
NCBI . NLM . NIH . GOV {
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Title[redir]:
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma - PMC
Description:
Engineered T-cell receptors can have redundant recognition of alternative protein motifs, resulting in severe cardiac toxicity. The use of induced pleuripotent stem cells (iPSCs) is a promising approach to identify potential off-target effects of ...
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Keywords {🔍}
cells, doi, pgml, cell, blood, engineered, tcell, google, scholar, tcr, pubmed, case, cardiac, patients, magea, pmc, article, figure, toxicity, titin, analysis, normal, free, tcrs, clinical, antigen, cancer, days, heart, samples, patient, standard, dna, infusion, expression, hlaa, performed, melanoma, expressed, treated, autopsy, total, infused, factor, therapy, disease, protein, tissues, derived, product,
Topics {✒️}
gov/oba/rac/meetings/june2012/rac_minutes_06-12 mage-a3–specific α/β heterodimer imaging ny-eso-1/lage-1-derived epitopes lethal graft-versus-host disease t-cell-receptor gene therapy enhanced t-cell–mediated myocarditis anti-mage t-cells induced patchy full-thickness hemorrhages parental mage-a3–specific tcr graft-versus-host disease graft-versus-host disease chimeric antigen receptor–modified chimeric antigen receptor-modified mage-a3–specific dextramer reagent affinity-enhanced mage-a3a3a tcr mispaired mage-a3–engineered tcr forward scatter/side scatter intra-aortic balloon pump suggested pre-tamponade physiology human t-cell receptors hla-a1+ cell lines cross-reactive epitope derived express t-cell receptors dysregulated t-cell activation transduced t-cell product received adjuvant ifn-α specific tcr-β chain hla-a1+ mage-a3+ normal t-cell expressed t-cell product infused mage-a3a3a tcr resulted anti-c8α-pe-cy7 anti-cd3 fluorescein isothiocyanate coronary artery disease pmc beta search 01–restricted mage-a3 peptide blood web site monocyte-depleted leukopheresis product primer/probe combination specific x-axis shows staining fresh mage-a3a3a–transduced newly mage-a3a3a–transduced mage cancer-testis family engineered t-cell biodistribution tumors expressed mage-a3 stage iii/iv melanoma moderately high-affinity tcr wt mage-a3 tcr mage-a3 tcr-engineered t-cell receptors
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