We are analyzing https://link.springer.com/article/10.1007/s40264-018-0779-3.

Title:
Safety and Tolerability of Adoptive Cell Therapy in Cancer | Drug Safety
Description:
Adoptive T cell therapy (ACT) is a safe and effective personalized cancer immunotherapy that can comprise naturally occurring ex vivo expanded cells (e.g., tumor-infiltrating lymphocytes [TIL]) or T cells genetically engineered to confer antigen specificity (T-cell receptor [TCR] or chimeric antigen receptor [CAR] engineered T cells) to mediate cancer rejection. In recent years, some ACTs have produced unprecedented breakthrough responses: TIL therapy has moved from melanoma to solid tumor applications, TCR-engineered cells are developed for hematologic and solid tumors, and CAR-engineered T cells have received Food and Drug Administration (FDA) approval for the treatment of patients with certain B-cell malignancies. Although results are encouraging, to date, only a small percentage of patients with advanced malignancies can benefit from ACT. Besides ACT availability and accessibility, treatment-related toxicities represent a major hurdle in the widespread implementation of this therapeutic modality. The large variety of observed toxicities is caused by the infused cell product or as side effects of accompanying medication and chemotherapy. Toxicities can occur immediately or can be delayed. In order to render those highly promising therapeutic approaches safe enough for a wider pool of patients outside of clinical trials, an international consensus for toxicity management needs to be established.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cancer, cell, cells, therapy, patients, lymphocytes, adoptive, clin, tcell, melanoma, receptor, antigen, med, metastatic, transfer, res, oncol, tumor, chimeric, nat, dudley, gene, immunotherapy, human, sci, yang, tumorinfiltrating, interleukin, toxicity, safety, management, rosenberg, van, httpsdoiorgccr, immunol, httpsdoiorgs, blood, httpsdoiorgblood, engineered, treatment, receptors, httpsdoiorgjco, arber, car,

Topics {✒️}

anti-cd19 chimeric-antigen-receptor-transduced titin-derived hla-a1-presented peptide lethal graft-versus-host disease ebv-specific t-cell infusions t-cell-receptor gene therapy month download article/chapter human papillomavirus-targeted tumor-infiltrating chimeric antigen receptor-modified suicide-gene-engineered donor lymphocytes ny-eso-1-specific tcr-engineered allogeneic graft-versus-leukemia t-cell receptor [tcr] transduced tumor-specific tcrs tumor-infiltrating lymphocyte cultures safer t-cell therapy engineered mage a3-directed lionel trueb & george coukos autologous tumor antigen-specific antigen-negative humanized mice human t-cell receptors dr benita wolf transposon-based gene therapy cell receptor complex engineered t-cell therapies prolonged disease-free period car t-cell therapy tumor-infiltrating lymphocytes [til] autologous tumor-infiltrating lymphocytes indolent b-cell malignancies anti-lymphoma/leukemia effects chimeric antigen receptor cd19-targeted therapy ctl019 adoptive t-cell transfer dr melita irving t-cell transfer immunotherapy hsv-tk gene transfer author correspondence lentivirus-mediated gene transfer low-dose recombinant interleukin-2 full article pdf cognate peptide presented cell-mediated tumor immunotherapy article wolf t-cell therapy dual hla class chimeric antigen receptors t-cell receptors dr lionel trueb blood-brain barrier disruption tumor-infiltrating lymphocytes

Questions {❓}

Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?
T-cell receptor gene therapy—ready to go viral?
TCR-engineered T cells to treat tumors: seeing but not touching?

Schema {🗺️}

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