, University of Chicago
address:
name:Institute for Genomics and Systems Biology, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
type:Person
name:Philip L. De Jager
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Lude Franke
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
type:Person
name:Peter M. Visscher
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
type:Organization
type:Person
name:Matthew A. Brown
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
type:Person
name:Hisashi Yamanaka
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Tsuneyo Mimori
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Atsushi Takahashi
affiliation:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Huji Xu
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
type:Person
name:Timothy W. Behrens
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Katherine A. Siminovitch
affiliation:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
type:Organization
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
type:Organization
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
type:Organization
type:Person
name:Shigeki Momohara
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Fumihiko Matsuda
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
address:
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.,
type:PostalAddress
type:Organization
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Kazuhiko Yamamoto
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.
address:
name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.,
type:PostalAddress
type:Organization
type:Person
name:Robert M. Plenge
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
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address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
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name:Nature
issn:
1476-4687
0028-0836
volumeNumber:506
Organization:
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logo:
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name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
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type:PostalAddress
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address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
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address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
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name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
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name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
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address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.
address:
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.,
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
name:New York University Hospital for Joint Diseases
address:
name:New York University Hospital for Joint Diseases, New York, USA
type:PostalAddress
name:Albany Medical Center and The Center for Rheumatology
address:
name:Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, USA
type:PostalAddress
name:New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University
address:
name:Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, USA
type:PostalAddress
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
name:Second Military Medical University, Shanghai 200433, China.
address:
name:Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.,
type:PostalAddress
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
name:Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.
address:
name:Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.,
type:PostalAddress
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.
address:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.,
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:The Department of Psychiatry at Mount Sinai School of Medicine
address:
name:The Department of Psychiatry at Mount Sinai School of Medicine, New York, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Human Genetics, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Rheumatology, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
name:Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.
address:
name:Department of Rheumatology and Clinical Immunology, Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.,
type:PostalAddress
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.
address:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.,
type:PostalAddress
name:Université Paris 7-Diderot, Paris 75013, France.
address:
name:Université Paris 7-Diderot, Paris 75013, France.,
type:PostalAddress
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
name:University of Alabama at Birmingham
address:
name:Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.
address:
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.,
type:PostalAddress
name:University of Cambridge, Cambridge CB2 1TN, UK.
address:
name:University of Cambridge, Cambridge CB2 1TN, UK.,
type:PostalAddress
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.
address:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.,
type:PostalAddress
name:Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.
address:
name:Department of Rheumatology, Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.,
type:PostalAddress
name:Hospital Clinico San Carlos, Madrid 28040, Spain.
address:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.,
type:PostalAddress
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
name:Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Department of Medicine, Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Section of Rheumatology, Boston University School of Medicine
address:
name:Section of Rheumatology, Boston University School of Medicine, Boston, USA
type:PostalAddress
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine
address:
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
type:PostalAddress
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.
address:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.,
type:PostalAddress
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.
address:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.,
type:PostalAddress
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.
address:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.,
type:PostalAddress
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
name:University of Pittsburgh
address:
name:Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA
type:PostalAddress
name:Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco
address:
name:Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.
address:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System
address:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System, Manhasset, USA
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
name:Section of Genetic Medicine, University of Chicago
address:
name:Section of Genetic Medicine, University of Chicago, Chicago, USA
type:PostalAddress
name:Institute for Genomics and Systems Biology, University of Chicago
address:
name:Institute for Genomics and Systems Biology, University of Chicago, Chicago, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
address:
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.,
type:PostalAddress
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
name:Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.
address:
name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.,
type:PostalAddress
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Yukinori Okada
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Di Wu
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
type:Organization
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.
address:
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.,
type:PostalAddress
type:Organization
name:Gosia Trynka
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Towfique Raj
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
name:Chikashi Terao
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Katsunori Ikari
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
name:Yuta Kochi
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Koichiro Ohmura
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Akari Suzuki
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Shinji Yoshida
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
name:Robert R. Graham
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
name:Arun Manoharan
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
name:Ward Ortmann
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
name:Tushar Bhangale
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
name:Joshua C. Denny
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
name:Robert J. Carroll
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
name:Anne E. Eyler
affiliation:
name:Vanderbilt University School of Medicine
address:
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
type:PostalAddress
type:Organization
name:Jeffrey D. Greenberg
affiliation:
name:New York University Hospital for Joint Diseases
address:
name:New York University Hospital for Joint Diseases, New York, USA
type:PostalAddress
type:Organization
name:Joel M. Kremer
affiliation:
name:Albany Medical Center and The Center for Rheumatology
address:
name:Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, USA
type:PostalAddress
type:Organization
name:Dimitrios A. Pappas
affiliation:
name:New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University
address:
name:Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, USA
type:PostalAddress
type:Organization
name:Lei Jiang
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
name:Jian Yin
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
name:Lingying Ye
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
name:Ding-Feng Su
affiliation:
name:Second Military Medical University, Shanghai 200433, China.
address:
name:Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.,
type:PostalAddress
type:Organization
name:Jian Yang
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
type:Organization
name:Gang Xie
affiliation:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
type:Organization
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
type:Organization
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
type:Organization
name:Ed Keystone
affiliation:
name:Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.
address:
name:Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.,
type:PostalAddress
type:Organization
name:Harm-Jan Westra
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
name:Tõnu Esko
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
type:Organization
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
name:Andres Metspalu
affiliation:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.
address:
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
type:PostalAddress
type:Organization
name:Xuezhong Zhou
affiliation:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.
address:
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.,
type:PostalAddress
type:Organization
name:Namrata Gupta
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Daniel Mirel
affiliation:
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Eli A. Stahl
affiliation:
name:The Department of Psychiatry at Mount Sinai School of Medicine
address:
name:The Department of Psychiatry at Mount Sinai School of Medicine, New York, USA
type:PostalAddress
type:Organization
name:Dorothée Diogo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Jing Cui
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Katherine Liao
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Michael H. Guo
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Childrenâs Hospital
address:
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
name:Keiko Myouzen
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Takahisa Kawaguchi
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Marieke J. H. Coenen
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Human Genetics, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
name:Piet L. C. M. van Riel
affiliation:
name:Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.
address:
name:Department of Rheumatology, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
type:PostalAddress
type:Organization
name:Mart A. F. J. van de Laar
affiliation:
name:Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.
address:
name:Department of Rheumatology and Clinical Immunology, Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.,
type:PostalAddress
type:Organization
name:Henk-Jan Guchelaar
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
name:Tom W. J. Huizinga
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
name:Philippe Dieudé
affiliation:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.
address:
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.,
type:PostalAddress
type:Organization
name:Université Paris 7-Diderot, Paris 75013, France.
address:
name:Université Paris 7-Diderot, Paris 75013, France.,
type:PostalAddress
type:Organization
name:Xavier Mariette
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
name:S. Louis Bridges Jr
affiliation:
name:University of Alabama at Birmingham
address:
name:Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
type:PostalAddress
type:Organization
name:Alexandra Zhernakova
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
name:Rene E. M. Toes
affiliation:
name:Leiden University Medical Center, Leiden 2300 RC, the Netherlands.
address:
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
type:PostalAddress
type:Organization
name:Paul P. Tak
affiliation:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.
address:
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.,
type:PostalAddress
type:Organization
name:University of Cambridge, Cambridge CB2 1TN, UK.
address:
name:University of Cambridge, Cambridge CB2 1TN, UK.,
type:PostalAddress
type:Organization
name:Corinne Miceli-Richard
affiliation:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.
address:
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
type:PostalAddress
type:Organization
name:So-Young Bang
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
name:Hye-Soon Lee
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
name:Javier Martin
affiliation:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.
address:
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.,
type:PostalAddress
type:Organization
name:Miguel A. Gonzalez-Gay
affiliation:
name:Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.
address:
name:Department of Rheumatology, Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.,
type:PostalAddress
type:Organization
name:Luis Rodriguez-Rodriguez
affiliation:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.
address:
name:Hospital Clinico San Carlos, Madrid 28040, Spain.,
type:PostalAddress
type:Organization
name:Solbritt Rantapää-Dahlqvist
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Lisbeth Ãrlestig
affiliation:
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Umeå University, Umeå SE-901 87, Sweden.
address:
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
type:PostalAddress
type:Organization
name:Hyon K. Choi
affiliation:
name:Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Department of Medicine, Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Section of Rheumatology, Boston University School of Medicine
address:
name:Section of Rheumatology, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine
address:
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
type:PostalAddress
type:Organization
name:Yoichiro Kamatani
affiliation:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.
address:
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.,
type:PostalAddress
type:Organization
name:Pilar Galan
affiliation:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.
address:
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.,
type:PostalAddress
type:Organization
name:Mark Lathrop
affiliation:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.
address:
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.,
type:PostalAddress
type:Organization
name:Steve Eyre
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:John Bowes
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:Anne Barton
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:Niek de Vries
affiliation:
name:Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.
address:
name:Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
type:PostalAddress
type:Organization
name:Larry W. Moreland
affiliation:
name:University of Pittsburgh
address:
name:Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA
type:PostalAddress
type:Organization
name:Lindsey A. Criswell
affiliation:
name:Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco
address:
name:Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Elizabeth W. Karlson
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Atsuo Taniguchi
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
name:Ryo Yamada
affiliation:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.
address:
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Michiaki Kubo
affiliation:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Jun S. Liu
affiliation:
name:Harvard University
address:
name:Department of Statistics, Harvard University, Cambridge, USA
type:PostalAddress
type:Organization
name:Sang-Cheol Bae
affiliation:
name:Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.
address:
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
type:PostalAddress
type:Organization
name:Jane Worthington
affiliation:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.
address:
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:Leonid Padyukov
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
name:Lars Klareskog
affiliation:
name:Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.
address:
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
type:PostalAddress
type:Organization
name:Peter K. Gregersen
affiliation:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System
address:
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System, Manhasset, USA
type:PostalAddress
type:Organization
name:Soumya Raychaudhuri
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
address:
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
type:PostalAddress
type:Organization
name:Barbara E. Stranger
affiliation:
name:Section of Genetic Medicine, University of Chicago
address:
name:Section of Genetic Medicine, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
name:Institute for Genomics and Systems Biology, University of Chicago
address:
name:Institute for Genomics and Systems Biology, University of Chicago, Chicago, USA
type:PostalAddress
type:Organization
name:Philip L. De Jager
affiliation:
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
name:Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital
address:
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
type:PostalAddress
type:Organization
name:Lude Franke
affiliation:
name:University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.
address:
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
type:PostalAddress
type:Organization
name:Peter M. Visscher
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Queensland Brain Institute, The University of Queensland
address:
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
type:PostalAddress
type:Organization
name:Matthew A. Brown
affiliation:
name:University of Queensland Diamantina Institute, Translational Research Institute
address:
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
type:PostalAddress
type:Organization
name:Hisashi Yamanaka
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
name:Tsuneyo Mimori
affiliation:
name:Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
address:
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Atsushi Takahashi
affiliation:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Huji Xu
affiliation:
name:Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
address:
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
type:PostalAddress
type:Organization
name:Timothy W. Behrens
affiliation:
name:Immunology Biomarkers Group, Genentech
address:
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
type:PostalAddress
type:Organization
name:Katherine A. Siminovitch
affiliation:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
address:
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
type:PostalAddress
type:Organization
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.
address:
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
type:PostalAddress
type:Organization
name:University of Toronto, Toronto, Ontario M5S 2J7, Canada.
address:
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
type:PostalAddress
type:Organization
name:Shigeki Momohara
affiliation:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.
address:
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
type:PostalAddress
type:Organization
name:Fumihiko Matsuda
affiliation:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
address:
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.,
type:PostalAddress
type:Organization
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
address:
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
type:PostalAddress
type:Organization
name:Kazuhiko Yamamoto
affiliation:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
address:
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
type:PostalAddress
type:Organization
name:Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.
address:
name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.,
type:PostalAddress
type:Organization
name:Robert M. Plenge
affiliation:
name:Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Brigham and Womenâs Hospital, Harvard Medical School
address:
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Program in Medical and Population Genetics, Broad Institute
address:
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Department of Statistics, Harvard University, Cambridge, USA
name:Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3800, Australia.,
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
name:Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, USA
name:Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
name:New York University Hospital for Joint Diseases, New York, USA
name:Department of Medicine, Albany Medical Center and The Center for Rheumatology, Albany, USA
name:Division of Rheumatology, Department of Medicine, New York, Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, USA
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
name:Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.,
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
name:Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto M5S 2J7, Canada.,
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
name:Estonian Genome Center, University of Tartu, Riia 23b, Tartu 51010, Estonia.,
name:School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China.,
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:The Department of Psychiatry at Mount Sinai School of Medicine, New York, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Division of Endocrinology, Childrenâs Hospital, Boston, USA
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
name:Department of Human Genetics, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
name:Department of Rheumatology, Radboud University Medical Centre, Nijmegen 6500 HB, the Netherlands.,
name:Department of Rheumatology and Clinical Immunology, Arthritis Center Twente, University Twente & Medisch Spectrum Twente, Enschede 7500 AE, the Netherlands.,
name:Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
name:Service de Rhumatologie et INSERM U699 Hôpital Bichat Claude Bernard, Assistance Publique des Hôpitaux de Paris, Paris 75018, France.,
name:Université Paris 7-Diderot, Paris 75013, France.,
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
name:Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
name:Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.,
name:AMC/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
name:GlaxoSmithKline, Stevenage SG1 2NY, UK.,
name:University of Cambridge, Cambridge CB2 1TN, UK.,
name:Institut National de la Santé et de la Recherche Médicale (INSERM) U1012, Université Paris-Sud, Rhumatologie, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicêtre 94275, France.,
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
name:Instituto de Parasitologia y Biomedicina Lopez-Neyra, CSIC, Granada 18100, Spain.,
name:Department of Rheumatology, Hospital Marques de Valdecilla, IFIMAV, Santander 39008, Spain.,
name:Hospital Clinico San Carlos, Madrid 28040, Spain.,
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
name:Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.,
name:Department of Rheumatology, Umeå University, Umeå SE-901 87, Sweden.,
name:Department of Medicine, Channing Laboratory, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Section of Rheumatology, Boston University School of Medicine, Boston, USA
name:Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, USA
name:Centre dâEtude du Polymorphisme Humain (CEPH), Paris 75010, France.,
name:Université Paris 13 Sorbonne Paris Cité, UREN (Nutritional Epidemiology Research Unit), Inserm (U557), Inra (U1125), Cnam, Bobigny 93017, France.,
name:McGill University and Génome Québec Innovation Centre, Montréal, Québec H3A 0G1 Canada.,
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
name:Department of Clinical Immunology and Rheumatology & Department of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam 1105 AZ, the Netherlands.,
name:Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, USA
name:Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
name:Unit of Statistical Genetics, Center for Genomic Medicine Graduate School of Medicine Kyoto University, Kyoto 606-8507, Japan.,
name:Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Department of Statistics, Harvard University, Cambridge, USA
name:Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, South Korea.,
name:Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK.,
name:National Institute for Health Research, Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
name:Department of Medicine (Solna), Rheumatology Unit, Karolinska Institutet, Stockholm SE-171 76, Sweden.,
name:The Feinstein Institute for Medical Research, North ShoreâLong Island Jewish Health System, Manhasset, USA
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.,
name:Section of Genetic Medicine, University of Chicago, Chicago, USA
name:Institute for Genomics and Systems Biology, University of Chicago, Chicago, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
name:Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Womenâs Hospital, Boston, USA
name:Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9700 RB, the Netherlands.,
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
name:Queensland Brain Institute, The University of Queensland, Brisbane, Australia
name:University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
name:Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.,
name:Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.,
name:Immunology Biomarkers Group, Genentech, South San Francisco, USA
name:Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.,
name:Toronto General Research Institute, Toronto, Ontario M5G 2M9, Canada.,
name:Department of Medicine, University of Toronto, Toronto, Ontario M5S 2J7, Canada.,
name:Institute of Rheumatology, Tokyo Womenâs Medical University, Tokyo 162-0054, Japan.,
name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
name:Core Research for Evolutional Science and Technology (CREST) program, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.,
name:Institut National de la Sante et de la Recherche Medicale (INSERM) Unite U852, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.,
name:Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.,
name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-0033, Japan.,
name:Division of Rheumatology, Immunology, and Allergy, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Division of Genetics, Brigham and Womenâs Hospital, Harvard Medical School, Boston, USA
name:Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
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- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andres%20Metspalu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
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- Revenue of https://www.nature.com/articles/nature12873/search?author=Katherine%20Liao
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- Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Katherine%20Liao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
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- What is the earnings of https://www.nature.com/articles/nature12873/search?author=Takahisa%20Kawaguchi?
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- See how much https://www.nature.com/articles/nature12873/search?author=Mart%20A.%20F.%20J.%20van%20de%20Laar makes per month
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- https://www.nature.com/articles/nature12873/search?author=Paul%20P.%20Tak's total income per month
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- What's the monthly income of https://www.nature.com/articles/nature12873/search?author=Sang-Cheol%20Bae?
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- https://www.nature.com/articles/nature12873/search?author=Jane%20Worthington's financial summary
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- Revenue of https://www.nature.com/articles/nature12873/search?author=Lars%20Klareskog
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- What are the earnings of https://www.nature.com/articles/nature12873/search?author=Philip%20L.%20De%20Jager?
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- How much cash flow does https://www.nature.com/articles/nature12873/search?author=Lude%20Franke have monthly?
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- How much does https://www.nature.com/articles/nature12873/search?author=Tsuneyo%20Mimori earn?
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- https://www.nature.com/articles/nature12873/search?author=Atsushi%20Takahashi's revenue stream
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