
NCBI . NLM . NIH . GOV {
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Title[redir]:
An inducible caspase 9 safety switch for T-cell therapy - PMC
Description:
The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have ...
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Keywords {🔍}
cells, caspase, cid, expression, doi, human, pubmed, google, scholar, apoptosis, icaspm, figure, gene, transduced, gfp, ctls, molecules, activation, transgene, high, inducible, tcell, function, suicide, shown, death, mice, administration, cell, pmc, article, vivo, transduction, levels, data, fkbp, dimerization, lymphocytes, results, nontransduced, ebvctls, blood, safety, antiapoptotic, activity, treatment, virus, constructs, protein, elimination,
Topics {✒️}
ser-gly-gly-gly-ser linker full-length construct f'f-c-casp9 nonfunctional icasp9c→s-transduced ebv-ctls f'f-c-casp9c→s-transduced nonfunctional construct f'f-c-casp9c→ epstein-barr virus-positive hodgkin' t-cell-receptor gene therapy epstein-barr virus-induced lymphoma apoptosis-resistant t-cell line transformed t-cell lines transformed t-cell line antigen-specific t-cell receptors hsv-tk–directed immune responses b-cell cll/lymphoma-2 fas-resistant htlv-i-infected t-cell therapy karin artificial t-cell receptors gene-modified hiv-specific cytotoxic t-cell mediated rejection human t-cell therapies t-cell–based therapies tumor necrosis factor-α graft-versus-host disease f'f-c-casp9c→ human epstein-barr virus allogeneic graft-versus-leukemia pmc beta search adoptive t-cell therapy donor t-cell infusions peroxidase-coupled secondary antibodies plasmids encoding gag-pol pancaspase inhibitor zvad-fmk ebv-specific ctl lines alter t-cell characteristics bacteria-derived lethal genes f'f-c-casp9 f'-f-c-casp9 death-inducing signaling complex th2-type cytokines unlike virus-derived proteins enzyme-linked immunosorbent assay b-17 scid/scid mice detectable il-12–producing cells t-cell therapy constructs f'f-casp9 f'f-casp9 constructs conformational change–induced activation require long-term persistence activation-induced cell death conserved xiap-interaction motif
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