
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients - PMC
Description:
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to conventional therapies. We report here on the results of an ongoing Phase II clinical trial testing ...
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Keywords {🔍}
til, cells, patients, doi, clinical, response, therapy, tumor, melanoma, google, scholar, pubmed, infused, cell, responders, fig, patient, telomere, found, pmc, nonresponders, infusion, btla, cancer, article, irrc, percentage, analysis, free, metastatic, number, treated, antitumor, tcell, length, data, regression, responses, expansion, expanded, months, total, transfer, study, online, adoptive, survival, significant, disease, burden,
Topics {✒️}
wilcoxon rank-sum tests pre-rep anti-tumor reactivity activation-induced cell death autologous tumor-infiltrating lymphocytes tumor-infiltrating lymphocyte cultures mediating anti-tumor responses positive ifn-γ secretion ��100 pg/ml ifn-γ human tumor-specific cd8+ progression-free survival times cd45ra−cd62l−cd27+cd28+ cd45ra−cd62l−cd27−cd28− mitogen-activated protein kinase positive anti-tumor reactivity multi-color flow cytometry cd8+ t-cell lineage major t-cell subsets pmc beta search tumor-infiltrating lymphocyte expansion adoptive t-cell therapy adoptively transferred tumor-reactive til anti-tumor reactivity memory t-cell differentiation tumor antigen-specific cd8 tumor antigen-specific cd8+ long-term survival update active t-cell populations improved anti-tumor activity cd8+ t-cell differentiation cell-mediated cancer immunotherapy cd8+cd45ra−cd62l−cd27+ cd8+cd45ra−cd62l−cd27− cd8+cd45ra−cd62l+cd27+ t-cell transfer immunotherapy tumor-infiltrating lymphocytes unconventional ligand activation human effector-memory cd8+ human cd8+cd27− teff immune-related response criteria cd45ra−cd62l−cd27−btla+ anti-tumor reactivity cell clones specific dominant vβ clonotypes �negative” costimulatory molecules anti-tumor activity dominant vβ clonotype cryopreserved pre-rep til anti-cd3 activation anti-human tim3 anti-human lag-3
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